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All Journal IDJP (Indonesian Journal of Pharmaceutics) Majalah Farmasetika
Aliza Putriana, Norisca
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Medicine & Pharmacology

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Formulasi Dan Evaluasi Sediaan Toner Dari Ekstrak Biji Hanjeli (Coix Lacryma-Jobi L.) Sebagai Antioksidan Azizah, Nurul; Aliza Putriana, Norisca; Daru Asmara Tugon, Titian
Majalah Farmasetika Vol 9, No 6 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i6.59038

Abstract

Biji hanjeli (Coix lacryma-jobi L.) merupakan salah satu tanaman yang memilikikandungan aktivitas antioksidan alami yang kuat. Namun, aktivitas antioksidan inikurang dimanfaatkan terutama dalam produk kosmetik. Sediaan yang dibuat dalampenelitian ini adalah sediaan toner. Penelitian ini bertujuan untuk memformulasikantoner menggunakan ekstrak biji hanjeli yang stabil serta memiliki aktivitas antioksidanyang efektif dan dapat diaplikasikan dalam perawatan kulit wajah. Metode yangdigunakan yaitu penelitian laboratorium eksperimental dengan variasi konsentrasiekstrak pada FI (0,5%) FII (1%) dan FIII (1,5%) dengan uji stabilitas menggunakanmetode freeze thaw sebanyak 3 siklus serta mengamati perubahan nilai pH, viskositasdan homogenitas pada produk, evaluasi yang dilakukan pada setiap formula bertujuanuntuk menentukan karakteristik yang paling stabil dan memenuhi standar kosmetik.Selanjutnya dilakukan pengujian aktivitas antioksidan menggunakan metode DPPH(1,1-difenil-2-pikrilhidrazil) yang dianalisis menggunakan spektrofotometri UV-Vis padapanjang gelombang 517 nm. Hasil penelitian menunjukkan FII (1% ekstrak) memilikikarakteristik yang stabil dengan. pH yang tetap dalam rentang 5,0–5,5 dan viskositasoptimal. Aktivitas antioksidan tertinggi diperoleh pada ekstrak murni dengan nilai IC50sebesar 74,36 ppm, yang termasuk dalam kategori antioksidan kuat. Sedangkanformula FII menunjukkan nilai IC50 sebesar 195,69 ppm, yang termasuk dalam kategoriantioksidan lemah. Kesimpulannya, formula FII dipilih karena stabilitas fisik dan aktivitasantioksidan yang cukup baik dalam produk kosmetik, meskipun aktivitas antioksidanyalebih rendah dibandingkan ekstrak murni. Penelitian ini menunjukkan potensi ekstrak bijihanjeli sebagai bahan aktif alami dalam produk perawatan kulit yang efektif dan amandalam melindungi kulit dari efek yang merusak oleh radikal bebas dan dapatmemperlambat proses penuaan kulit.
Review: Management Technology Transfer in the Indonesian Pharmaceutical Industry Sumayyah, Shofiah; Resca Harda, Adila; Aliza Putriana, Norisca
Indonesian Journal of Pharmaceutics Vol 5, Issue 1, Jan - April 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i1.40898

Abstract

Thisreviewarticlefocusesontechnologytransferinthepharmaceuticalindustry,specifically discussingits importance,guidelines, process, and documentation intheIndonesiancontext.Thepurposeis toprovideadetailedunderstandingoftechnologytransfer from drug discovery to product development, including the reasons for its utilizationanditssignificanceinthepharmaceuticalsector.Themethodologyemployedforthisreview involvedsearching onlineliterature throughplatformssuchasScienceDirectandGoogleScholarusingkeywordslike"TransferTechnology"and "Pharmaceutical Development." Thefindings of the primary sources emphasizethecrucialroleoftechnologytransferinfacilitatingthegrowth ofthepharmaceuticalindustry. Itenables theavailabilityof essential technologiesin developing countries,promotingaccessibilityandaffordability.Threekeyfactorscontributetoeffectivetechnologytransfer:properplanning,involvementofcapableindividuals,andawell-definedprocess.Successintechnologytransfernecessitatesacomprehensiveunderstandingoftheprocessandtheabilitytopredictitsfutureperformanceaccurately.Furthermore,thearticleemphasizestheimportanceofensuringrobustandeffectivemanufacturingprocessesfordrugsubstancesanddrugproducts.Thisincludesproducingthesesubstancesandproductsincompliancewithregisteredspecifications and adhering to Good Manufacturing Practices Keywords: Transfer technology, Pharmaceutical development, Research and development, Pharmaceutical industry.
Utilization of 1-(3-aminopropyl)-imidazole in development of pH-sensitive nanocarrier for anticancer drug delivery Husni, Patihul Husni; Aliza Putriana, Norisca
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.40691

Abstract

pH-sensitive nanocarriers have demonstrated as successful drug carriers due to the higher drug accumulation at the tumor site by pH dependent release at acidic tumor microenvironment. Imidazole can be utilized to obtain the pH-sensitive nanocarriers. One of imidazole-based compounds used by researchers in development of pH-responsive carriers is 1-(3-Aminopropyl)-imidazole. This review is focused on utilization of 1-(3-aminopropyl)-imidazole to develop pH-sensitive nanocarrier especially for delivery of anticancer drug. In addition, this review also shows research performed by researchers to develop pH-sensitive nanocarrier for anticancer drug delivery using 1-(3-aminopropyl)-imidazole to prepare imidazole-based pH-sensitive nanocarriers. The data were collected from published journals with 15 and 20 journals as primary and supporting literatures, respectively. Properties of imidazole groups to deprotonate at pH 7.4 and protonate at pH ≤ 6.5 implies that the drug release was pH-dependent, leading to limited release of drug from carriers under physiological pH conditions and diminishing the drug’s effect in blood circulation before reaching the tumor site, resulting in more effective anticancer activity.
Co-Authors Daru Asmara Tugon, Titian Husni, Patihul Husni NURUL AZIZAH Resca Harda, Adila Sumayyah, Shofiah