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Nova Mahendra, Agung
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Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Law, Crime, Criminology & Criminal Justice Public Health Social Sciences

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Effects of yoga exercise in reducing the risk of knee osteoarthritis and fibulin-3 levels among overweight population: a randomized controlled trial Wahyuni, Nila; Adiatmika, I Putu Gede; Vittala, Govinda; Nova Mahendra, Agung
Public Health and Preventive Medicine Archive Vol. 11 No. 2 (2023)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2023.v11.i2.p04

Abstract

Background and purpose: One of the main risk factors for knee osteoarthritis is overweight. The purpose of this study is to determine the effectiveness of yoga exercise in reducing the risk of knee osteoarthritis and fibulin-3 levels in overweight populations. Methods: This study was a randomized controlled trial involving 24 participants who met the inclusion and exclusion criteria. Participants were randomly divided into two groups: group one was given yoga exercise intervention and group two was given neuromuscular coordination exercise as the control group. Risk of knee osteoarthritis measurements were carried out using The Western Ontario and McMasters University Osteoarthritis Index (WOMAC). Fibulin-3 measurement used ELISA technique using human fibulin-3 kit, FBLN3 BT-LABkit 96T E4667Hu. Results: Participants of both groups were comparable, except for age where the control group is slightly older. Pre and post-test comparison showed improvement in pain, stiffness, physical function, total WOMAC score, and fibulin-3 levels in both groups. While, the post-test comparison between the two groups showed that yoga group has better scores on all indicators compared to the control groups which was statistically significant (p≤0.001). Conclusion: Both interventions are effective in reducing the risk of knee osteoarthritis and fibulin-3 levels, but yoga showed better result. We recommend yoga training to reduce the risk of knee osteoarthritis compared to conventional training. Future research is needed to measure other knee osteoarthritis biomarkers that describe the pathological process of knee osteoarthritis.
Comparative Phytochemical Profile and Antioxidant Activity of Cocoa Beans Methanol Extract and its N-Butanol Fraction Obtained from Jembrana, Bali, Indonesia Ari Chandra Wibawa, Agung; Nova Mahendra, Agung; Bagus Putra Manuaba, Ida; Nyoman Mantik Astawa, I
Journal of World Science Vol. 3 No. 4 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i4.588

Abstract

This study aims to evaluate the differences in phytochemical profiles and antioxidant activity between the methanol extract of cocoa beans and the n-butanol fraction obtained from Jembrana, Bali. Maceration technique was used in this research. The crude extract of cocoa beans was partitioned based on polarity to determine which fraction has the most potential as a source of bioactive compounds. The n-butanol fraction was evaporated to obtain a polar fraction from the methanol extract of cocoa beans. UV-Vis spectrophotometry was used to measure the total content of flavonoids and tannins in the methanol extract of cocoa beans and the n-butanol fraction. Research found that the methanol extract of Balinese cocoa beans had a total flavonoid content of 0.34 g/100 g and tannins of 0.37 g/100 g. However, the n-butanol fraction had a total flavonoid content of 15.34 g/100 g and tannin 20.16 g/100 g. The IC50 value of the methanol extract was 29.66 ?g/ml, while the n-butanol fraction was 2.63 ?g/ml. The AAI of the methanol extract was 1.35 and the n-butanol fraction was 2.63, indicating that the n-butanol fraction had stronger antioxidant activity with higher flavonoid and tannin content than the methanol extract. The implication of this research is that the n-butanol fraction of cocoa bean methanol extract has the potential as a source of bioactive compounds that can be utilized in the development of high added value products, especially in the context of food pharmaceuticals or other health product.
Co-Authors Agung Ari Chandra Wibawa Bagus Putra Manuaba, Ida I Putu Gede Adiatmika Nila Wahyuni Nyoman Mantik Astawa, I Vittala, Govinda