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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Jurnal Sains dan Teknologi Indonesian Journal of Pharmaceutical Science and Technology Akta Kimia Indonesia Widyadari : Jurnal Pendidikan Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian UNDIKMA Hydrogen: Jurnal Kependidikan Kimia Jurnal Pengabdian Kepada Masyarakat Widya Mahadi

Agung Ari Chandra Wibawa

Program Studi Sarjana Farmasi Fakultas Farmasi Universitas Mahasaraswati Denpasar

Author-ID : 231655

Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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PEMBUATAN HAIR TONIC BERBAHAN DASAR LIDAH BUAYA DAN ANALISIS DENGAN FOURIER TRANSFORM INFRARED Sanjiwani, Ni Made Sukma; Paramitha, Dewa Ayu Ika; Wibawa, Agung Ari Chandra; Ariawan, I Made Dedy; Megawati, Fitria; Dewi, Ni Wayan Trisna; Mariati, Ni Putu Ayu Mirah; Sudiarsa, I Wayan
Widyadari: Jurnal Pendidikan Vol. 21 No. 1 (2020): April 2020
Publisher : LPPM IKIP PGRI Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar

Dewasa ini penggunaan lidah buaya sangat banyak digunakan dalam pembuatan produk kosmetik yang ramah lingkungan salah satu penggunaan lidah buaya pada pembuatan hair tonic yang berguna untuk melebatkan rambut. Lidah buaya memiliki kandungan utama seperti: minyak atsiri, gum, aloin, mineral, emodin dan vitamin. Lidah buaya yang dimanfaatkan pada penelitian ini adalah gel lidah buaya dari jenis lidah buaya barbadensis yang berarti tanaman yang kaya akan protein, vitamin A, C, dan E, kalsium, untuk melembabkan kulit, menghilangkan jerawat dan meremajakan kulit. Lidah buaya juga berfungsi sebagai antibakteri dan antiinflamasi. Kandungan kimia lidah buaya yang berupa gel dapat dipaparkan secara rinci yaitu saponin, asam sinamat, lignin, polisakarida, eteral oil, acemannan, vitamin B1, B2, B6, asam folat, tannin, enzim oksidase, amilase, monosakarida, glukomanan, enzim bradikinase, dan salisilat. Berdasarkan uraian diatas, maka dilakukan penelitian yang bertujuan untuk membuat hair tonic dari lidah buaya dengan kode F1, F2 dan F3 dengan masing ? masing perbandingan ekstrak lidah buaya dan cairan lidah buaya 1:1; 1:2; 1:3, untuk mengetahui sifat fisik dari ketiga hair tonic dan untuk melihat gugus fungsi yang terdapat dalam hair tonic dengan alat instrumentasi Fourier Transform Infrared (FTIR). Hasil penelitian yang diperoleh memperlihatkan bahwa Hair tonic F1 memiliki aroma khas lavender, warna peach, bentuk cairan kental, tekstur lembut, pH 3,8 dan viskositas sebesar 0,0039 ± 0,0003 NS/m2. Gugus fungsi yang terdapat dalam hair tonic F1 yaitu -(CH2)n, C=C aromatic, C=O amida, C=O ester, C-H alkana, C-H alkuna, C-H bending, alkuna dan O-H stretching. Hair tonic F2 memiliki aroma khas melati, warna peach, bentuk caiarn kental, tekstur lembut, pH 3,7 dan viskositas sebesar 0,0034 ± 0,0002 NS/m2. Gugus fungsi yang terdapat dalam hair tonic F2 yaitu -(CH2)n, C=C aromatic, C-O-C eter, C=O aldehid, C-H alkana dan O-H stretching. Hair tonic F3 memiliki aroma khas melati-peppermint, warna peach, bentuk caiarn kental, tekstur lebih lembut, pH 3,8 dan viskositas sebesar 0,0037 ± 0,0001 NS/m2. Gugus fungsi yang terdapat dalam hair tonic F2 yaitu -(CH2)n, C=C aromatic, C-O-C eter, C=O amida, C=O aldehid, C-H alkana dan O-H stretching.

POTENSI FLAVONOID EKSTRAK BIJI MAHONI (Swietenia mahagoni Jacq) UNTUK MENURUNKAN KONSENTRASI 8-OHdG PADA URIN TIKUS WISTAR JANTAN YANG TERPAPAR ETANOL Agung Ari Chandra Wibawa; I Made Dira Swantara; Manuntun Manurung
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 4 No 2 (2016)
Publisher : Magister Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.87 KB)

ABSTRAK : Penelitian ini bertujuan untuk menentukan fraksi aktif senyawa flavonoid biji mahoni sebagai antioksidan untuk menurunkan konsentrasi 8-OHdG dalam urin tikus yang terpapar etanol. Uji kadar total flavonoid pada fraksi dilakukan dengan metode spektrofotometri UV-Vis yang menunjukan fraksi n-butanol mengandung flavonoid terbanyak yaitu sebesar 41,734 mg/L. Pengukuran konsentrasi 8-OHdG dilakukan dengan ELISA pada panjang gelombang 450 nm. Hasil analisis dengan ELISA, dosis 50, 100, 150, dan 200 mg/kg selama 21 hari bb terbukti dapat menurunkan konsentrasi 8-OHdG pada urin tikus yang terpapar etanol selama 30 hari. Konsentrasi 8-OHdG pada perlakuan fraksi n-butanol dosis 50, 100, 150, dan 200 mg/kg bb, secara berturut-turut dapat diprediksi membutuhkan waktu selama 64, 66, 54, dan 32 hari agar konsentrasi 8-OHdG menjadi 0,3318 ng/mL. ABSTRACT : This study aims to determine the active fraction flavonoid compounds in mahoni seeds as the antioxidant in decreasing urinary concentration of 8-OHdG in rats after being exposed to ethanol. Total flavonoid test was conducted using spectrophotometry UV-Vis method showing that n-buthanol fraction has the highest flavonoid level of 41,73 mg/L. The measurement of urinary 8-OHdG concentration has been carried out by ELISA on wavelength of 450 nm. The results showed that the concentration of 8-OHdG with dose of 50, 100, 150, and 200 mg/kg of body weight decreased during 21 days in male rats after being exposed to ethanol. The 8-OHdG concentration after treatment with n-buthanol fractions with doses of 50, 100, 150, and 200 mg/kg of body weight was predicted to be 0,3318 ng/mL after 64, 66, 54, 31 days respectively.

ANALISIS 8-ISOPROSTAN DALAM URIN TIKUS JANTAN WISTAR SETELAH TERPAPAR ETANOL DAN ASAP ROKOK Agung Ari Chandra Wibawa; Ni Made Suaniti; Ni Komang Ariati
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 1 Januari 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The 8-isoprostane compound can be used for a biomarker of oxidative stress formed by lipid peroxidation in the form of arachidonic acid with free radical in the body. The purpose of this study was to analysis urinary 8-isoprostane in male Wistar rats after sub-acute exposer to ethanol and cigarette smoke. Extraction method used was solid phase extraction and the analysis was conducted by TLC and spectrophotodensitometry. The results showed that the 8-isoprostane compound was not detected in the male Wistar rat’s urine as control rats and in those exposed to cigarette smoke. The average concentrations of 8-Isoprostane in the male Wistar rat’s urine exposed to ethanol and combination of ethanol-cigarette were 1.519 ± 1,386 and 2.063 ± 1,308 ppm respectively.

Kapasitas Total Antioksidan Ekstrak Metanol Biji Kakao (Theobroma cacao. L) Dengan Metode Spektrofotometri Uv-Vis Agung Ari Chandra Wibawa
Hydrogen: Jurnal Kependidikan Kimia Vol 9, No 1 (2021): Hydrogen: Jurnal Kependidikan Kimia
Publisher : Universitas Pendidikan Mandalika Mataram

Antioxidant compounds is one of compounds are needed by the body to reduce free radicals. The ability of antioxidants to reduce free radicals is called antioxidant capacity. The purpose of this study was to provide information on the total antioxidant capacity of the methanol extract of cocoa beans with the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) method using spectrophotometer uv-vis. The crude extract obtained was extracted using methanol solvent by maceration method. The results of the phytochemical screening test on the methanol extract of cocoa beans showed the presence of flavonoids and tannins. The total antioxidant capacity test of cocoa bean extract used the standard equivalent value of gallic acid which has been shown to have a strong antioxidant ability to reduce DPPH free radicals at a wavelength of 517 nm. The results of the measurement of total antioxidant capacity in the variation of treatment, namely sun-dried cocoa beans and oven cocoa beans were 27.730 and 42.454 mg/mL GAEAC. Based on the results of this study, it was found that the ethanol extract of oven cocoa beans had the greatest total antioxidant capacity, namely 42.454 mg/mL GAEAC.

Molecular docking activity of peristrophe bivalvis on non small cell lung cancer Santoso, Puguh; Adrianta, Ketut Agus; Wibawa, Agung Ari Chandra; Gunawan, I Wayan Suardi Adi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Cancer is a genetic disease in which cells are unable to control their functions normally. As cancer develops, old cells will survive when they should die, and new cells will grow when they are not needed. These extra cells can divide endlessly and can form growths called tumors . This research was carried out to know whether peristrophine, apioside, and pelargonidin 3-Sambubioside compounds could be developed as a drug in Non-Small Cell Lung Cancer (NSCLC) with the in silico method at the ROS1 receptor with the Protein Data Bank code 3ZBF with the native ligand crizotinib. Peristrophine, apioside, and pelargonidin 3-Sambubioside compounds have an affinity for ROS1 protein with binding energies of -6.12 kcal/mol on peristrophine, -6.74 kcal/mol on apioside, and -7.54 kcal/mol of pelargonidin 3-Sambubioside. Peristrophine, apioside, and pelargonidin 3-Sambubioside have a molecular mechanism in inhibiting ROS1 in Non-Small Cell Lung Cancer (NSCLC) through the formation of hydrogen bonds in the protein ROS1. From Lipinski's analysis, the peristrophine test compound has met the requirements and seen from the LD50 value of the peristrophine test compound, apioside and pelargonidin 3-Sambubioside has the same toxicity class as the comparison compound, namely crizotinib at class 4 toxicity.

PEMBUATAN INFUSED WATER DAUN KAYU MANIS BALI (DAUN KATUK) DAN PEMANFAATANNYA BAGI KESEHATAN Ni Made Sukma Sanjiwani; Ni Putu Ayu Mirah Mariati; Agung Ari Chandra Wibawa; I Wayan Surya Rahadi; Dewa Ayu Ika Pramitha; I Wayan Sudiarsa
Jurnal Pengabdian Kepada Masyarakat Widya Mahadi Vol. 4 No. 1 (2023): Desember 2023
Publisher : LP3M Universitas PGRI Mahadewa Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59672/widyamahadi.v4i1.3391

Banjar abasan is one of the banjars in Singapadu village, Sukawati sub-district, Gianyar regency, Bali province, Indonesia, precisely located to the south of banjar kutri and to the north of banjar kebon. Cinnamon plants grow a lot in the homes of banjar abasan residents and most of the residents of banjar abasan do have cinnamon plants in their homes. The purpose of making cinnamon leaf infused water is to produce young men and women of banjar abasan to be able to make cinnamon leaf infused water which in the future can be used as a business or sold by young men and women of banjar abasan because seen from the potential of young men and women of banjar abasan who have the potential to be able to make cinnamon leaf infused water because cinnamon leaf infused water is very beneficial for health. In this service, assistance is provided to the banjar abasan community, especially young people and youths so that they can make and analyze the pH of cinnamon leaf infused water. Socialization and demonstration will be carried out in month 5 which begins with giving a pre-test, then a socialization session, a demonstration session for making cinnamon leaf infused water and testing the pH of cinnamon leaf infused water and ends with giving a post-test in order to hone community knowledge about this community service. This service is very beneficial for the abasan community because they are given knowledge related to cinnamon leaf infused water, the abasan community also gets knowledge on how to make cinnamon leaf infused water and pH testing of cinnamon leaf infused water, with the knowledge given, the abasan community knows and can make infused water independently with the assistance, socialization and demonstration program. The mandatory outputs that have been achieved in this research are: Video of activities on Youtube, news writing in print/electronic media, final report and learning integration.

Analysis Antioxidant of Fractions Cocoa Beans (Theobroma Cacao L.) as Potential Herbal Medicine Wibawa, Agung Ari Chandra; Pramitha, Dewa Ayu Ika; Sanjiwani, Ni Made Sukma; Adrianta, Ketut Agus
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12548

The cocoa seeds of the Gumbrih-Bali region are a natural commodity with great potential for development or processing by local communities. The purpose of this research is to provide information about the antioxidant potential contained in cocoa seeds. Testing the antioxidant capacity in this study uses the Uv-Vis spectrophotometry method at 517 nm wavelengths. Free radical scavanger is measured with control absorption and samples was analyzed with regression curve. The research results proved that the antioxidant (AAI) in the n-butanol fraction show result very strong ability of 4.64 compared to the 0.42 ethyl acetate fraction and 0.46 n-hexane fraction. These results prove that the potential chemical content of cocoa seeds is high in polar solvents (n-butanol fractions) such as flavonoid compounds. Furthermore, this research will be used as a basis for developing natural herbal ingredients such as cocoa which can be consumed in the community to prevent degenerative diseases.

PENGENALAN MANFAAT DAN PENGUJIAN pH JUS APEL FUJI DAN JUS ALPUKAT UNTUK KESEHATAN Ni Made Sukma Sanjiwani; I Wayan Sudiarsa; Ni Putu Ayu Mirah Mariati; Agung Ari Chandra Wibawa; I Wayan Surya Rahadi; Puguh Santoso
Jurnal Pengabdian Kepada Masyarakat Widya Mahadi Vol. 5 No. 1 (2024): Desember 2024
Publisher : LP3M Universitas PGRI Mahadewa Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59672/widyamahadi.v5i1.4307

One of the herbal drinks that have positive effects on health is juice. The chief executive of the community service decided to give an introduction to the banjar abasan community in Singapadu Tengah village because the abasan community pays less attention to their body health. They also do not know how to test the pH of fuji apple and avocado juice for health. In this service, an introduction to the benefits and negative effects of fuji apple and avocado juice was carried out in the form of socialisation and an introduction to making and testing the pH of fuji apple juice and avocado juice in the form of training demonstrations. This service begins with giving a pre-test and ends with giving a post-test in order to hone the community's knowledge related to the knowledge that has been given in this community service. This service is very beneficial for the abasan community because they are given knowledge related to apples and avocados and the negative effects of consuming them excessively and in the wrong time, the benefits of fuji apple juice and avocado juice. The abasan community also gained knowledge on how to make and test the pH of fuji apple juice and avocado juice and the benefits of testing the pH of the juice. Based on the results of the pretest and postest, most of the service participants really understood about this service and had a great desire to become avocado juice and fuji apple juice entrepreneurs because the manufacturing process was easy and the selling price was affordable.

PENGUJIAN AKTIVITAS ANTIOKSIDAN SHATA DHAUTA GHRITA DENGAN PENCUCIAN MENGGUNAKAN INFUSED WATER DAUN KAYU MANIS BALI Sanjiwani, Ni Made Sukma; Wibawa, Agung Ari Chandra; Rahadi, I Wayan Surya; Mariati, Ni Putu Ayu Mirah; Vinanda, Ketut Adelia; Pradnyandari, I Gusti Ayu Agung Ratih
Akta Kimia Indonesia Vol 9, No 2 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i2.19950

Shata Dhauta Ghrita (SDG) is a basic medicinal preparation for external use or cream. SDG originally had the definition of Ghrita washed a hundred times with water [14]. This study aims to make Shata Dhauta Ghrita with washing using greentea-scented cinnamon leaf infused water. Shata Dhauta Ghrita with washing using cinnamon leaf infused water with greentea aroma was analyzed for antioxidant activity and antioxidant testing optimization was carried out, namely looking for optimal conditions and results. In this study, infused water was made first, then butter, ghee and shata dhauta ghritanya were made, making shata dhauta ghritanya using washing with cinnamon leaf infused water and flavored with green tea. Testing antioxidant activity with DPPH method: Weighed 25 mg of sample dissolved with a little methanol p.a, then put into a 25 milliliter volumetric flask, the volume is sufficient to indicate the limit and homogenized (1000 µg/ml). 0.5 ml of filtrate was taken and 3.5 ml of 0.1 mM DPPH solution was added in the test tube. The test solution was allowed to stand for 30 minutes at room temperature and dark area then measured the absorbance at the maximum wavelength using UV-Vis spectrophotometer. The antioxidant activity test of shata dhauta ghrita has an IC50 value of 22,445.1 which means it has very strong antioxidant activity. This very strong antioxidant activity is because shata dhauta ghrita has active substances, namely flavonoids, because the washing uses cinnamon leaf infused water. Shata dhauta ghrita has an IC50 value of 22,445.1 which means it has very strong antioxidant activity.

PENGUJIAN pH, GUGUS FUNGSI DAN AKTIVITAS ANTIBAKTERI KRIM BERBAHAN VIRGIN COCONUT OIL (VCO) Sanjiwani, Ni Made Sukma; Wibawa, Agung Ari Chandra; Sudiarsa, I Wayan; Mirah Mariati, Ni Putu Ayu; Setya Cahyani, I Gusti Ayu Agung Dwita; Pramana, I Made Wisnu Yoga
Akta Kimia Indonesia Vol 10, No 1 (2025)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v10i1.22603

This study aims to determine the pH, determine the functional groups and determine the diameter of the inhibition zone of cream made from VCO. In this study, cream was made with 2 formulations, formula 1 with 15% VCO concentration and formula 2 with 20% VCO concentration. In making the cream, all the ingredients that will be used were weighed first. The oil phase (VCO, vaselin album, stearic acid, span 60, and propyl paraben) was heated to 70°C. The water phase (glycerin, methyl paraben, tween 80, and distilled water) was heated to 70°C. The water phase was gradually incorporated into the oil phase at 70°C. It was then homogenised at 2000 rpm for 15 minutes to cool. Both cream formulas were analysed for pH, functional groups and antibacterial activity. The pH of VCO-based cream in formula 1 has an average pH value of 5.91 and formula 2 has an average pH value of 6.03, so each cream sample has an acidity level with a range of 4.5-6.5. The functional groups found in VCO-based cream formulas 1 and 2 are: C-H bending, C=C stretch (aliphatic and aromatic); C=N, C=O stretch (acids, aldehydes, ketones, amides, esters, anhydrides), CΞC stretch; CΞN, C-H stretch: CH3; CH2, Stretch C-H: C-H; C=C-H; Ar-H. In the range of numbers 3750 - 3000 cm-1 there are functional groups O-H; N-H. Waves 3000-1000 cm-1 have a sharp band shape and strong intensity. The wavenumber 3700-3100 cm-1 has a wide band shape and strong intensity. F2 cream has a larger inhibition zone diameter than F1 cream. The diameter of the inhibition zone of cream F2 is largest at a concentration of 10%, the greater the concentration the less the diameter of the inhibition zone.

Co-Authors Arandika, I Wayan Wisma Dewa Ayu Ika Pramitha Gunawan, I Wayan Suardi Adi I Made Dedy Ariawan I Made Dira Swantara I WAYAN SUDIARSA I Wayan Surya Rahadi Ketut Agus Adrianta Manuntun Manurung Megawati, Fitria Ni Komang Ariati Ni Made Suaniti Ni Made Sukma Sanjiwani Ni Putu Ayu Mirah Mariati NI PUTU AYU MIRAH MARIATI Ni Wayan Trisna Dewi P Purwanto Paramitha, Dewa Ayu Ika Pradnyandari, I Gusti Ayu Agung Ratih Pramana, I Made Wisnu Yoga Puguh Santoso puguh santoso, puguh Putu Era Sandhi Kusuma Yuda Rahadi, I Wayan Surya Samidya, Ni Wayan Rias Sanjiwani, Ni Made Sukma Sari, Ni Wayan Suryani Puspita Setya Cahyani, I Gusti Ayu Agung Dwita Vinanda, Ketut Adelia

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