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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Eastasouth Management and Business
Putri, Suci Rahmawati
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Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Medicine & Pharmacology

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Pemodelan Homologi Protein Receptor Orphan Receptor-1 (ROR-1) Sebagai Target Terapi Chronic Lymphocytic Leukemia (CLL Ruslin, R; Putri, Suci Rahmawati; Arba, Muhammad
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 5, No 1 (2019): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v5i1.8992

Abstract

Receptor Orphan Reseptor-1 (ROR-1) is a trans-membrane protein consists of 937 amino acid residues located on 1p31.3 chomosome. ROR-1 has an important role in leukemogenesis of CLL cells. Co-expressions of ROR-1 and TCL enhance leukemogenesis and caused AKT’s phosphorylation, cell’s proliferations, and resistances to apoptosis. This study had done physicochemical characteristics analysis, secondary structure and tertiary structure prediction of ROR-1 Protein using few types of bioinformation tools. The physicochemical characteristics analysis was done by using Expasy Protparam server and the prediction of secondary structure was using Sopma and Psipred. The prediction of ROR-1’s tertiary structure was done by using Modeller 9.19 software  and resulting five ROR-1’s tertiary structures predicted model. The accuration of the results then evaluated using Ramachandran’s plot analysis and it was showed Model 3 is the best models wich percentage is 82%.Keywords: ROR-1, Choronic Lymphocytic Leukemia (CLL), homology modeling, Modeller, Ramachandran plot
Barriers Barriers to the Growth of Food and Beverage MSMEs in Surabaya: A Strategic Analysis of Production and Marketing Challenges Siswati, Endang; Rasharenda, Abrorri; Putri, Chelli Sagita; Putri, Suci Rahmawati; P, Wisnu Nur Alif
The Eastasouth Management and Business Vol. 4 No. 01 (2025): The Eastasouth Management and Business (ESMB)
Publisher : Eastasouth Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/esmb.v4i01.643

Abstract

The purpose of this study was to determine the factors that inhibit the growth of food and beverage MSMEs in Surabaya in terms of production and marketing. Using a qualitative descriptive approach. The informants in this study were 9 MSMEs in the city of Surabaya. Data collection was carried out using documentation and in-depth interviews with MSME actors, direct observation of activities, production and marketing, Data analysis was carried out using techniques (Miles & Huberman, 1994), the results of the study found that MSME obstacles in the production process include other capital that is still minimal can affect business development, the production process is still simple can have an impact on slow efficiency in the production process, fluctuating raw materials make it difficult for micro business actors to make production and price plans, and lack of managerial knowledge in the business. The obstacles led by micro food and beverage entrepreneurs in the product marketing function are that marketing is still limited to the environment around the business, lack of promotion and minimal product packaging that inhibits business growth. Digital marketing strategies on social media can be used as an effective promotional strategy at an affordable cost to expand market share. The results of the study resulted in: producing 2 groups of MSME levels, namely strong and weak survival groups. Strong MSMEs have the criteria of large turnover with a balanced ratio of the number of employees to their turnover, while weak MSMEs have the criteria of relatively large turnover but with an unbalanced ratio of the number of employees to their turnover.
Co-Authors Arba, Muhammad P, Wisnu Nur Alif Putri, Chelli Sagita Rasharenda, Abrorri Ruslin, R Siswati, Endang