Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Mayasari, Ayudiah Puspita
Unknown Affiliation
Health Professions Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Neutrophil-Lymphocyte Ratio, Platelet Lymphocyte Ratio, And Carcinoembryonic Antigen Relationship With Survival In Non-Small Cell Lung Cancer Patients Haryati, Haryati; Mayasari, Ayudiah Puspita; Heriyani, Farida
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22773

Abstract

Inflammation is crucial to cancer development. A complete blood count is standard patient testing. Thus, inflammatory biomarkers like neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) may predict lung cancer prognosis. Serum carcinoembryonic antigen (CEA) is the main predictive marker of most studies. Elevated NLR, PLR, and CEA levels are frequently associated with poorer overall survival in NSCLC patients. A retrospective cross-sectional study included 50 NSCLC medical records patients from Ulin Regional South Kalimantan Hospital. NLR, PLR, and CEA baseline peripheral blood individuals were investigated for NSCLC overall survival (OS). Patients are separated by OS mean into two groups. Mann-Whitney compared variables. The ROC curve and AUC were used to evaluate the above indicators' prognostic value. The mean of OS was 6 months. NLR, PLR, and CEA patients in ≤ 6 months had higher median values compared to > 6 months groups (8.73 vs. 4.3; 301.23 vs. 217.81; and 106 vs. 27.87). Survival was significantly associated with NLR and CEA (p-values 0.010 and 0.011). NLR >5.90 with AUC 0.725 (sensitivity 63.6%, specificity 29.4%) and CEA >41.39 ng/mL with AUC 0.722 (sensitivity 72.7%, specificity 29.4%). Parallel tests of NLR and CEA testing increased sensitivity and specificity (75.8%, 70.6%). This study revealed that elevated NLR and CEA are associated with patient survival, and monitoring both markers enhances survival prediction accuracy. It can improve insight into disease progression and adjust the therapeutic approach for NSCLC patients.
Co-Authors Farida Heriyani Haryati Haryati