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All Journal COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Penyakit Dalam Indonesia Cermin Dunia Kedokteran
Purnami, Ni Ketut Rai
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Humanities Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Social Sciences

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Low Serum Irisin as A Risk Factor of Sarcopenia in Elderly Aryana, I Gust Putu Suka; Putrawan, I.B.; Purnami, Ni Ketut Rai; Kuswardhani, R.A. Tuty; Astika, I Nyoman; Suastika, Ketut; Adiatmika, I Putu Gede; Jawi, I Made; Wande, I Nyoman
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Sarcopenia is a condition characterized by a decrease in muscle mass accompanied by a decrease in strength and/or function. Sarcopenia is closely related to the aging process, but the mechanism of its occurrence is still not fully understood. Skeletal muscle is the largest organ in the human body, so the myokine produced through muscle contraction opens a new paradigm regarding the central role of muscles in regulating metabolism and other organ functions. One of the myokines that are currently found to affect physical activity is Irisin. This study aims to determine the role of low Irisin levels in serum as a risk factor for sarcopenia in the elderly. Methods. This case-control study was conducted in Denpasar City from January 2020 to October 2020. The sample was selected using purposive consecutive sampling with matching age and gender, with 54 subjects, 27 case groups, and 27 control groups aged ≥60 years. Sarcopenia status is enforced by the criteria of the Asian Working Group for Sarcopenia (AWGS). Irisin serum levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Based on 54 subjects, the mean age in cases was 69.79 (SD 5.00) years and controls 67.89 (SD 4.50) years (p = 0.152), the proportion of male:female both in cases and controls group was 9:18. The cut-off point value wass based on the irisin ROC curve 4.51 ng/L. Nutritional status (OR = 3.40 (95% CI = 1.11 - 10.40); p = 0.029) and irisin (OR = 25.30 (95% CI = 6,00 - 106.66); p = <0.001) had an effect on sarcopenia. Factors that purely influence sarcopenia were found in low irisin (OR = 103.41 (95% CI = 7.83 – 1,364.99; p = <0.001). Conclusions. Low Irisin level is a risk factor for sarcopenia in the elderly. Irisin could be considered for further investigation in an effort to become a target for both preventive and curative therapy for sarcopenia.
Perbedaan Kejadian Sepsis Berdasarkan Status Frailty Pada Pasien Lanjut Usia Rawat Inap di RSUP Prof. dr. I.G.N.G. Ngoerah Putra, I Gede Wahyu Pratama; Purnami, Ni Ketut Rai
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3187

Abstract

Perbedaan Kejadian Sepsis Berdasarkan Status Frailty Pada Pasien Lanjut Usia Rawat Inap di RSUP Prof. dr. I.G.N.G. Ngoerah Putra, I Gede Wahyu Pratama; Purnami, Ni Ketut Rai
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3187

Abstract

Lanjut Usia dengan Infark Miokard Akut yang Diduga Dicetuskan oleh Hospital-Acquired Pneumonia - Laporan Kasus: Laporan Kasus Hardika, Putu Stephanie Apriliana; Purnami, Ni Ketut Rai
Cermin Dunia Kedokteran Vol 53 No 04 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i04.1866

Abstract

Introduction: Pneumonia can trigger acute cardiovascular events (CVE) in elderly. Risk for subsequent CVE can occur even years after pneumonia. Case: A 75-year-old male was hospitalized with chief complaint of diarrhea. During hospitalization, he complained of black stools, accompanied by cough with white phlegm, fever, and shortness of breath. As he developed into Hospital-Acquired pneumonia (HAP), he was also diagnosed as atypical angina. His electrocardiography (ECG) underwent evolution into ST elevation at lead II, III, and aVF, as well as the increasing cardiac biomarker level. The patient was diagnosed with inferior ST elevation myocardial infarction (STEMI) Killip III, intestinal amoebiasis, melena suspected caused by peptic ulcer dd/ colitis amoebiasis, moderate normochromic normocytic anemia, late onset hospital-acquired pneumonia (HAP), and acute kidney injury (AKI) stage II dd/ prerenal acute on chronic kidney disease (ACKD) caused by suspected chronic pyelonephritis dd/ nephrosclerosis. Discussion: The suspicion of pneumonia as a trigger for STEMI can be seen from the clinical manifestation of infection and the presence of significant increase in leucocytes as a marker of infection. Afterseveral days of treatment He was treated in an intensive cardiac care unit with antiplatelet and anti- angina therapy, the patient’s condition improved. Conclusion: The mechanisms underlying cardiovascular events triggered by pneumonia remain unclear. Adequate therapy playsa crucial role in the management of pneumonia.
Co-Authors Aryana, I Gust Putu Suka Astika, I Nyoman Hardika, Putu Stephanie Apriliana I Ketut Suastika I Made Jawi I Nyoman Wande I P G. Adiatmika Ida Bagus Putu Putrawan Putra, I Gede Wahyu Pratama R. A.T. Kuswardhani