Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Media Farmasi Pharmacon: Jurnal Farmasi Indonesia
Pramesthi, Asri Dwi Endah Dewi
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
In-Silico Analysis of Momordica charantia L. As Antidiabetic Agents Through Activation of Human UDP-Galactose 4-Epimerase Receptors Pramesthi, Asri Dwi Endah Dewi; Suwarno, Kafka Navisa; Pratama, Aldo; Rasyidah, Jamiatur; I Wayan Surya Rahadi; Rasida, Rima
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1002

Abstract

This study investigates the antidiabetic potential of compounds found in Momordica charantia L., commonly known as bitter melon, through molecular docking and ADME (Absorption, Distribution, Metabolism, and Excretion) analysis. Utilizing in silico methods, several bioactive compounds from bitter melon, such as charantin, vicine, momordenol, momordicilin, and momordicoside, were evaluated for their ability to interact with the human UDP-Galactose 4-Epimerase receptor, a key enzyme involved in glucose metabolism. The docking results indicate that these compounds exhibit strong binding affinities, suggesting their role in glucose regulation. Further ADME analysis revealed that the compounds generally comply with the Lipinski Rule of Five, indicating favorable drug-like properties, though some compounds exhibited potential toxicities requiring further investigation. These findings highlight the potential of Momordica charantia as a source of antidiabetic agents, warranting additional in vivo and clinical studies to confirm their efficacy and safety in managing diabetes mellitus.
In Silico Analysis of Momordica charantia L. as Antidiabetic Agents of GSK-3β Receptors and It's Antioxidant Activity Pramesthi, Asri Dwi Endah Dewi; Khairunnisa, Khairunnisa
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.13447

Abstract

-
Co-Authors I Wayan Surya Rahadi Khairunnisa Khairunnisa Pratama, Aldo Rasida, Rima Rasyidah, Jamiatur Suwarno, Kafka Navisa