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All Journal Jurnal Medik Veteriner Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH
Vita, Angelica Diana
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health Veterinary

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Efek Antidiabetik Ekstrak Daun Gendola (Basella rubra L.) Terhadap Kadar Gula Darah Tikus Putih Vita, Angelica Diana; Fatimah, Nurmawati; Murtiwi, Sri
Jurnal Medik Veteriner Vol. 2 No. 2 (2019): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.853 KB) | DOI: 10.20473/jmv.vol2.iss2.2019.127-132

Abstract

Penelitian bertujuan untuk menguji efek antidiabetik ekstrak daun gondola (Basella rubra L.) pada kadar gula darah tikus putih (Rattus norvegicus) yang diinduksi Alloxan. Penelitian ini merupakan penelitian eksperimen dengan menggunakan 35 ekor tikus putih. Tikus tersebut dibagi menjadi lima kelompok perlakuan, yakni: P1; P2; P3; kontrol negatif (K-); dan kontrol positif (K+). Masing-masing kelompok diinduksi menggunakan Alloxan untuk meningkatakan kadar gula darah. Kelompok P1; P2; P3 diberi ekstrak daun gendola dengan dosis 200; 300; 400 mg/kgBB/hari. Kelompok K+ diberi obat glimepirid 0.1 mg/kgBB/hari. Kelompok P1 mengalami penurunan kadar gula darah yang tidak signifikan sebesar 30.14 mg/dL (p-value=0.128); kelompok P2 mengalami penurunan kadar gula darah tidak signifikan sebesar 25.80 mg/dL (p-value=0.159); kelompok P3 mengalami penurunan kadar gula darah yang signifikan sebesar 42.80 mg/dL (p-value=0.043). Kelompok kontrol negatif mengalami peningkatan kadar gula darah sebesar 116.00 mg/dL (p-value=0.084). Kelompok kontrol positif mengalami penurunan kadar gula darah yang signifikan sebesar 21.60 mg/dL (p-value=0.011). Ekstrak daun gendola 400 mg/kgBB/hari dapat menurunkan kadar gula darah tikus dengan perbedaan tidak signifikan apabila dibandingkan dengan obat antidiabetes glimepirid 0.1 mg/kgBB/hari.
COMPARISON OF MORTALITY BETWEEN THE COMBINATION OF STANDARD THERAPY AND CONVALESCENT PLASMA THERAPY AND STANDARD THERAPY ONLY IN COVID-19 PATIENTS : SYSTEMATIC REVIEW AND META-ANALYSIS Klarin, Felicia; Vita, Angelica Diana; Siahaan, Cynthia Elvira Sari; Rifdah, Salsabila Nabilah; Putri, Ayu Rahmanita; Kusuma, Indriasti Putri; Prayitno, Subur
Journal of Community Medicine and Public Health Research Vol. 2 No. 2 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.579 KB) | DOI: 10.20473/jcmphr.v2i2.27432

Abstract

Coronavirus Disease-19 (COVID-19) is an infectious disease caused by a newly discovered type of coronavirus. Comprehensive management for COVID-19 patients includes infection control, hemodynamic stability maintenance, oxygenation monitoring, ventilation, and pharmacotherapy administration. Convalescent plasma is one of the COVID-19 therapy choices, proven to provide relief for Ebola, SARS, and MERS patients. Therefore, the authors believed in searching data on whether convalescent plasma therapy also improves COVID-19 patients, specifically in terms of mortality. This study aims to compare the comparison in mortality between standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients. This study used a systematic review and meta-analysis method according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This study used ten studies that met the inclusion criteria to evaluate the comparison in mortality between the combination therapy with standard therapy only in COVID-19 patients. There was a significant difference in mortality between the combination of standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients, and mortality in the combination therapy groups being lower than standard therapy only.
Laporan Kasus Berbasis Bukti: Dapatkah Indeks Mentzer Membimbing Diagnosis Anemia Mikrositik di Daerah Rural Indonesia? Vita, Angelica Diana; Bernardinus Realino Nara, Mario
Majalah Kedokteran Indonesia Vol 75 No 4 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.4-2025-1930

Abstract

Introduction: Indonesia, part of the “Thalassemia Belt,” carries a significant burden of hemoglobinopathies, with β-thalassemia trait (BTT) affecting up to 10% of the population. In rural settings with limited access to advanced diagnostics, distinguishing between BTT and iron deficiency anemia (IDA) using clinical and hematologic indices such as the Mentzer Index may aid early management.Method: A structured literature search was conducted in MEDLINE and EBSCO to identify diagnostic or cross-sectional studies comparing red blood cell indices, particularly the Mentzer Index, in differentiating IDA from BTT. Studies were selected based on inclusion and exclusion criteria, and full texts were critically appraised by three reviewers using criteria of validity, importance, and applicability.Results: Six studies with Level 4 evidence were included. The Mentzer Index was evaluated in all studies, with sensitivity ranging from 66% to 100% and specificity from 47.1% to 100%. Rashwan et al. and Jasim et al. reported perfect or near-perfect accuracy, while Indrasari et al., an Indonesian study, found more modest results (sensitivity 66%, specificity 62.5%). Variability in diagnostic performance may be influenced by population genetics, disease spectrum, and laboratory techniques.Conclusion: The Mentzer Index demonstrates promising diagnostic value, particularly in settings where advanced testing is unavailable. However, variability in its accuracy across populations suggests that clinical judgment remains essential. The Mentzer Index can be a useful preliminary tool but should not replace confirmatory tests when available.
Early Management of Aspiration Pneumonia in an Infant With Suspected Laryngomalacia in A Resource-Limited Setting: A Case Report Vita, Angelica Diana; Mahyuddin, Muhammad Hanun; Saraswati, Dian
Journal of Community Medicine and Public Health Research Vol. 6 No. 2 (2025): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v6i2.70171

Abstract

Laryngomalacia is the most common cause of congenital stridor in infants and can lead to feeding difficulties, failure to thrive, and respiratory distress. Diagnosis typically requires flexible fiberoptic laryngoscopy, which more often than not, not available in resource-limited settings. We report a 12-day-old male infant who presented to the emergency department with apnea following a choking episode. He required cardiopulmonary resuscitation and was admitted to the neonatal intensive care unit. Clinical findings included chest retractions, cyanosis, weight loss (from 3500g at birth to 2700g), and feeding difficulties. Chest radiograph showed right-sided perihilar infiltrates consistent with aspiration pneumonia. Despite initial clinical improvement, the infant developed new-onset positional stridor on day ten of hospitalization, particularly when supine. These findings raised strong suspicion of underlying laryngomalacia. These signs raised a strong clinical suspicion of laryngomalacia. Due to absence of flexible fiberoptic laryngoscopy, diagnosis could not be confirmed. The infant was stabilised with supportive care and feeding adjustments before being referred to a tertiary center for definitive evaluation and management. This case highlights the importance of prompt recognition and early stabilisation of neonates with aspiration-related complications and suspected airway anomalies, particularly in low-resource settings. Timely referral is essential to prevent deterioration and guide appropriate long-term management.
Co-Authors Bernardinus Realino Nara, Mario Dian Saraswati Fatimah, Nurmawati Klarin, Felicia Kusuma, Indriasti Putri Mahyuddin, Muhammad Hanun Prayitno, Subur Putri, Ayu Rahmanita Rifdah, Salsabila Nabilah Siahaan, Cynthia Elvira Sari Sri Murtiwi