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All Journal Indonesian Journal of Pharmaceutical Science and Technology Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) International Journal of Global Operations Research Medical Sains : Jurnal Ilmiah Kefarmasian
Vitamia, Cszahreyloren
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Health Professions Mathematics Medicine & Pharmacology Nursing Public Health

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Citronella (Cymbopogon nardus (L.) Rendle) Leaves Infusion: Sedative Activity in Swiss-Webster Strain Male Mice Vitamia, Cszahreyloren; Handayani, Wahyuni Mega
International Journal of Global Operations Research Vol. 5 No. 1 (2024): International Journal of Global Operations Research (IJGOR), February 2024
Publisher : iora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47194/ijgor.v5i1.289

Abstract

Insomnia is one of the sleep disorders and more severe symptoms can culminate in the onset of stress disorder. The high threat of being affected by COVID-19 causes insomnia, so drugs such as sedatives are required to treat this disorder. Research has been carried out on the sedative activity of infusion of citronella leaves (Cymbopogon nardus (L.) Rendle) in Swiss webster strains of male mice by the traction test method. The study used twenty-five mice randomly divided into five groups. Each group was given different preparations such as negative control given Na CMC 0.5%, the positive control group was given suspension of diazepam and the infusion group of citronella leaves with concentrations of 10% w/v, 30% w/v and 50% w/v as the test groups sequentially. The results showed that citronella leaves infusion had increased sedative activity along with in conjunction with an increment in test concentration. The infusion concentration of citronella leaves that have maximum sedative activity was found at a concentration of 50% w/v in the variations tested and have significantly different results compared to the control group.
Aktivitas Hemostatik Lokal Beberapa Varietas Getah Batang Pohon Pisang (Musa parasidiaca) Vitamia, Cszahreyloren; Nuryanti, Ayu N
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.50661

Abstract

AbstrakMasyarakat Indonesia telah menjunjung tinggi tradisi penggunaan  herbal secara turun-temurun, dan salah satu contoh yang menonjol adalah pemanfaatan pohon pisang (Musa paradisiaca) untuk khasiat pengobatannya. Oleh karena itu, telah dilakukan penelitian untuk menilai aktivitas hemostatik lokal berbagai jenis getah batang semu pisang dengan mengukur waktu pendarahan pada hewan percobaan. Penelitian ini menggunakan metode Duke, dengan memberikan luka ringan pada ekor tikus. Tikus Swiss Webster jantan dibagi menjadi lima kelompok. Hasilnya, rata-rata ± SD waktu pendarahan pada kelima kelompok adalah sebagai berikut: kelompok kontrol negatif, kontrol positif, dan perlakuan dengan getah batang semu pisang ambon, nangka-pisang, dan pisang siem berturut-turut 305,40 ± 79,45; 88,00±29,45; 81,20 ± 91,19; 199,20 ± 64,77; dan 135,40 ± 31,19 detik. Data yang terkumpul dilakukan analisis statistik ANOVA yang dilanjutkan dengan uji LSD. Secara signifikan, terdapat perbedaan antara kelompok kontrol negatif dan kelompok perlakuan lainnya di antara kelima kelompok. Namun tidak terdapat perbedaan nyata antara ketiga kelompok perlakuan yang melibatkan berbagai varietas getah batang pohon pisang. Penelitian mengungkapkan bahwa getah batang pisang semu dapat secara efektif mengurangi waktu pendarahan pada tikus.
Identifikasi Drug-Related Problems (DRPs) pada Terapi Pasien Diabetes Melitus Rawat Jalan di Klinik Swasta Kabupaten Sumedang Vitamia, Cszahreyloren; Yusnita, Adinda
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 8 No. 2 (2024): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51873/jhhs.v8i2.345

Abstract

Latar belakang: Diabetes melitus merupakan penyakit tidak menular yang merupakan satu dari banyak penyakit degeneratif yang paling umum menyebabkan kematian di Indonesia. Salah satu wujud usaha yang bisa dilakukan tenaga kesehatan untuk mengurangi persentase kejadiannya adalah dengan dilakukannya pengkajian resep yang berguna untuk menghindari terjadinya drug related problems yang berpotensi menyebabkan tidak tercapainya hasil terapi yang optimal. Tujuan penelitian: mengidentifikasi dan menentukan karakteristik potensi kejadian DRPs pada pasien dengan terapi diabetes melitus di salah satu klinik swasta di kabupaten Sumedang. Metode penelitian: penelitian ini merupakan penelitian deskriptif dengan menggunakan metode total sampling secara retrospektif pada 100 rekam medis pasien pada periode Mei sampai Juli 2024. Identifikasi DRPs menggunakan klasifikasi DRPs Cipolle/Morley/Strand Hasil: Diperoleh hasil pasien diabetes melitus terbanyak adalah wanita(83%) dan profil usia penderita terbanyak ada pada rentang umur 45-59 tahun sebesar 52%. Obat antihiperglikemik yang diresepkan dengan prevalensi tertinggi kombinasi obat oral antidiabetes yaitu golongan biguanida dan sulfonilurea (metformin+glimepiride) sebanyak 41,82%. Potensi kasus DRPs ditemukan di 28 rekam medis pasien rawat jalan dengan kategori DRPs tidak butuh obat (50%), butuh obat (21,4%), dosis kurang (14,3%), terapi tidak efektif (10,7%), dan kategori DRPs dosis berlebih(3,6%). Simpulan: Potensi kejadian DRPs ditemukan pada 28 dari 100 rekam medis pasien yang digunakan sebagai data penelitian. DRPs kategori tidak butuh obat merupakan kasus dengan kategori potensi DRPs terbanyak dengan total sebanyak 14 kasus (50%).
ARTICLE REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF LOBI-LOBI FRUIT (Flacourtia inermis, Roxb) Adiwinata, Much Cheril Wicaksono; Vitamia, Cszahreyloren
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1665

Abstract

The Lobi-lobi fruit is a tropical plant that is rich in secondary metabolites. Many studies have discussed the usefulness of secondary metabolites in this fruit. This study aimed to explore the secondary metabolites and pharmacological activities of lobi-lobi fruit (Flacourtia inermis, Roxb). The methods used included a literature review of various scientific journals discussing the health potential of fruits. The results showed that the lobi-lobi fruit extract had significant antioxidant activity with an IC50 value of 104.223 ?g/mL, and showed potential as an antidiabetic and antibacterial agent. This discussion highlights the importance of bioactive components, such as phenolics, for providing therapeutic effects. The conclusion shows that this fruit has potential as a source of natural medicine and requires further research. Keywords: secondary metabolites, flacourtia inermis, pharmacological activity
ARTICLE REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF LOBI-LOBI FRUIT (Flacourtia inermis, Roxb) Adiwinata, Much Cheril Wicaksono; Vitamia, Cszahreyloren
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1665

Abstract

The Lobi-lobi fruit is a tropical plant that is rich in secondary metabolites. Many studies have discussed the usefulness of secondary metabolites in this fruit. This study aimed to explore the secondary metabolites and pharmacological activities of lobi-lobi fruit (Flacourtia inermis, Roxb). The methods used included a literature review of various scientific journals discussing the health potential of fruits. The results showed that the lobi-lobi fruit extract had significant antioxidant activity with an IC50 value of 104.223 ?g/mL, and showed potential as an antidiabetic and antibacterial agent. This discussion highlights the importance of bioactive components, such as phenolics, for providing therapeutic effects. The conclusion shows that this fruit has potential as a source of natural medicine and requires further research. Keywords: secondary metabolites, flacourtia inermis, pharmacological activity
Co-Authors Adiwinata, Much Cheril Wicaksono Handayani, Wahyuni Mega Nuryanti, Ayu N Yusnita, Adinda