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All Journal International Journal of Cell and Biomedical Science BUMI: International Journal of Environmental Reviews
Ari, Psn Masruri Sulistiyanto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Energy Environmental Science Immunology & microbiology Medicine & Pharmacology

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Soil Fertility Analysis using Microarthropod Diversity Index in Coffee-Based Agroforestry in Mount Ungaran, Indonesia Ari, Psn Masruri Sulistiyanto; Alkian, Ilham; Rahadian, Rully
BUMI: International Journal of Environmental Reviews Vol. 1 No. 02 (2023): BUMI: International Journal of Environmental Reviews
Publisher : UIN Sulthan Thaha Saifuddin Jambi, Pusat Kajian Lingungan Hidup

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30631/bumi.v1i02.2223

Abstract

The conversion of forest functions to plantation land results in decreased land function and ecosystem disruption. Coffee-based agroforestry is a management system that is considered capable of maintaining land functions and reducing the level of leaching of nutrients. This study uses the soil microarthropod diversity index to evaluate the soil fertility level in 2 types of coffee-based agroforestry in Mount Ungaran. Sampling was conducted in Banyuwindu to represent intensive land and Gonoharjo as non-intensive land. Microarthropod samples in the soil were analyzed using Pitfall traps and extracted using the Tullgren-Funnel method. Soil microarthropods from the sampling were identified in family-level taxa. The species diversity index was analyzed using the Hutcheson t-test and the Sorensen similarity index. Characteristics of organic composition showed that intensive land had a value of 17% lower than non-intensive land. Environmental characteristics of intensive land types tend to have lower pH and soil moisture values ​​than non-intensive land. The Shanon-Wiener diversity index analysis showed that soil microarthropods on the Intensive land type were H'= 2.08 and the Non-Intensive was H'= 2.30. Hutcheson's t-test showed that the diversity of soil microarthropods was significantly different with a significant value (p-value < 0.05), and the Sorensen similarity index value showed a similarity level of 52.17%. Based on the results of various analyses, it can be concluded that the intensive type of land has lower soil fertility than non-intensive land in the coffee agroforestry system in Mount Ungaran.
Anticancer effectiveness of Artemisia annua ethanol extract against MDAMB-231 cancer cells Agustina, Rita; Ari, Psn Masruri Sulistiyanto; Sadikin, Nadya Audina N
International Journal of Cell and Biomedical Science Vol 4 No 10 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i10.68

Abstract

Background: Breast cancer remains one of the leading causes of cancer deaths worldwide, with triple-negative breast cancer (TNBC) posing a significant therapeutic challenge due to its lack of hormonal receptors and resistance to conventional treatment. Artemisia annua L., a medicinal plant traditionally used in Chinese medicine, has received attention for its diverse bioactive compounds, including flavonoids, phenolic acids, and sesquiterpene lactones, which exhibit potential anticancer properties. This study aims to evaluate the in vitro cytotoxic effect of A. annua ethanol extract against MDA-MB-231 human breast cancer cells using the MTT assay. Methods: Extracts were prepared in 10% DMSO and tested at concentrations ranging from 0 to 1000 µg/mL. MDA-MB-231 cells were seeded in 96-well plates and incubated for 24 h before treatment. Post-treatment, cell viability was assessed via MTT assay, and absorbance was measured at 595 nm. The percentage of cytotoxicity was calculated, and the IC₅₀ value was determined through linear regression analysis. Results: The results showed a clear cytotoxic response depending on the dose, with the extract achieving an IC₅₀ value of 56.83 µg·mL-¹ indicating a fairly strong correlation between concentration and cytotoxicity. These findings indicate that A. annua contains bioactive compounds that are able to inhibit cancer cell proliferation. Conclusion: In conclusion, Artemisia annua ethanol extract showed moderate cytotoxic activity against MDA-MB-231 cells, supporting its potential as a complementary therapeutic agent for TNBC. Further studies are needed to elucidate its molecular mechanisms and evaluate its efficacy in vivo.
Synergistic Effects of Honey and Herbal Bioactives in Cancer Suppression Aprilia, Waheni Rizki; Hidayah, Nurul; Ari, Psn Masruri Sulistiyanto
International Journal of Cell and Biomedical Science Vol 4 No 11 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i11.73

Abstract

Natural bioactives from medicinal plants and honey possess remarkable antioxidant and anticancer properties. However, limited studies have evaluated their synergistic efficacy as combination formulations. This study aimed to develop and characterize a honey–herbal formulation with potential anticancer activity against human breast cancer cells (MDAMB) while ensuring minimal cytotoxicity toward non-cancerous mesenchymal stem cells (MSCs). The formulation was prepared by blending ethanolic herbal extract with pure natural honey in optimized ratios. Organoleptic characteristics were assessed by sensory evaluation. Antioxidant capacity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Organoleptic analysis showed acceptable color, aroma, texture, and pH profiles. The honey exhibited strong antioxidant (IC₅₀ = 60 ± 0.7 ppm) compared with external honey and others sample. The formulation demonstrates potential as a functional nutraceutical or adjunctive natural therapy for breast cancer management, warranting further in vivo and molecular pathway investigations.
Co-Authors Agustina, Rita Alkian, Ilham Aprilia, Waheni Rizki Nurul Hidayah Rully Rahadian Sadikin, Nadya Audina N