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All Journal Jurnal Ilmu Kedokteran dan Kesehatan International Journal of Clinical Inventions and Medical Sciences (IJCIMS) International Journal of Cell and Biomedical Science Jurnal Sistem Informasi dan Manajemen
Agustina, Rita
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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HUBUNGAN TINGKAT PENGETAHUAN IBU TENTANG MAKANAN SEHAT DAN STATUS SOSIAL EKONOMI KELUARGA DENGAN KEJADIAN KARIES DENTIS PADA ANAK SEKOLAH DASAR DI KECAMATAN TANJUNG SENANG BANDAR LAMPUNG Fadilla, Mirafzur Haris; Agustina, Rita; Mustofa, Festy Ladyani; Sjahriani, Tessa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 9 (2023): Volume 10 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i10.9899

Abstract

Dental caries is a disease that affects about 90% of children. According to Suwelod, caries is influenced by external and internal factors. One component of external factors is the behavior of maintaining dental health as measured by the level of knowledge of the mother and socioeconomic status. Knowing the relationship between the level of knowledge of the mother and the socio-economic status of the family in elementary school children in the Tanjung Bahagia District, Bandar Lampung City. This type of research is quantitative analytic with cross-sectional research design, patience and self-efficacy questionnaire with stratified random sampling technique. There were 100 mothers with good level of knowledge, 58 children (58%), the highest socioeconomic status level in the <UMR category, 74 respondents (74%), the highest incidence of dental caries was experienced by dental caries, namely 72 children (72 %) Statistical analysis used the chi-square test on the frequency of consumption of packaged milk and the incidence of dental caries with a value of p = 0.735 and a correlation value of OR = 1.169, on the level of knowledge of mothers and the incidence of dental caries. with a value of p = 0.06 and a correlation value of OR = 2.459. There is no significant relationship between the level of knowledge of the mother and the incidence of caries, however, there is a significant relationship between socioeconomic status and the incidence of caries in elementary school children in Tanjung Bahagia District, Bandar Lampung
HUBUNGAN FREKUENSI KONSUMSI SUSU KEMASAN DAN STATUS KEBERSIHAN GIGI DENGAN KEJADIAN KARIES GIGI PADA ANAK SEKOLAH DASAR DI KECAMATAN TANJUNG SENANG BANDAR LAMPUNG Hadi, Dimas Surya; Utami, Deviana; Agustina, Rita; Sjahriani, Tessa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 9 (2023): Volume 10 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i10.11471

Abstract

Abstrak: Hubungan Frekuensi Konsumsi Susu Kemasan Dan Status Kebersihan Gigi Dengan Kejadian Karies Gigi Pada Anak Sekolah Dasar  Di Kecamatan Tanjung Senang Bandar Lampung. Karies gigi merupakan penyakit yang menyerang sekitar 90% anak-anak. Menurut Suwelod, karies dipengaruhi oleh faktor eksternal dan internal. Salah satu komponen faktor eksternal adalah perilaku menjaga kesehatan gigi yang diukur dari status kebersihan gigi dan frekuensi konsumsi susu kemasan yang dalam penelitian ini adalah susu kemasan. Mengetahui hubungan frekuensi konsumsi susu kemasan dengan status kebersihan gigi pada anak sekolah dasar di Kecamatan TanjungHappy Bandar Lampung. Jenis penelitian ini adalah kuantitatif analitik dengan desain penelitian cross sectional, alat ukur angket kesabaran dan efikasi diri dengan teknik stratified random sampling. Diperoleh responden sebanyak 100 anak dengan tingkat konsumsi susu kemasan tertinggi pada kategori kecil sebanyak 69 anak (69%), tingkat status kebersihan gigi tertinggi pada kategori baik sebanyak 51 anak (51%), kejadian karies gigi tertinggi dialami karies gigi yaitu sebanyak 72 anak. (71%) Analisis statistik menggunakan uji chi-square pada frekuensi konsumsi susu kemasan dengan kejadian karies gigi dengan nilai p=0,009 dan nilai korelasi OR = 19,286, pada status kebersihan gigi dan kejadian karies gigi. dengan nilai p=0,000 dan nilai korelasi OR = 10,000. Terdapat hubungan yang signifikan antara konsumsi susu kemasan dan status kebersihan gigi dengan kejadian karies pada anak sekolah dasar di Tanjung Senang Bandar Lampung.
Nurse Caring Attitude Relationships with Parents Patient Satisfaction Level in Public Hospitals Pambalah Batung Amuntai Tasalim, Rian; Basit, Mohammad; Agustina, Rita
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 3 No 2: September 2021
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0302.253

Abstract

Caring is a form of nurse's concern for clients. Nurses are required to have the sensitivity and ability to support the trust and well-being of patients. Patient/Parent satisfaction is highly dependent on the caring attitude of the nurse. The better the caring attitude of the nurse to the patient, the more the patient will trust the nurse. Nurse caring behavior is one of the determinants of patient satisfaction. The purpose of this study was to determine the relationship between the caring attitude of nurses and the level of satisfaction of the patient's parents in the pediatric ward of Pambalah Batung Amuntai Hospital. Analytic research with a cross sectional approach. Collecting data using a questionnaire. Respondents in the study amounted to 28 people, using probability sampling technique. Data analysis using Chi-Square. The results show that in the pediatric ward of Pambalah Batung Amuntai Hospital, it is known that the caring attitude of nurses in the classification is not good, namely 68% and the level of satisfaction of parents of patients in the less classification is also as much as 64 % The results of the Chi-Square analysis obtained a significant value of 0.019 (p < 0.05). There is a relationship between the caring attitude of nurses and the level of satisfaction of parents whose children are cared for in the pediatric care room at Pambalah Batung Amuntai Hospital.
Therapeutic Potential of Secretome-Derived Wharton's Jelly Mesenchymal Stem Cells in Psoriasis Vulgaris: A Case Study Azzahara, Salma Yasmine; Agustina, Rita; Prawitasari, Salindri
International Journal of Cell and Biomedical Science Vol 2 No 5 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i5.37

Abstract

Background: Psoriasis is a chronic, immune-mediated skin disease that also has systemic manifestations. Case: In this report, we discuss our findings about a 47-years old psoriasis suffering male patient with a Psoriasis Area Severity Index (PASI) score of 10.8, treated with Wharton’s Jelly Mesenchymal Stem Cells-derived Secretome (S-MSCs). Remarkably, complete regression was recorded within a treatment period of a week only. Result: The patient demonstrated a decrease in PASI, from 10.8 to 3.2 after 1 infusion and followed by 4 intramuscular injections of S-MSCs. Bioactive factors secreted by MSCs, cytokines and growth factors, are very likely to be the principal molecules which play a vital role in inflammatory modulation and skin tissue regeneration. No serious adverse events were noted for the patient as a result of secretome infusion and intramuscular injection. Conclusion: This report demonstrates safety and promises to be an effective strategy using S-MSCs treatment for managing the psoriatic issue and, thus, may offer as an alternative approach to overcome the limitations of the cell-based therapy.
PENGARUH PERCEIVED QUALITY, BRAND AWARENESS, BRAND IMAGE, BRAND TRUST TERHADAP PURCHASE INTETION PRODUK MAKANAN CEPAT SAJI DI INDONESIA Sari, Wulan; Riorini, Sri Vandayuli; Agustina, Rita
JURSIMA Vol 12 No 2 (2025): Volume 12 Nomor 2 2025
Publisher : INSTITUT TEKNOLOGI DAN BISNIS INDOBARU NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47024/js.v13i1.1033

Abstract

This research aims to analyze the influence of Perceived quality, Brand awareness, Brand image, and Brand trust on Purchase intention for fast food products in Indonesia. The research uses quantitative methods by collecting data through questionnaire surveys. The independent variables in this research consist of Perceived Quality, Brand Awareness, Brand Image, and Brand Trust. Meanwhile, the dependent variable in this research is Purchase Intention. This research is included in correlational research. The data used is cross-sectional. Samples will be distributed using purposive sampling to fast food consumers in five big cities in Indonesia. The sample used in this research was 100 respondents. The collected data will be analyzed using Structural Equation Modeling (SEM) with the help of SmartPLS software. The research results show that there is a significant positive influence between Perceived quality, Brand awareness, Brand image and Brand trust on Purchase intention for fast food products in Indonesia.
Anticancer effectiveness of Artemisia annua ethanol extract against MDAMB-231 cancer cells Agustina, Rita; Ari, Psn Masruri Sulistiyanto; Sadikin, Nadya Audina N
International Journal of Cell and Biomedical Science Vol 4 No 10 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i10.68

Abstract

Background: Breast cancer remains one of the leading causes of cancer deaths worldwide, with triple-negative breast cancer (TNBC) posing a significant therapeutic challenge due to its lack of hormonal receptors and resistance to conventional treatment. Artemisia annua L., a medicinal plant traditionally used in Chinese medicine, has received attention for its diverse bioactive compounds, including flavonoids, phenolic acids, and sesquiterpene lactones, which exhibit potential anticancer properties. This study aims to evaluate the in vitro cytotoxic effect of A. annua ethanol extract against MDA-MB-231 human breast cancer cells using the MTT assay. Methods: Extracts were prepared in 10% DMSO and tested at concentrations ranging from 0 to 1000 µg/mL. MDA-MB-231 cells were seeded in 96-well plates and incubated for 24 h before treatment. Post-treatment, cell viability was assessed via MTT assay, and absorbance was measured at 595 nm. The percentage of cytotoxicity was calculated, and the IC₅₀ value was determined through linear regression analysis. Results: The results showed a clear cytotoxic response depending on the dose, with the extract achieving an IC₅₀ value of 56.83 µg·mL-¹ indicating a fairly strong correlation between concentration and cytotoxicity. These findings indicate that A. annua contains bioactive compounds that are able to inhibit cancer cell proliferation. Conclusion: In conclusion, Artemisia annua ethanol extract showed moderate cytotoxic activity against MDA-MB-231 cells, supporting its potential as a complementary therapeutic agent for TNBC. Further studies are needed to elucidate its molecular mechanisms and evaluate its efficacy in vivo.
Harnessing the Innate Effector: A Narrative Review of Advancing Strategies in CAR Engineering, Metabolic Reprogramming, and TME Resistance of Natural Killer Cells for Cancer Immunotherapy Agustina, Rita; Lestari, Endah Agustina; Sidiq, Husni Ahmad; Nazar, M. Ariq
International Journal of Cell and Biomedical Science Vol 4 No 11 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i11.70

Abstract

Natural Killer (NK) cell-based immunotherapy is rapidly emerging as a promising modality for cancer treatment. As pivotal players in the innate immune system, cells independently recognize and eliminate malignant cells without prior sensitization, offering distinct advantages over other cell-based therapies. This review highlights the current landscapes of NK cell adoptive therapy, from fundamental biology to cutting-edge clinical applications. It highlights how advancing NK cell sources, including peripheral blood, umbilical cord blood, established cell lines, and the increasingly significant induced pluripotent stem cells (iPSCs), are driving wider, more standardized therapeutic use. The multifaceted strategies employed to enhance NK cell efficacy are being explored, including advanced expansion protocols and sophisticated genetic engineering techniques such as the introduction of Chimeric Antigen Receptors (CARs) and modifications to bolster antibody-dependent cellular cytotoxicity. Additionally, it also addresses the significant hurdles that remain, primarily the immunosuppressive tumor microenvironment (TME), and discusses innovative strategies being developed to overcome these challenges. By synthesizing preclinical data and results from the latest clinical trials, this review highlights the remarkable progress and bright future of NK cell therapy as a safer, effective, and more accessible cornerstone of cancer treatment.
Co-Authors Ari, Psn Masruri Sulistiyanto Azzahara, Salma Yasmine Fadilla, Mirafzur Haris Festy Ladyani Mustofa Hadi, Dimas Surya Lestari, Endah Agustina Mohammad Basit, Mohammad Nazar, M. Ariq Prawitasari, Salindri Sadikin, Nadya Audina N Sidiq, Husni Ahmad Sjahriani, Tessa Sri Vandayuli Riorini Tasalim, Rian Utami, Deviana Wulan Sari, Wulan