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Pengaruh Pemberian Alkohol Tradisional Ciu Terhadap Kadar Hemoglobin Pada Tikus Putih (Rattus norvegicus) Hilando, Ogik; Widhiyastuti, Endang
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 9 No. 1 (2023): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v9i1.896

Minuman beralkohol menyebabkan prevalensi gangguan kesehatan 0,8% dan ketergantungan alkohol 0,7% dari total 260.581.100 penduduk Indonesia dan menyebabkan kasus keracunan minuman beralkohol sebanyak 768 kasus pada tahun 2019. Minuman beralkohol yang sering dikonsumsi adalah hasil dari fermentasi buah-buahan dengan kandungan etanol didalamnya seperti minuman beralkohol â€œCIUâ€ yang berasal dari fermentasi tetes tebu. Kandungan etanol dalam Ciu akan memberikan efek intosikasi akut dan kronik akibat kadar BAC(Blood Alcohol Concetration) melebihi batas normal(0,08%) dimulai dengan tubuh lemas dan pusing, intoksikasi kronik akan mulai merusak mukosa lambung dan usus halus sehingga menganggu penyerapan nutrisi yang dibutuhkan untuk hematopoesis sehingga sel darah yang terbentuk matur diikuti turunnya kadar hemoglobin. Tujuan penelitian ini untuk mengetahui kadar hemoglobin pada tikus putih (Rattus norvegicus) yang diberi perlakuan minuman beralkohol jenis Ciu. Penelitian ini adalah penelitianÂ quasy experiment/post-test dengan kelompok kontrol dan eksperimen dengan menggunakan teknik sampling simple random sampling, terdapat 4 kelompok yaitu kelompok kontrol, kelompok perlakuan 5 ml Ciu/200 g BB, 10 ml Ciu/200 g BB, dan 15 ml Ciu/200 g BB dengan enam ekor tikus setiap kelompok perlakuan. Pemberian perlakuan dilakukan selama tujuh hari lalu dilakukan pengukuran kadar hemoglobin. Data penelitian dianalisa menggunakan uji ANOVA dengan SPSS statistic 25. Didapatkan hasil ujiÂ One-WayÂ ANOVA dengan nilai sig<0,05dan ujiÂ Post Hoc TukeyÂ pada perlakuan 10 ml dan 15 ml memberikan nilai sig<0,05. Simpulan, terdapat pengaruh terhadap kadar hemoglobin tikus putih (Rattus norvegicus) setelah dilakukan pemberian minuman beralkohol Ciu dosis 10 ml dan 15 ml Ciu/200 g BB.Kata kunci : Hemoglobin, Minuman beralkohol Ciu, Tikus putih (Rattus norvegicus).

Edukasi Bahaya Timbal pada Sekolah Rentan Polusi terhadap Prestasi Akademik dan Kesehatan Siswa Tri Susilowati, Indah; Dewi, Noviana; Widhiyastuti, Endang
Jurnal Surya Masyarakat Vol 5, No 2 (2023): Mei 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.5.2.2023.201-207

This community service project is a promotive and preventive activity that aims to educate students about the danger of lead exposure accumulation in students, delivered to teaching staff throughout Central Java. This activity was conducted as counseling using the webinar method through zoom meetings. Participants were enthusiastic, as seen from the questions asked during the discussion and question-answer sessions. The ability of participants to answer pretest and posttest questions showed an increase in participants’ knowledge between before and after the counseling. The average score of the pretest was 7.00 with a standard deviation of 3.428, while the average score of the posttest was 14.06 with a standard deviation of 1.983. A paired t-test was then used to determine whether the scores from the pretest and posttest differed. Given that the p-value for the difference between the pretest and posttest scores was 0.000, it can be said that the difference is statistically significant. It can be determined that the partner satisfaction questionnaire's answers were valid because they ranged from 0.549 to 0.905 when it was previously assessed for validity using the Pearson product-moment method. The instrument passed the reliability test with a Cronbach Alpha rating of 0.925, indicating that it was trustworthy. According to the results of the partner satisfaction survey, the typical score was 4.09. Thus, it can be concluded that the activity satisfies the participants. Based on the results of data analysis, it can be said that the counseling activities can increase participants’ knowledge about the danger of lead exposure accumulation on students’ achievement.

HUBUNGAN ANTARA ANEMIA DAN PRESTASI BELAJAR DENGAN INDEKS MASSA TUBUH PADA REMAJA PUTRI KELAS VIII DI SURAKARTA Widhiyastuti, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Adolescents aged 13-15 years old were transition from early adolescence to late adolescence which is a period of identity search so easily affected the surrounding environment. Therefore, adolescents at high risk of nutritional disorders because in adolescents experienced increased nutritional needs, the habit of limiting the consumption of food and consumption patterns that often deviate from the rules of nutrition science.Status nutrition and anemia are factors that affect the development of the brain. Brain damage due to nutritional disturbances leads to cognitive impairment, impaired IQ development and impaired learning abilities that subsequently affect learning achievement. Objective: This study aims to determine the correlation between anemia and learning achievement with body mass index (BMI) in adolescent girls of class VIII in Surakarta. Research method: The research design used was observational with cross sectional approach, the population of junior high school girls 3 and SMP Negeri 7 Surakarta even semester of 2015/2016, aged 13-15 years. Research subjects amounted to 120 taken by random sampling. Data obtained through questionnaire, nutritional status measured by z-score. Anemia was measured by Hb levels using cyanmethemoglobin method. Learning achievement is measured from the final exam score. Furthermore, the collected data is processed by using bivariate analysis. Result of research: The value of r = 0,201, odd ratio 4,255 and p = 0,35, this means there was correlation between anemia with body mass indeks (IMT) in junior high school girl of class VIII in Surakarta. While the relation between learning achievement with IMT class of females VIII obtained r = 0.093 with odd ratio = 0,307 and p = 0999. This means there was no relationship between learning achievement and BMI. Conclusion: There is a significant relationship between BMI with anemia No relation between IMT and learning achievement.

Pengaruh Kombinasi Ekstrak Carica Papaya dan Propolis Terhadap Peningkatan Trombosit Widya Ningrum Lobang, Eka; Maharani Putri, Icha; Hanafi, Zidhan; Widhiyastuti, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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to tearing of the skin, causing bleeding. If a person's platelet level <150,000, it’s called thrombocytopenia. Papaya leaves have a content to increase platelets. Propolis can be used as an anti-inflammatory drug because of the presence of CAPE and quertecin which play a role in suppressing T cell activity. CAPE is able to inhibit NF-kB and stimulant IL-2 which stimulates the work of T cells. This study aims to determine whether there is an effect of giving a combination of papaya leaf extract and propolis in increasing platelets. This study used a literature study method where the data used come from research reports, theses or scientific journals both national and international in the last 10 years related to the effect of papaya leaf extract on increasing platelets. Previous research has shown there is an effect of papaya leaf extract on the increase in platelet count (p 0.00004). Previous research has also mentioned that propolis contains a variety of components, such as flavonoids and alkaloids. Flavonoids in propolis are able to support the performance of papaya leaf extract in increasing the number of platelets. The conclusion in this study was that the papaya leaf extract was effective enough to help increase the platelet count. The combination of papaya leaf extract and propolis extract can help reduce inflammation.

HUBUNGAN ANTAR USIA KEHAMILAN DENGAN JUMLAH LEUKOSIT PADA IBU HAMIL DI PUSKESMAS SLAHUNG PONOROGO Suryani, Eka; Widhiyastuti, Endang
Jurnal Analis Laboratorium Medik Vol 7 No 1 (2022): Jurnal Analis Laboratorium Medik
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jalm.v7i1.2229

Leukocytes are blood cells that play a role in the immune mechanism. Leukocytes are classified based on the presence or absence of granules in the cytoplasm of leukocytes, which consist of granulocytes and agranulocytes. The normal leukocyte count is 3200-10000/mm3 of blood. If the leukocytes are above the normal limit, it is called leukocytosis. Leukocytosis can be pathological or physiological. Physiological leukocytosis that occurs during pregnancy is common due to two reasons, namely a physiological stress and an increased inflammatory response. Physiological stress arises as a response to changes that occur in the body of pregnant women, including the workload of the heart, digestive system, metabolism, thereby stimulating the production of white blood cells to increase immunity. The inflammatory response is a form of the body's selective immune tolerance, immunosuppression and immunomodulation of the fetus. The purpose of this study was to determine the relationship between gestational age and leukocyte count in pregnant women at the Slahung Health Center, Ponorogo Regency, which was conducted in July 2021. This study uses an analytical observational analytic method with a cross sectional approach. This research was conducted by examining gestational age and leukocyte count in pregnant women with a total sample of 30 samples and using a total sampling technique. Examination of the number of leukocytes using the Hematology Analyzer URIT 3000 Plus. The results based on the average number of leukocytes from this study in the first trimester were 3.20 x103/mm3, in the second trimester 8.42 x103/mm3, and in the third trimester 12.56 x103/mm3. The results of test using the Kruskal-Walis obtained a significance value of 0.000 < 0.05. The results of this study can be concluded that there is a relationship between gestational age and the number of leukocytes in pregnant women

The Urgency of Genetic Research in Humans Trikusumaadi, Stefanus Khrismasagung; Dewi, Noviana; Widhiyastuti, Endang
Indonesian Journal of Global Health Research Vol 6 No 4 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i4.3236

Genetic research is a breakthrough in the field of molecular biology which has been proven to contribute to health both in diagnosis and therapy. To support the achievement of these competencies, health students need to view the importance of genetic studies in humans. A person's understanding of a subject is greatly influenced by a person's cognition and the information they absorb. Using a survey approach to students and stakeholders of health science universities. The aim of this study to obtain an overview of health students' understanding of the urgency of genetic research in humans. The level of student understanding of the meaning of genetics is considered quite good with an average score of 2.10 on a scale of 0 – 3. Based on the assessment of various genetic research titles, students' understanding of the urgency of genetic research in humans is relatively high, with an average score of 3.19 on a scale of 1-4. There were no differences in student assessments regarding the urgency of genetic research in humans in each class. Significant differences based on generation appear in students' preferences for research on human genetics.

Evaluation of Blood Mercury Levels and Creatinin Levels in Indonesian Traditional Gold Miners in Central Java Wimpy, Wimpy; Widhiyastuti, Endang; Puspitasari, Lala
Indonesian Journal of Global Health Research Vol 6 No 4 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i4.3519

Based on the world gold council data in 2024, Indonesia is the eighth largest gold producing country in the world. More than 200 gold mining locations spread throughout Indonesia, but gold mining processes in Indonesia especially in Central Java are still carried out traditionally. The importance of this research is that traditional gold mining can lead to health issues such as mercury poisoning and impaired kidney function wich is characterized by the increased of creatinine levels Purpose : to evaluate the blood mercury levels and creatinine levels in Indonesian traditional gold miners in Central Java. Methods : This research uses a cross-sectional analitycal method. The number of samples in this research was 20 gold miners as respondents using a quota sampling technique. Data on blood mercury level results were obtained by examining blood mercury levels with a mercury analyzer and creatinine levels were obtained by examining serum creatinine with a photometer. The spearman’s rho test is used to test the correlation between blood mercury and creatinine levels. Results : As many as 19 out of 20 respondents had mercury levels of more than 20 µg/L, exceeding the threshold set by NCBI but they all had creatinine levels that were still within normal limits according to the NCBI limits wich is less than 1,2 mg/dL. The results of the Pearson correlation test obtained a sig. value (2 tailed) 0,962 where it can be concluded that there is no correlation between blood mercury levels and creatinine levels in.

Discourse on Human Genetics Research in Mass Media News Trikusumaadi, Stefanus Khrismasagung; Dewi, Noviana; Widhiyastuti, Endang
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5606

The development of genetic research in humans provides new hope for a better quality of life. One of the studies can reveal the molecular mechanism of a disease, the direction of prevention, and its treatment. Online and offline newspapers are one alternative publication for a wider audience. The purpose of this research is to see how the results of genetic research in humans are constructed in media discourse, both in the form of news, features, and news articles. The ideological content will be explored through an analysis of rhetorical elements in news discourse. This research is a qualitative content analysis, using the discourse analysis method. The unit of analysis is news texts about human genetic research published in 5 online newspapers with the highest readers in the period January - December 2024. Reduction was carried out to obtain relevant news samples. The research results show that the results of human genetic research are discussed in health and lifestyle themes with informative and advocative purposes. The news conveys the latest research results, while also providing recommendations for healthy living at the individual level without a complete explanation in a broader social context. Based on the analysis of rhetorical elements, such presentation indicates the existence of a certain ideology at play in the construction of discourse.

Pengaruh Pemberian Alkohol Tradisional Ciu Terhadap Kadar Hemoglobin Pada Tikus Putih (Rattus norvegicus) Hilando, Ogik; Widhiyastuti, Endang
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 9 No. 1 (2023): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v9i1.896

Minuman beralkohol menyebabkan prevalensi gangguan kesehatan 0,8% dan ketergantungan alkohol 0,7% dari total 260.581.100 penduduk Indonesia dan menyebabkan kasus keracunan minuman beralkohol sebanyak 768 kasus pada tahun 2019. Minuman beralkohol yang sering dikonsumsi adalah hasil dari fermentasi buah-buahan dengan kandungan etanol didalamnya seperti minuman beralkohol â€œCIUâ€ yang berasal dari fermentasi tetes tebu. Kandungan etanol dalam Ciu akan memberikan efek intosikasi akut dan kronik akibat kadar BAC(Blood Alcohol Concetration) melebihi batas normal(0,08%) dimulai dengan tubuh lemas dan pusing, intoksikasi kronik akan mulai merusak mukosa lambung dan usus halus sehingga menganggu penyerapan nutrisi yang dibutuhkan untuk hematopoesis sehingga sel darah yang terbentuk matur diikuti turunnya kadar hemoglobin. Tujuan penelitian ini untuk mengetahui kadar hemoglobin pada tikus putih (Rattus norvegicus) yang diberi perlakuan minuman beralkohol jenis Ciu. Penelitian ini adalah penelitianÂ quasy experiment/post-test dengan kelompok kontrol dan eksperimen dengan menggunakan teknik sampling simple random sampling, terdapat 4 kelompok yaitu kelompok kontrol, kelompok perlakuan 5 ml Ciu/200 g BB, 10 ml Ciu/200 g BB, dan 15 ml Ciu/200 g BB dengan enam ekor tikus setiap kelompok perlakuan. Pemberian perlakuan dilakukan selama tujuh hari lalu dilakukan pengukuran kadar hemoglobin. Data penelitian dianalisa menggunakan uji ANOVA dengan SPSS statistic 25. Didapatkan hasil ujiÂ One-WayÂ ANOVA dengan nilai sig<0,05dan ujiÂ Post Hoc TukeyÂ pada perlakuan 10 ml dan 15 ml memberikan nilai sig<0,05. Simpulan, terdapat pengaruh terhadap kadar hemoglobin tikus putih (Rattus norvegicus) setelah dilakukan pemberian minuman beralkohol Ciu dosis 10 ml dan 15 ml Ciu/200 g BB.Kata kunci : Hemoglobin, Minuman beralkohol Ciu, Tikus putih (Rattus norvegicus).

PEMELIHARAAN KESEHATAN PADA KASUS HIPERTENSI DENGAN PEMANFAATAN DAUN KELOR DAN DUKUNGAN KOMUNIKASI KELUARGA Trikusumaadi, Stefanus Khrismasagung; Widhiyastuti, Endang
Bengawan : Jurnal Pengabdian Masyarakat Vol 2 No 1 (2022): Juni
Publisher : Politeknik Indonusa Surakarta

Abstrak: Hipertensi menjadi salah satu penyakit tidak menular yang menjadi prioritas dalam dunia kesehatan secara global. Kasus di Indonesia, ditemukan bahwa adalah 59,8% penderita hipertensi merasa sudah sehat. Dari angka tersebut, hanya 54,4% yang minum obat secara rutin, dan 14,5% minum obat tradisional. Untuk itu pengabdian ini bertujuan meningkatkan pengetahuan peserta tentang hipertensi, penanganan hipertensi secara non farmakologis dengan memanfaatkan daun kelor, dan fungsi keluarga dalam mendukung pemeliharaan kesehatan pada kasus hipertensi. Dengan metode pendidikan kesehatan, penyuluhan dilakukan terhadap 26 warga Dusun Tembolan, Mancasan, Baki Sukoharjo. Setelah memperoleh pemaparan materi, terjadi peningkatan pengetahuan pada 75% peserta terkait dengan hipertensi, manfaat daun kelor untuk menurunkan tekanan darah, serta dukungan komunikasi keluarga terhadap pemeliharan kesehatan pada kasus hipertensi, Nilai- nilai penting yang didapatkan adalah bahwa terapi terhadap hipertensi bukan hanya dengan pendekatan farmakologis, namun juga non farmakologis, Pemanfaatan daun kelor dapat mendukung terapi obat bagi pasien hipertensi. Lebih dari itu Dukungan keluarga, dalam suatu iklim komunikasi yang kondusif sangat deperlukan untuk efektivitas perawatan. Kata Kunci : Daun Kelor, Hipertensi, Komunikasi Keluarga Abstract: Hypertension is one of the non-communicable diseases that is a priority in the world of global health. In Indonesia, it was found that 59.8% of hypertensive patients felt they were healthy. Of this figure, only 54.4% take medicine regularly, and 14.5% take traditional medicine. For this reason, this Community service aims to increase participants' knowledge about hypertension, non-pharmacological hypertension management by utilizing Moringa leaves, and family functions in supporting health care in cases of hypertension. Using the health education method, counseling was carried out to 26 residents of Dusun Tembolan, Mancasan, Baki Sukoharjo. After receiving the material exposure, there was an increase in knowledge in 75% of participants related to hypertension, the benefits of Moringa leaves for lowering blood pressure, as well as family communication support for health maintenance in cases of hypertension. pharmacological, but also non-pharmacological, the use of Moringa leaves can support drug therapy for hypertensive patients. More than that, family support, in a conducive communication climate, is very necessary for the effectiveness of treatment. Keywords: Moringa leaves, hypertension, Family Communication

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