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All Journal The Indonesian Biomedical Journal JIK- JURNAL ILMU KESEHATAN
Handini, Haspita Rizki Syurya
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Biochemistry, Genetics & Molecular Biology Health Professions Nursing Public Health

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Pengaruh Abdominal Stretching Exercise Terhadap Penurunan Intensitas Nyeri Haid Pada Remaja Putri Faridah, Faridah; Handini, Haspita Rizki Syurya; Dita, Revina
JIK-JURNAL ILMU KESEHATAN Vol 3, No 2 (2019): JIK-Oktober Volume 3 No 2 Tahun 2019
Publisher : UNIVERSITAS ALIFAH PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.34 KB) | DOI: 10.33757/jik.v3i2.207

Abstract

Di Indonesia, lebih dari 55% perempuan mengalami dismenore dan angka kejadian di Sumatera Barat mencapai 57,3%. Dismenore mengakibatkan 10% remaja putri kesulitan dalam beraktivitas, seperti tidak konsentrasi dalam belajar atau bahkan tidak hadir di sekolah. Abdominal stretching exercise merupakan terapi alternatif yang dapat digunakan untuk menurunkan intensitas nyeri haid pada remaja putri di SMPN 1 Sungai Beremas Kabupaten Pasaman Barat Tahun 2019. Jenis penelitian ini adalah preexperiment design dengan pendekatan one group pretest posttest design dan dari populasi sebanyak 84 remaja putri yang nyeri haid didapat sampel sebanyak 16 orang secara purposive sampling. Penelitian dilakukan dari bulan Oktober 2018 sampai Juni 2019. Data dikumpulkan dengan cara mengukur intensitas nyeri menggunakan numeric rating scale. Analisis data terdiri dari univariat dan bivariat menggunakan komputerisasi dengan uji t dependen. Hasil penelitian didapatkan rata-rata nyeri haid sebelum dan sesudah dilakukan abdominal stretching exercise adalah 4,88 dan 2,69. Selain itu, hasil penelitian ini menunjukkan bahwa ada pengaruh abdominal stretching exercise terhadap penurunan intensitas nyeri haid dengan p value = 0,000.Berdasarkan hasil analisis diatas, dapat disimpulkan bahwa abdominal stretching exercise efektif dalam menurunkan intensitas nyeri haid.Kata kunci : Dismenore, nyeri haid, abdominal stretching exercise
Nanocurcumin Enhances Antioxidant Defense through GPx Upregulation in Ovarian Granulosa Cells of Endometriosis Mouse Model Handini, Haspita Rizki Syurya; Hendarto, Hendy; Purwanto, Bambang; Widjiati, Widjiati
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3846

Abstract

BACKGROUND: Endometriosis impairs female reproductive function through oxidative stress and apoptosis, reducing oocyte quality and causing infertility. Current therapies are limited by suboptimal efficacy and side effects, including ovulation suppression. Curcumin offers antioxidant and anti-inflammatory benefits but has low bioavailability and poor solubility, which can be improved through nanoparticle formulation. Although nanocurcumin is suggested to act through multiple pathways, its mechanisms remain unclear. This study was conducted to evaluate the antioxidant and anti-apoptotic effects of nanocurcumin in a mouse model of endometriosis.METHODS: Thirty-five mice were allocated into five groups and induced to develop endometriosis using cyclosporine A, ethinyl estradiol, and human endometrial tissue. Nanocurcumin was formulated at three particle sizes (3.71; 3.98; and 25.60 nm) and administered orally at doses of 50, 100, or 200 mg/kg/day for 14 days. After treatment, the mice were euthanized, and ovarian tissues were collected for immunohistochemical analysis of glutathione peroxidase (GPx) and B-cell lymphoma-2 (Bcl-2) expression.RESULTS: The highest GPx expression was observed in the group receiving 50 mg/kg/day nanocurcumin (mean±SD= 6.31±1.97; p=0.042). The lowest expression of Bcl-2 was observed in control group with no treatment (mean±SD=4.15±2.48; p=0.582). Nanocurcumin administration significantly increased GPx expression in a dose-dependent manner compared with the untreated group, while no significant differences were found in Bcl-2 expression.CONCLUSION: Nanocurcumin increases GPx expression, particularly at 50 mg/kg/day, indicating its potential as an antioxidant in reducing oxidative damage associated with endometriosis. However, nanocurcumin did not significantly influence Bcl-2 expression. These findings support nanocurcumin’s role as an effective antioxidant agent in protecting ovarian granulosa cells in endometriosis.KEYWORDS: nanocurcumin, GPx, Bcl-2, endometriosis, granulosa cells
Co-Authors Bambang Purwanto Dita, Revina Faridah Faridah Hendy Hendarto Widjiati Widjiati, Widjiati