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Wardani, Diah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology

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Studi Literatur Pemanfaatan Tanaman Suku Zingiberceae sebagai Antidepresan Afifah, Aminia; Kurniadi, Dede; Nurul; Wardani, Diah
Jurnal Medika Farmaka Vol 1 No 2 (2023): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v1i2.8

Abstract

Introduction: Depression is a mental disorder characterized by persistent depressed feelings that can affect mood, behavior and physical health. Based on basic health research data in 2018, the total number of cases affected by depression in Indonesia at the age of more than 15 years reached 6.1%. Depression therapy generally uses antidepressant drugs. The side effects of antidepressant drugs are not light, therefore it is necessary to explore plant-based medicine to treat mental disorders. Therefore, to avoid the side effects caused by these antidepressant drugs, alternative medicine from plants can be used. One of the plants that have the potential as an antidepressant is from the Zingiberaceae family. Method: The method used in writing is by conducting a literature study related to plants of the Zingiberaceae family which have the potential to have antidepressant activity contained in national and international journals published in the last 10 years. Result: Based on the results of literature research, there are several plants that have potential as antidepressants, there are 5 plants from the Zingiberaceae family, including Turmeric (Curcuma longa L), Temulawak (Curcuma xanthoriza), Temugiring (Curcuma heyneana), Black turmeric (Curcuma caseia) and the last namely Ginger (Zingiber officinale Rosc). Plants that have the greatest antidepressant activity are Curcuma heyneana plants with doses of 100 and 200 mg/kg. Conclusion. With the preparation of this paper, it is hoped that it can provide scientific information about plants that have the potential as antidepressants derived from plants of the Zingiberaceae family which can be used as an alternative treatment for depression mental illness.
Formulasi dan Evaluasi Fisik Sediaan Salep Dari Ektrak Bonggol Pisang Kepok (Musa paradisiaca L) Mubarok, Azis Zamzam; Wahyuni, Nency; Wardani, Diah
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.35

Abstract

Wounds are a condition that is often experienced by everyone, whether with mild, moderate or severe severity, injury is the loss or destruction of body tissue. The wound healing process occurs in damaged tissue which is divided into three phases, namely the inflammatory phase, the proliferative phase and the maturation phase, which is tissue remodeling. Research on kepok bananas shows that banana weevil extract has higher antimicrobial activity than its midrib extract. In addition to accelerating wound healing, banana weevil can help repair damaged skin structures without scars and increase the revitalization of epidermal tissue, formation of fibroblasts and infiltration of inflammatory cells in the wound area. can be developed into cosmetics. this is the reason for making an ointment containing banana weevil extract with formulation 1 containing 1 g ethanol, formulation 2 containing 1.5 g ethanol, and formulation 3 containing 2 g ethanol. By evaluating the preparations to determine the physical stability of the preparations made including organoleptic testing, homogeneity testing, pH testing, testing the dispersion of the preparation and testing the organoleptic stability of the preparation, the pH stability of the preparation. The results showed that in the organoleptic test only 2 formulations met the quality standards, in the homogeneity test there were 2 formulations that met the criteria, in the pH test all formulations met the quality standards, in the dispersion test all formulations met the criteria, and in the stability test there were differences in storage. under exposure to sunlight but there is no change in the stability of the pH of the preparation made. Based on the research that has been done, it can be concluded that all formulations and physical evaluations of ointment preparations from the Kepok Banana Weevil Extract (Musa paradisiaca L). with variations of kepok banana weevil extract at F1 (15%), F2 (20%), and F3 (25%) met the requirements of good organoleptic, pH (4-7), and viscosity (2000-5000 mPas) tests.
Pengaruh Infusa Jahe Merah (Zingiber officinale var. Rubrum) terhadap Pertumbuhan Bakteri Streptococcus mutans Nugraha, Yogi Rahman; Rohdiana, Aulia; Nurul; Wardani, Diah
Jurnal Medika Farmaka Vol 2 No 3 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i3.74

Abstract

Oral infections remain a significant public health problem in Indonesia, with dental caries being highly prevalent and primarily associated with Streptococcus mutans. The use of modern antibiotics for caries treatment often leads to side effects and bacterial resistance, prompting the search for herbal-based alternatives. Red ginger (Zingiber officinale var. rubrum) contains bioactive compounds such as flavonoids, phenols, gingerol, shogaol, and essential oils, which are known for their antibacterial activity. This study aimed to evaluate the inhibitory effect of red ginger infusion on the growth of S. mutans. A Posttest Control Group design was employed, and antibacterial activity was assessed using the disk diffusion method. Treatments consisted of a negative control (distilled water), a positive control (ciprofloxacin 5 µg), and red ginger infusion (RGI) at concentrations of 10%, 20%, and 40%. Results demonstrated an increase in inhibition zone diameter with higher concentrations of RGI. The negative control produced no inhibition, while the positive control showed the largest inhibition zone (45.05 mm). RGI at 10% yielded 7.91 mm (p=0.408), 20% yielded 14.81 mm (p=0.066), and 40% yielded 23.05 mm (p=0.022). Only the 40% concentration showed a statistically significant difference compared to the negative control (p<0.05). These findings indicate that red ginger infusion possesses antibacterial activity against S. mutans, although its effectiveness is still below that of ciprofloxacin. Therefore, red ginger may be considered as a potential herbal alternative for dental caries prevention, particularly as a supportive therapy. Further studies are required to isolate active compounds and develop more effective topical formulations.
Formulasi dan Evaluasi Sifat Fisik Serum Daun Sirih Hijau (Piper betle L.) dengan Kombinasi Kolagen Sisik Ikan Gurami (Osphronmus goramy Lac.) sebagai Penghambat Bakteri Acne Vulgaris Wardani, Diah; Fauzan Nul Hak, Moch; Nurul
Jurnal Medika Farmaka Vol 3 No 2 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i2.75

Abstract

Acne vulgaris is a chronic skin disorder characterized by inflammation due to excessive sebum production and abnormal follicular desquamation. Natural ingredients are considered as promising alternatives, such as green betel leaf (Piper betle L.) containing phenols, flavonoids, and tannins with antibacterial and anti-inflammatory activity. Meanwhile, gourami fish scales (Osphronemus gouramy Lac.) are a source of type I collagen with a triple-helix structure that has potential as an anti-aging agent. This study aimed to formulate and evaluate a serum combining green betel leaf extract and gourami fish scale collagen as an inhibitor of acne vulgaris bacteria. An experimental laboratory study was conducted using three formulas with different concentrations of active ingredients. Physical evaluations included organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesion on days 7, 14, 21, and 28, along with antibacterial effectiveness testing. The results showed that the best formula was 20% green betel leaf extract combined with 5% collagen, with 83.33% stability parameters fulfilled. The serum produced an inhibition zone of 29.88 mm against acne vulgaris bacteria, although viscosity did not meet the standard range (230–3000 cPs). Thus, this combination has potential as an effective natural anti-acne serum but requires viscosity optimization.
Co-Authors Afifah, Aminia Fauzan Nul Hak, Moch Jayawarsa, A.A. Ketut Mubarok, Azis Zamzam Nurul Rohdiana, Aulia Wahyuni, Nency Yogi Rahman Nugraha