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All Journal Indonesian Food Science and TechnologyJournal
Dewi, Fitriya N.
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Agriculture, Biological Sciences & Forestry

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Torbangun (Plectranthus amboinicus (Lour.) Spreng) Leaf Extract Upregulates Expression of Lactation-Related Genes in Human Mammary Epithelial Cells MCF-12A Tafzi, Fitry; Andarwulan, Nuri; Giriwono, Puspo Edi; Dewi, Fitriya N.
Indonesian Food Science and Technology Journal Vol. 8 No. 1 (2024): Volume 8. Number 1, December 2024 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i1.37364

Abstract

Torbangun (Plectranthus amboinicus (Lour). Spreng) leaf is a herbaceous plant capable of increasing breast milk, although the mechanism of bioactive compounds on the molecular level remains relatively unknown. Therefore, this study aimed to evaluate the effect of torbangun leaf extract on the expression of genes associated with alveologenesis and the formation of milk protein, namely prolactin receptor (PRLR), glucocorticoid receptor (GR), signal transducer, as well as activator of transcription 5A (STAT5A) and b-casein (CSN2). The result showed that the extract and fractions of torbangunleaf had IC50 values above 20 ug/ml against MCF-12A cells. Ethyl acetate fraction also enhanced the expression of gene GR, STAT5A, and CSN2. Water fraction of torbangun leaf enhanced expression of gene PRLR, GR, STAT5A, and CSN2. The bioactive compound was found to increase the expression of genes associated with proliferation, alveologenesis, and the formation of milk protein during gestation and lactation.
Co-Authors FITRY TAFZI Nuri Andarwulan Puspo Edi Giriwono