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All Journal Global Medical and Health Communication Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Penelitian Pendidikan IPA (JPPIPA)
Margiana, Ria
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Effect of Umbilical Cord-derived Mesenchymal Stem Cell Secretome on Corpus Cavernosum Elastography Results in Patients with Severe Erectile Dysfunction Non-responsive to Sildenafil Pratama, Andi Ahmad Thoriq; Rahardjo, Paulus; Atmaja, M Hidayat Surya; Supardi, Petrus; Margiana, Ria
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14144

Abstract

Erectile dysfunction is one of the most common male sexual dysfunctions, defined as the inability to get or maintain an erection, and its prevalence is increasing over time. The current treatment, using a phosphodiesterase-5 inhibitor like sildenafil, only offers a temporary solution. Secretome, a bioactive substance derived from mesenchymal stem cells from the umbilical cord, has shown remarkable regenerative capabilities. This study aims to explore the potential of administering umbilical cord-derived mesenchymal stem cell secretome to patients with severe erectile dysfunction and evaluate its impact on the stiffness of the corpus cavernosum using elastography in the flaccid phase. This study employed a pre-experimental design with a pre-post test. It involved seven patients who came to Dr. Soetomo Hospital with severe erectile dysfunction that was unresponsive to sildenafil. Elastography evaluation, including strain and shear wave elastography, was performed before and one month after secretome injection, which was carried out from March to April 2024. Data were analyzed using the paired sample t-test when the data distribution was normal and the Wilcoxon test when the data distribution was not normal. There were statistically significant changes (p<0.05) in all patients who underwent strain and shear wave elastography of the corpus cavernosum before and one month after secretome administration, indicating an improvement in stiffness. In conclusion, intracavernosal administration of umbilical cord-derived mesenchymal stem cell secretome has demonstrated promising results in treating severe erectile dysfunction non-responsive to sildenafil therapy. These results include improved penile tissue in the corpus cavernosum, as evidenced by decreased stiffness on elastography.
Evaluating the effectiveness of Thiel embalming solution for preserving cadavers in anatomy and surgical education Indrawan, I Made Rayo Putra; Margiana, Ria
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.21946

Abstract

Cadavers have played a crucial role in anatomy teaching, owing to their resemblance to the anatomical structures found in living individuals. To optimize the utilization of cadavers, embalming procedures that involve the application of chemical fixative agents are needed. The "soft embalming" approach, which involves various salts as fixating agents, was first developed by Walter Thiel. Although the Thiel solution has demonstrated efficacy in enhancing tissue elasticity, consistency, and color, a study is needed to find the most suitable for embalming with this solution to maximize its utility in the context of anatomy and surgical education. The study results show that the Thiel solution produces the best outcomes for its flexibility, uniformity, and color, which is optimal for anatomical and surgical teaching. The efficacy of Thiel's solution for preserving cadavers for educational intentions is noteworthy for the study of anatomy and surgical procedures. The advantageous characteristics of Thiel embalming include flexibility, consistency, and natural coloring. Nevertheless, it is crucial to consider the restrictions associated with preserving the brain, spinal cord, eye, and musculoskeletal tissues. In conclusion, the utilization of Thiel solution has proven to be an efficient embalming agent for preserving cadavers in the fields of anatomy and surgery education, besides brain, spinal cord, eye, and musculoskeletal systems, should be reconsidered.
The Success Rate of Cryopreservation and Thawing of Embryos at Day 3 and Day 5 Following Intracytoplasmic Sperm Injection (ICSI) Margiana, Ria; Wen, Maitra Djiang
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9327

Abstract

Cryopreservation, the technique of freezing and thawing embryos, is essential in in vitro fertilization (IVF) treatments to ensure the long-term preservation of embryos for future use. This innovative study evaluates the effectiveness of these procedures conducted at a private hospital in Tangerang, Indonesia, over a period of seven years (2016-2023), involving 18,000 couples. The design research was conducted retrospectively. The study examined embryos that underwent cryopreservation and subsequent thawing, with data collected on the rates of cell division observed on Day 3 and the rates of blastocyst formation on Day 5 after thawing. The study investigated the rates of cellular division on Day 3 and the development of blastocysts on Day 5 following the thawing process. The findings demonstrated a remarkable cleavage rate of 95.24% and a blastocyst rate of 97.22%. The remarkable results underscore the efficacy of the advanced freezing and thawing techniques employed. This discovery is highly significant since there is an urgent requirement to improve the success rates of in vitro fertilization (IVF) for couples facing infertility. It offers a fresh sense of hope and increased opportunities for establishing successful pregnancies with the improvement of cryopreservation techniques.
Co-Authors Atmaja, M Hidayat Surya Indrawan, I Made Rayo Putra Paulus Rahardjo, Paulus Pratama, Andi Ahmad Thoriq Supardi, Petrus Wen, Maitra Djiang