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All Journal E-Jurnal Medika Udayana Journal of General-Procedural Dermatology & Venereology Indonesia
Praharsini, IGAA
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Health Professions Medicine & Pharmacology

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Elevated homeostatic model assessment of insulin resistance level increases the risk of acne Nurhadi, Stefani; Praharsini, IGAA; Wiraguna, AAGP
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Insulin resistance and high carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes duct and the production of sebum in acne of the pilosebaceous. Methods: This is a cross sectional observational analytic study involving 38 acne patients and 38 controls. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is a risk factor for acne. HOMA-IR formula was used to determine insulin activity in basal state. High HOMA-IR values are expressed from cut-off point ≥2. Subject was recruited with consecutive sampling who meets inclusion and exclusion criteria. Fasting insulin and blood glucose levels was derived from venous blood examination. Results: The average age of acne subjects was 23.71 years old in both groups (10 men and 28 women). The mean value of HOMA-IR in the acne group was higher (2.63 ± 0.29) than those in the control group (1.71 ± 0.26) and was statistically significant difference (p value <0.001). The prevalence ratio was 31.58, meaning that patients with high HOMA-IR were 31.6 times more likely to have acne than patients with normal HOMA- IR values. These results were statistically significant (p <0.001). Conclusion: Elevated HOMA-IR is one of the factors which increase the risk of acne development in an individual.
PROFIL PASIEN AKNE VULGARIS DI POLIKLINIK DERMATOLOGI DAN VENEREOLOGI RUMAH SAKIT UMUM PUSAT PROF. DR. I.G.N.G NGOERAH DENPASAR, BALI PERIODE TAHUN 2019-2021 primasari, yunita; Praharsini, IGAA
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P02

Abstract

Pendahuluan: Akne vulgaris adalah penyakit peradangan kronik dari unit pilosebasea yang ditandai dengan komedo, papul, pustul, nodus dan kista. Akne vulgaris dapat menimbulkan permasalahan fisik dan psikososial sehingga hasil penelitian ini diharapkan dapat berimplikasi pada tatalaksana dan peningkatan kualitas hidup penderita akne vulgaris. Tujuan: Mengetahui prevalensi, sosiodemografi, derajat akne vulgaris dan tatalaksananya di Poliklinik Dermatologi dan Venereologi RSUP Prof. Dr. I.G.N.G Ngoerah selama Januari 2019 hingga Desember 2021. Metode: Rancangan penelitian deksriptif retrospektif dengan menggunakan data sekunder pada rekam medis. Hasil: Jumlah pasien berkunjung ke poliklinik sebanyak 15.616 pasien. Sebesar 1.87% pasien baru dengan diagnosis akne vulgaris dengan prevalensi 78.43% perempuan, 65.41% usia 10-30 tahun dan 82.87% pasien dengan derajat keparahan ringan. Berdasarkan tatalaksana, 100% pasien mendapat medikamentosa dan 64.38% pasien mendapat prosedur tindakan. Berdasarkan medikamentosa, 100% pasien mendapat tabir surya, disertai asam retinoat 46.57%, benzoil peroksida 2.05%, antibiotik topikal 2.05%, kombinasi asam retinoat dan benzoil peroksida 18.83%, kombinasi asam retinoat dan antibiotik topikal 15.41%, kombinasi asam retinoat, benzoil peroksida dan antibiotik topikal 15.06% dan antibiotik oral 16.78%. Berdasarkan prosedur tindakan, 53.42% pasien mendapat peeling kimia superfisial, 2.40% pasien mendapat injeksi kortikosteroid intralesi dan 8.56% pasien mendapat terapi berbasis cahaya. Kesimpulan: Prevalensi akne vulgaris sebesar 1,87%, sebagian besar terjadi pada perempuan, usia 10-30 tahun dengan derajat keparahan ringan. Tatalaksana yang diberikan meliputi terapi medikamentosa dan prosedur tindakan yang sudah sesuai dengan guideline tatalaksana akne vulgaris berdasarkan Indonesian Acne Expert Meeting (IAEM) 2015. Kata kunci: akne vulgaris, medikamentosa, tindakan
Co-Authors primasari, yunita Stefani Nurhadi Wiraguna, AAGP