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Vitiligo Fokal pada Anak Yang Diterapi dengan Target Excimer Light 308 nm Nurhadi, Stefani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 2 (2019): EDISI SEPTEMBER 2019 (available online since Oktober 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Vitiligo is a acquired skin disease characterized by a well-defined depigmented macules caused by progressive loss of functional melanocytes. Vitiligo usually appears first during childhood or young adults. Management of vitiligo in children are more difficult because the preference of therapy is limited when compared with adult. Targeted 308 nm UVB phototherapy is used for local vitiligo in children as it can be focused on the lesion and reduce the side effects. A 4-year-old girl, came to dermato-venereology polyclinic of Indera Hospital Denpasar with complaints of white patch on her lips for 3 weeks. Based on the history and physical examination, she was diagnosed with focal vitiligo. She was treated with targeted 308 nm excimer light phototherapy three times a week. Five sessions of phototeraphy resulted good response characterized by repigmentation of the lesion without redness and blisters.The therapy aims to achieve the best results with minimal side effects. Phototherapy targets are recommended for local vitiligo and especially for new small lesions as well as pediatric vitiligo. The mechanisms of this phototherapy is to trigger repigmentation, stabilization, immunosuppression and immunomodulation. The conclusion is targeted 308 nm phototherapy is quite useful for treating vitiligo even though more therapy sessions are needed.

The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris Praharsini, I Gusti Ayu Agung; Wiraguna, Anak Agung Gde Putra; Nurhadi, Stefani
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 Ã‚Â± 0.29 meanwhile in the control group was 1.71 Ã‚Â± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.

Elevated homeostatic model assessment of insulin resistance level increases the risk of acne Stefani Nurhadi; IGAA Praharsini; A. A. Gde Putra Wiraguna
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 1 (2018): December 2018
Publisher : Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Insulin resistance and carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes of the pilosebaceous duct and the production of sebum in acne. This is a cross sectional observational analytic study involving 38 acne patient and 38 non acne patients. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is a risk factor for acne. HOMA-IR formula was used to determine insulin activity in basal state. High HOMA-IR values are expressed from cut-off point ≥2. Sampling by consecutive sampling that meets inclusion and exclusion criteria. Fasting insulin and glucose levels is derived from venous blood examination. The average age of acne subjects was 23.71 years (10 men and 28 women). The mean value of HOMA-IR in the acne group was higher (2.63 ± 0.29) than those in the non acne group (1.71 ± 0.26) and statistically significant (p value <0.001). The prevalence ratio was 31.58, meaning that patients with high HOMA-IR were 31.6 times more likely to have acne than patients with normal HOMA-IR values. These results were statistically significant with p value <0.001. The conclusion was elevated HOMA-IR is one of the factors that increase the risk of someone developing acne.

The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Stefani Nurhadi
Bali Dermatology and Venereology Journal Vol. 1 No. 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v1i2.8

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 Â± 0.29 meanwhile in the control group was 1.71 Â± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.

LITERATURE REVIEW: Effectiveness of Chatbot to Reduce the Risk of Coronary Heart Disease using Android-based application Agnes Atmadjaja; Minarni Watinin; Stefani Nurhadi
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 3 (2022): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i3.4094

Background: An innovative approach in the form of a discussion platform designed to help users deal with health issues related to coronary artery disease. Chatbot platforms allow the collection of users' data, which is analyzed through natural language processing and behavioral analysis, to provide each user with a customized solution based on their current situation. The data collected and analyzed is accessible. The platform is developed using chatbot technology. Users can interact with chatbots to generate personal chat data stored on the platform. Conflicting information and sensitivity to Coronary Heart Disease (CHD) issues hinder effective communication. Recent technological solutions to maintain weight loss are limited. A chatbot would be suitable to support weight loss as it requires no human intervention, is available 24 hours a day, and supports natural communication while maintaining anonymity. The health system needs an effective and low-cost way to provide optimal health outcomes using conversation-enabled Artificial Intelligence (AI). Humans can interact well with this AI in the form of a fully automated and self-contained text-based mobile tutoring service. CHD is a serious health problem worldwide with multiple and interrelated causes. At the same time, chatbots are becoming more popular for interacting with users in mobile health apps.Objective: We evaluated an Android application. Its main goal is to prevent lifestyle-related diseases that are a risk for CHD, which has been considered at risk for multiple coronary artery disease (CAD), with the overarching goal of gaining compassion through mobile health improvements. The insights gained in this preview article will be used to plan future health care systems and to design an AI capable of advanced healthcare, chronic disease prevention, and self-treatment.Results: The Role of Artificial Intelligence in preventing Coronary Heart Disease (CHD) is done through health screenings. The app warns the user to exercise regularly and maintain food intake by reducing foods high in calories and adding foods high in fiber. Conclusion: Usage of AI in healthcare is associated with CHD prevention, which alters healthy lifestyles. It can also encourage a change in attitude, a high level of user concern for health, and obtain complete health information. Research on artificial intelligence and its use in telemedicine needs to be continued, with clinical trials examining the impact on blood pressure, body mass index, smoking, diabetes mellitus, and user engagement and feedback.

Efektivitas Pasca Vaksinasi Hepatitis B di Kecamatan Pakal, Surabaya, Jawa Timur William Sayogo; Wira Widjaya Lindarto; Cempaka Harsa Sekarputri; Jemina Lewi Santoso; Stefani Nurhadi; Ferdinand Aprianto Tannus; Inez Purnomasari Prajitno
Gorontalo Journal of Public Health VOLUME 5 NOMOR 2, OKTOBER 2022
Publisher : Universitas Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32662/gjph.v5i2.2461

Hepatitis is an infectious disease that is still a concern today and is at risk of becoming a chronic condition with complications of liver function failure. Screening is carried out to determine the level of response of the body's defense system induced by the vaccine in the population of Pakal district, Surabaya. This study assesses the relationship between antibody status and protection status after vaccination. The study involved 78 people who are eligible to receive the vaccine. After receiving the vaccine, the antibody status is checked and the data obtained were statistically tested and tested for association using a contingency coefficient. From 78 hepatitis B vaccine recipients, 69 people (88,46%) are antibody reactive and 9 people (11.54%) with non-reactive antibody status. From the Chi Square test and the contingency coefficient test, it is shown that there is a relationship between antibody status and protection status (α<0.05; 95% CI). The hepatitis B vaccine provides protection against the risk of hepatitis B virus infection for residents of the Pakal district of Surabaya who have a high-risk lifestyle.

PROGRAM PENINGKATAN KESEHATAN REPRODUKSI ANAK DAN REMAJA LAKI-LAKI DI KECAMATAN SAMBIKEREP SURABAYA Erik Jaya Gunawan; Salmon Charles P.T. Siahaan; Etha Rambung; Stefani Nurhadi; David Ferdinandus; Fransisca Suyanto Pangemanan; Aura Dhiya Ulhaq; Stephanie Laurensia Budi; Wilhelmus Alvin Kaka; Samantha Debora Ang; Vincent Aurelius
Jurnal Pengabdian Masyarakat Bumi Raflesia Vol. 5 No. 2 (2022): Jurnal Pengabdian Kepada Masyarakat Bumi Raflesia
Publisher : Universitas Muhammadiyah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia memiliki demografi penduduk usia 10-19 tahun mencapai 16,47% dari total populasi. Berdasarakan data nasional, angka kekerasan seksual terhadap anak usia sekolah dan remaja masih tinggi. Selain itu, pandemi COVID-19 menyebabkan akses masyarakat terhadap pelayanan kesehatan juga terganggu. Tujuan dari kegiatan ini adalah meningkatkan pengetahuan dan akses layanan kesehatan terkait kesehatan reproduksi pada anak dan remaja laki-laki di kecamatan Sambikerep Surabaya. Metode yang kami gunakan untuk meningkatkan pengetahuan adalah memberikan penyuluhan materi, pemberian brosur, dan tanya jawab terkait masalah kesehatan reproduksi anak laki-laki. Sedangkan untuk meningkatkan akses pelayanan kesehatan reproduksi, kami mengadakan khitan gratis (oleh tim dokter yang kompeten) dan evaluasi luka operasi. Kegiatan diikuti oleh 75 orang (25 anak dan kedua orang tuanya) dan dilaksanakan di Universitas Ciputra Surabaya. Antusiasme peserta dan orang tua saat pemaparan materi dan sesi tanya jawab sangat baik. Orang tua semakin memahami pentingnya Pendidikan kesehatan reproduksi untuk anak. Kegiatan khitan gratis berjalan dengan lancer. Tidak didapatkan komplikasi selama Tindakan khitan ataupun saat evaluasi luka operasi (4 hari setelahnya). Kegiatan ini selain bermanfaat dalam memudahkan akses pelayanan kesehatan serta meningkatkan pengetahuan mengenai kesehatan reproduksi anak dan remaja. Peningkatan pengetahuan akan kesehatan reproduksi juga menjadi bekal dalam menghindari kekerasan seksual dan membangun sumber daya manusia yang sehat secara fisik dan mental yang merupakan modal utama bagi pembangunan bangsa dan negara di masa yang akan datang. Kata Kunci: kesehatan reproduksi, anak, remaja, laki-laki, khitan

EFFECTIVENESS OF CHATBOT TO REDUCE THE RISK OF CORONARY HEART DISEASE WITH DOKTERKIT MOBILE APPLICATION Agnes Atmadjaja; Minarni Watiningsih; Stefani Nurhadi
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 1 (2023): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i1.4415

Background: An innovative approach in the form of a discussion platform designed to help users deal with health issues related to coronary artery disease. Chatbot platforms allow the collection of users' data, which is analyzed through natural language processing and behavioral analysis to provide each user with a customized solution based on their current situation. The data collected and analyzed is accessible. The platform is developed using chatbot technology. Users can interact with chatbots to generate personal chat data stored on the platform.Conflicting information and sensitivity to Coronary heart disease (CHD) issues hinder effective communication. Recent technological solutions to maintain weight loss are limited. A chatbot would be suitable to support weight loss as it requires no human intervention, is available 24 hours a day, and supports natural communication while maintaining anonymity. CHD is a non-communicable disease with increased mortality in both developed and developing countries. It is a major public health problem worldwide. There are many risk factors for coronary heart disease, divided into primary risk factors (age, gender, genetics) and secondary risk factors (hypertension, smoking, dyslipidemia, diabetes, obesity, physical inactivity), and other risk factors (stress, alcohol, diet, and nutrition).The health system needs an effective and low-cost way to provide optimal health outcomes. Conversational Artificial Intelligence (AI) capabilities in the form of a fully automated and self-contained text-based mobile tutoring service. CHD is a serious health problem worldwide with multiple and interrelated causes. At the same time, chatbots are becoming more popular for interacting with users in mobile health apps.Objective: Dokterkit mobile application (available on the Google Play Store) prevents lifestyle-related diseases that are a risk for CHD, which has been considered to be at risk for multiple coronary artery disease (CAD), with the overarching goal of gaining compassion through mobile health improvements Opportunities for the healthcare of the heart. The insights gained in this preview article are used to plan future healthcare systems and design a system embedded with artificial intelligence to advance healthcare, chronic disease prevention, and self-treatment.Results: The Role of Artificial Intelligence in preventing Coronary Heart Disease (CHD) is to routinely carry out health screenings, make users aware of exercising regularly, and maintain food intake by reducing foods that are high in calories and adding foods that are high in fiber.Conclusion: Using AI in healthcare is associated with preventing CHD, which alters healthy lifestyles. It can also encourage a change in attitude, a high level of user concern for health, and obtain complete health information. Research on artificial intelligence and its use in telemedicine needs to be continued, with clinical trials examining the impact on blood pressure, body mass index, smoking, diabetes mellitus, and user engagement and feedback.

Vitiligo Fokal pada Anak Yang Diterapi dengan Target Excimer Light 308 nm Stefani Nurhadi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 2 (2019): EDISI SEPTEMBER 2019 (available online since Oktober 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Vitiligo is a acquired skin disease characterized by a well-defined depigmented macules caused by progressive loss of functional melanocytes. Vitiligo usually appears first during childhood or young adults. Management of vitiligo in children are more difficult because the preference of therapy is limited when compared with adult. Targeted 308 nm UVB phototherapy is used for local vitiligo in children as it can be focused on the lesion and reduce the side effects. A 4-year-old girl, came to dermato-venereology polyclinic of Indera Hospital Denpasar with complaints of white patch on her lips for 3 weeks. Based on the history and physical examination, she was diagnosed with focal vitiligo. She was treated with targeted 308 nm excimer light phototherapy three times a week. Five sessions of phototeraphy resulted good response characterized by repigmentation of the lesion without redness and blisters.The therapy aims to achieve the best results with minimal side effects. Phototherapy targets are recommended for local vitiligo and especially for new small lesions as well as pediatric vitiligo. The mechanisms of this phototherapy is to trigger repigmentation, stabilization, immunosuppression and immunomodulation. The conclusion is targeted 308 nm phototherapy is quite useful for treating vitiligo even though more therapy sessions are needed.

Elevated homeostatic model assessment of insulin resistance level increases the risk of acne Nurhadi, Stefani; Praharsini, IGAA; Wiraguna, AAGP
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Insulin resistance and high carbohydrate diets are currently considered to be influential in acne aetiology. Insulin is a hormone that does not only regulate the concentration of blood glucose but also affects the production of sebum and through the Insulin Growth Factor-1 (IGF-1) receptor stimulates androgen synthesis which will increase the proliferation of keratinocytes duct and the production of sebum in acne of the pilosebaceous. Methods: This is a cross sectional observational analytic study involving 38 acne patients and 38 controls. This study aims to determine whether the increase in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is a risk factor for acne. HOMA-IR formula was used to determine insulin activity in basal state. High HOMA-IR values are expressed from cut-off point ≥2. Subject was recruited with consecutive sampling who meets inclusion and exclusion criteria. Fasting insulin and blood glucose levels was derived from venous blood examination. Results: The average age of acne subjects was 23.71 years old in both groups (10 men and 28 women). The mean value of HOMA-IR in the acne group was higher (2.63 ± 0.29) than those in the control group (1.71 ± 0.26) and was statistically significant difference (p value <0.001). The prevalence ratio was 31.58, meaning that patients with high HOMA-IR were 31.6 times more likely to have acne than patients with normal HOMA- IR values. These results were statistically significant (p <0.001). Conclusion: Elevated HOMA-IR is one of the factors which increase the risk of acne development in an individual.

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