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All Journal Makara Journal of Science Suara Teknik : Jurnal Ilmiah
Mahendra, Isa
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Control & Systems Engineering Education Engineering Materials Science & Nanotechnology Mechanical Engineering

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Cellular Uptake and Computational Analysis of [131I]-Xanthine and [131I]-Hypoxanthine in Human Prostate Cancer Cell Line (LNCaP) Wongso, Hendris; Mahendra, Isa; Setiadi, Yanuar; Rattyananda, Badra Sanditya; Rizaludin, Asep; Pranisuari, Ni Made Yuktikamura Galih; Kusumaningrum, Crhisterra Ellen
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

Potent radiolabelled compounds eligible for therapy of prostate cancer need to be developed. Hence, we developed two candidate therapeutic agents bearing the iodine-131 (131I) radionuclide, namely, [131I]-xanthine (3,7-dihydropurine-2,6-dione) and [131I]-hypoxanthine (1,9-dihydro-6H-purin-6-one). The radiolabelled compounds were subjected to a cellular uptake study, which was accomplished by incubating [131I]-xanthine and [131I]-hypoxanthine with the human prostate cancer cell line (LNCaP) for 5, 15, 30, 60, and 90 min. Results showed that the accumulation of both [131I]-xanthine and [131I]-hypoxanthine in prostate cancer cells was significantly higher than the control group (131I). [131I]-xanthine rapidly accumulated in prostate cancer cells, with the highest percentage of cellular uptake of 2.73% ± 0.40% observed at 30 min of incubation. By contrast, [131I]-hypoxanthine exhibited more efficient accumulation in prostate cancer cells, especially at 60 and 90 min of incubation, with cellular uptake values of 11.5% ± 3.14% and 11.9% ± 1.83%, respectively. Furthermore, the computational analysis showed that radioiodinated xanthine and hypoxanthine provide potential binding affinities and interaction on both androgen and prostate-specific membrane antigen receptors. Overall, this study indicates that [131I]-xanthine and [131I]-hypoxanthine can be potentially developed as therapeutic agents for prostate cancer.
Strength Analysis of Welded Joints on the Frame Electric Bicycle Kholis, Nur; Purwanto, Helmy; Mahendra, Isa
Suara Teknik : Jurnal Ilmiah Vol 16 No 1 (2025): Suara Teknik: Jurnal Ilmiah - Mei
Publisher : Fakultas Teknik dan Ilmu Komputer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29406/stek.v16i1.7357

Abstract

This study aims to determine and analyze the electric bicycle frame on macro and micro structures, tensile testing, and hardness testing. This research uses hollow low carbon steel material with a length of 100 mm, width of 6 mm, and thickness of 2 mm. The method used is observation of macro and micro structures, vickers mickrohardness hardness testing. Furthermore, the specimens were welded with current variations of 100 A, 110 A, and 120 A with ASTM E8 design. From the observation of the macro structure, the best results are in the 110 A current variation compared to the 100 and 120 Ampere variations, because the 100 and 120 Ampere results experienced weld failure. The results of the microstructure test at a current of 100 A show that the pearlite phase dominates the parent metal and HAZ areas, while the welding area is dominated by Ferite. In testing the microstructure of 110 A current, it appears that pearlite dominates the parent metal and HAZ areas, while the welding area is dominated by martensite. In testing the microstructure of 120 A current can be seen in the parent metal and HAZ dominated by pearlite, while the welding area is dominated by martensite. From the Vicker microhardness test, the highest results in the welding area in the 120 A current variation and the lowest point in the parent metal in the 100 A current variation. The tensile test results show the highest value of yield stress 352.581 MPa and max stress 390.822 MPa shown in the 110 A current variation.
Co-Authors Helmy Purwanto Hendris Wongso Kusumaningrum, Crhisterra Ellen Nur Kholis Pranisuari, Ni Made Yuktikamura Galih Rattyananda, Badra Sanditya Rizaludin, Asep Yanuar Setiadi