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All Journal Journal of Islamic Pharmacy Folia Medica Indonesiana
Hidayah, Rohmawati
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Formulasi, Evaluasi Stabilitas Fisik dan Uji Aktivitas Antibakteri Serum Wajah Yang Mengandung Minyak Biji Anggur (Grape Seed Oil) Hidayah, Rohmawati; Hanifa, lif
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.18713

Abstract

Minyak biji anggur merupakan minyak yang diperoleh dari buah anggur yang mempunyai khasiat sebagai antioksidan yang dapat menambah kapasitas antioksidan di dalam tubuh. Dilihat dari kandungan, sediaan ini dapat memberikan aktivitas antibakteri terutama untuk bakteri penyebab jerawat yaitu bakteri Propionibacterium acnes. Sediaan serum dipilih sebagai bentuk sediaan yang diformulasikan karena belakangan populer dalam industri kosmetik, selain itu serum dapat diformulasikan sebagai produk dengan konsentrasi berbasis air atau minyak yang memiliki sifat penyerapan dan kemampuan menembus lapisan kulit lebih dalam.   Penelitian ini difokuskan untuk menciptakan produk komestik dengan bentuk serum wajah yang tidak hanya sebagai antiaging juga sebagai anti jerawat. Penelitian ini menguji berbagai konsentrasi minyak biji anggur yang dibuat dalam bentuk serum yaitu 2%, 4%, 6% untuk mempelajari aktivitas antibakteri penyebab jerawat, selain itu menguji stabilitas fisik pada penyimpann suhu kamar (28±2°) selama 30 hari.  Formula dengan konsentrasi minyak biji anggur 2% dan 4% stabil secara fisik, namun semua formula tidak menunjukan adanya zona hambar terhadap bakteri Propionibacterium acnes dan Staphylococcus aereus.
Effect of Combination Soy Bean Oil and Oleic Acid to Characteristic, Penetration, Physical Stability of Nanostructure Lipid Carrier Resveratrol Soeratri, Widji; Hidayah, Rohmawati; Rosita, Noorma
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Resveratrol is an antioxidant that can be used as anti-aging. Topical use has several problems because solubility in water is low and unstable to light. This study aimed to evaluate the effect of the combination of soy bean oil and oleic acid liquid lipids on the characteristics, penetration, and stability of resveratrol nanostructured lipid carriers (NLC). Nanostructured lipid carriers (NLC) were made with high shear homogeneous technique. To determine the characterization of NLC, diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry were used. Examination of the morphological form was carried out with a transmission electron microscope. The particle size and polydispersity index examination were measured by the Delsa Nanoâ„¢ particle size analyzer, while the efficiency of trapping resveratrol in the NLC system was measured by the dialysis membrane method. Furthermore, the penetration depth test on the skin of mice was done by fluorescence microscope method using rhodamine B markers. Physical stability test was performed by examination of particle size and index polydispersity for 30 days. The formula with liquid soy bean oil and oleic acid liquid lipids improved the characteristics including the effectiveness of entrapment and colloidal stability. However, the formula with soy bean oil and oleic acid combination liquid lipids did not provide better penetration into the skin than the use of single liquid lipids. While the formula with soy bean oil and oleic acid liquid lipids proved to improve the physical stability for 30 days.
Co-Authors Hanifa, lif Noorma Rosita Widji Soeratri