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All Journal Folia Medica Indonesiana INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Layanan Masyarakat (Journal of Public Service) Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan

Noorma Rosita

Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya

Author-ID : 331628

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Effect of Lipid Ratio of Stearic Acid and Oleic Acid on Characteristics of Nanostructure Lipid Carrier (NLC) System of Diethylammonium Diclofenac Hendradi, Esti; Rosita, Noorma; Rahmadhanniar, Erwinda
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of Â stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM). The results Â showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. On the other hand, it affected the pH of all formulas, which were significantly different. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles.Â

Preparation and Characteristics of NLC Coenzym Q10 with A Combination of Hyaluronic Acid Nurhidayah Sarifuddin; Widji Soerarti; Noorma Rosita
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Coenzyme Q10, often also known as ubiquinone, coenzyme Q10 or Q10, is soluble in lipids and is naturally present in plants, animals and in mitochondria. Coenzyme Q10 functions as an antioxidant that can protect the body from damage caused by free radicals. Hyaluronic acid is known as a hydrophilic polymer derived from polysaccharides which has the ability to increase percutaneous penetration by changing the composition of tightly arranged stratum corneum cells to increase the permeability of the skin. Nanostructured Lipid Carrier is a modification of the SLN system, consisting of a mixture of solid and liquid lipids (oil), stabilized by aqueous surfactant solution, is one method to increase drug penetration through the stratum corneum because it has several advantages. The purpose of this study was to see the effect of adding hyaluronic acid to the characteristics of the Nanostructure Lipid Carrier (NLC) as anti aging. Examination of characteristics including organoletis, pH, particle size and polidispersity index was carried out. The results of organoleptic NLC coenzym Q10-HA examination obtained dark orange color, liquid consistency, lipid efficacy odor and soft texture. The pH measurement results of the preparation ranged from 5.05-5.23. The results of the particle size examination ranged from 267-128 nm and the particle size distribution ranged between 0.308-0.200 Keywords: Coenzym Q10, Hyaluronic acid , NLC

EFFECT OF SOLID LIPID NANOPARTICLE (SLN) AND NANO STRUCTURE LIPID CARRIER (NLC) SYSTEM ON ANTIOXIDANT STABILITY OF TOMATO EXTRACT (LIPID: CETYL ALCOHOL AND ISOPROPYL MYRISTATE) Sayyidati Aqilah; Esti Hendradi; Noorma Rosita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tomato extract was known contains manyantioxidants (Chauhan et al., 2010), such aslycopene, that are easily degraded by UV-B rays. Themechanism lycopene as an antiaging is to reduceskin regeneration and increase the thickness of theepidermis (Sahasrabuddhe, 2011). As anantioxidant, lycopene easily degraded when exposedto light, heat, and oxygen (Chauhan et al., 2011).Drug delivery system based on nanolipid carriersystem, such as: Solid Lipid Nanoparticles (SLN) wasappropriate to stabilize lycopene, as lipophilicsubstance (Wissing and Muller, 2003; Helgason etal., 2009; and Okonogi dan Riangjanapatee, 2014).One of the limitations of SLN is the drug moleculethat has been trapped expulsed easily duringstorage. It is caused of the orderdness of lattice lipidcrystal. Replacement part of solid lipid using liquidlipid (called as nanostructure lipid carriers or NLC)can reduce the orderdness of lattice lipid crystall andit will repaired it (Kaur et al, 2015).In this research have been tried to be compared theability of SLN and NLC to improve the stability ofantioxidant tomato extract. Using 20% total amountof lipid, extract tomato-SLN made from cetyl alcoholas solid lipid and extract tomato-NLC made fromdifference ratio between cetyl alcohol and isopropylmyristate (IPM) such as: 9:1 and 7:3. Tween 80 andKollipor were used as surfactant and co-surfactant.IPM was choose because of its enhancer andemollient effect so easily to apply to the skin(Vadgama et al, 2015).

Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres Dewi Melani Hariyadi; Noorma Rosita; Tiara Jeni Rosadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 1 (2018): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%; 9.61%; 13.11%; and 15.09% respectively, while the entrapment efficiencies were 48.35%; 41.99%; 38.67%; and 30.53%. The yields were 80.92%; 74.12%; 68.27%; and 59.11% respectively. Based on the statistical analysis, it was found that there were significant differences between formulas. Particles of formulas decreased as the amount of drug increased. The resulting sizes were 1.82 Î¼m (F1); 1.96 Î¼m (F2); 2.1 Î¼m (F3); and 2.97 Î¼m (F4). Conclusion: It can be concluded that amount of drug significantly affected the characteristics of metformin-alginate microspheres.

Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol Noorma Rosita; Qurrotu A'yunin; Esti Hendradi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 1 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Ubiquinon atau Coenzyme Q10 (CoQ10) merupakan senyawa kimia yang tidak stabil terhadap cahaya, sehingga mudah terdegradasi. Oleh karena itu, sistem penghantaran yang bisa meningkatkan kestabilan dari CoQ10 sangat dibutuhkan. Solid lipid nanoparticles (SLN) diketahui mampu meningkatan stabilitas molekul, dan memiliki karakteristik pelepasan terkontrol. Karakteristik SLN (ukuran partikel dan efisiensi penjebakan obat), sangat dipengaruhi kompoen penyusun SLN. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan jenis kosurfaktan terhadap karakteristik SLN-CoQ10. SLN-CoQ10 dibuat dengan metode high shear homogenization pada kecepatan 24000 rpm selama 2 menit, 4 siklus. Metode: Pada penelitian ini dibuat empat formula SLN-CoQ10 dengan propilen glikol (A1), poloxamer 188 (B1), lesitin (C1) sebagai kosurfaktan dan pembanding tanpa kosurfaktan (D1). Hasil: Ukuran diameter partikel SLN-CoQ10 yang dihasilkan dari kosurfaktan propilen glikol, poloxamer 188, lesitin dan yang tanpa menggunakan surfaktan berturut-turut adalah: 556,1 ± 4,89; 174,1 ± 6,69; 220,4 ± 12,01 dan 556,8 ± 17,96 nm sementara itu persen efisiensi penjebakan yang dihasilkan berturut-turut adalah 32,47 ± 6,88; 77,38 ± 8,63; 19,77 ± 5,69; dan 16,09 ± 3,70 %. Kesimpulan: Berdasarkan hasil evaluasi karakteristik, disimpulkan bahwa SLN-CoQ10 yang dibuat dengan ko-surfaktan poloxamer 188 memiliki karakteristik yang paling baik karena memiliki ukuran partikel kecil dan persen efisiensi penjebakan yang paling besar dibandingkan dengan SLN-CoQ10 dengan formula yang menggunakan ko-surfaktan propilen glikol, lesitin atau yang tanpa kosurfaktan.

Karakteristik dan Stabilitas Fisik NLC-Koenzim Q10 dalam Sleeping Mask dengan Minyak Nilam Fransisca Dita Mayangsari; Tristiana Erawati; Widji Soeratri; Noorma Rosita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 2 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i22021.178-186

Pendahuluan: Minyak nilam memiliki efek antioksidan dan peningkat penetrasi. Minyak tersebut berpotensi meningkatkan efektivitas produk sleeping mask dengan Koenzim Q10 (KoQ10) yang dimuat dalam Nanostructured Lipid Carriers (NLC) sebagai kosmetik anti-penuaan. Tujuan: Membandingkan karakteristik dan stabilitas fisik dari NLC-KoQ10 yang dimuat dalam sleeping mask dengan dan tanpa minyak nilam. Metode: Preparasi NLC-KoQ10 menggunakan metode High Shear Homogenization. NLC-KoQ10 dicampur dengan hydrogel dan minyak nilam, untuk F2. Sedangkan untuk F1 tanpa minyak nilam. Setelah itu diamati karakteristik dan stabilitas fisiknya yang meliputi organoleptik, pH, dan viskositas. Uji stabilitas fisik diamati pada suhu ruang selama 90 hari. Hasil: Uji karakteristik fisik menunjukkan bahwa F1 memiliki bau seperti oleum cacao, sedangkan F2 memiliki bau khas minyak nilam dan sedikit bau seperti oleum cacao. F1 memiliki nilai pH 6,036 ± 0,011, sedangkan F2 memiliki nilai pH 6,062 ± 0,020. Tidak ada perbedaan yang signifikan. Namun, F1 dan F2 memiliki nilai viskositas yang berbeda. F1 memiliki nilai viskositas 199,2 ± 0,7 cp, sedangkan F2 memiliki nilai viskositas 175,6 ± 7,9 cp. Uji stabilitas fisik menunjukkan bahwa F1 dan F2 memiliki skala nilai pH berkisar 6,055 - 6,336 dan viskositas 175,6 - 239,7 cp. Nilai viskositas F1 mengalami peningkatan setelah hari ke-60, sedangkan F2 pada hari ke-90. Kesimpulan: Berdasarkan uji karakteristik dan stabilitas fisik dapat disimpulkan bahwa F1 dan F2 memiliki bau dan viskositas yang berbeda, dan F2 lebih stabil daripada F1.

Physicochemical Characteristics, Stability, and Irritability of Nanostructured Lipid Carrier System Stabilized with Different Surfactant Ratios Dyah Rahmasari; Noorma Rosita; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.8-16

Background: One of the vital variables affecting the stability and the characteristics of the Nanostructured Lipid Carrier (NLC) is the surfactant concentration. Using the two combinations of surfactants can cause higher stability and a better characteristic of NLC. Tween 80 and Span 20 are anionic surfactants whose combination has not been studied for use in NLC systems. Objective: Determine the effect of different surfactant ratios of Tween 80 and Span 20 on the physicochemical characteristics, stability, and irritability of NLC using the High Shear Homogenization (HSH) method. Methods: Four different surfactant ratios were used in the NLC formulation, in which the ratio of Tween 80:Span 20 were 5:5, 6:6, 7:7, and 8:8, respectively. In this NLC system, cetyl palmitate served as solid lipid, medium-chain triglyceride (CrodamolTM) as liquid lipid, Tween 80, and Span 20 as surfactant components. NLC was characterized for organoleptic, viscosity, pH, zeta potential, particle morphology, particle size, and polydispersity index (PDI), then evaluated for stability using the real-time and freeze-thaw method, and irritability effect. Results: The different ratios of Tween 80 and Span 20 had no significant effect on the particle size, PI, and irritation score of the NLC system. On the other hand, it influenced all formulas' pH value, viscosity, zeta potential, and stability. Conclusions: The different ratios of surfactant combination affect the characteristics and stability of the NLC system.

Effect of Combination Soy Bean Oil and Oleic Acid to Characteristic, Penetration, Physical Stability of Nanostructure Lipid Carrier Resveratrol Widji Soeratri; Rohmawati Hidayah; Noorma Rosita
Folia Medica Indonesiana Vol. 55 No. 3 (2019): September
Publisher : Faculty of Medicine, Universitas Airlangga

Resveratrol is an antioxidant that can be used as anti-aging. Topical use has several problems because solubility in water is low and unstable to light. This study aimed to evaluate the effect of the combination of soy bean oil and oleic acid liquid lipids on the characteristics, penetration, and stability of resveratrol nanostructured lipid carriers (NLC). Nanostructured lipid carriers (NLC) were made with high shear homogeneous technique. To determine the characterization of NLC, diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry were used. Examination of the morphological form was carried out with a transmission electron microscope. The particle size and polydispersity index examination were measured by the Delsa Nano™ particle size analyzer, while the efficiency of trapping resveratrol in the NLC system was measured by the dialysis membrane method. Furthermore, the penetration depth test on the skin of mice was done by fluorescence microscope method using rhodamine B markers. Physical stability test was performed by examination of particle size and index polydispersity for 30 days. The formula with liquid soy bean oil and oleic acid liquid lipids improved the characteristics including the effectiveness of entrapment and colloidal stability. However, the formula with soy bean oil and oleic acid combination liquid lipids did not provide better penetration into the skin than the use of single liquid lipids. While the formula with soy bean oil and oleic acid liquid lipids proved to improve the physical stability for 30 days.

PELATIHAN PEMBUATAN ES KRIM SAYURAN (MELORIN) KAYA KAROTEN SEBAGAI PROGRAM PEMBERDAYAAN IBU-IBU RUMAH TANGGA DI KECAMATAN GUBENG, SURABAYA Andang Miatmoko; Tutiek Purwati; Noorma Rosita; Muhammad Agus Syamsur Rijal; Dini Retnowati
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

The low consumption rate of vegetables and fruits in Indonesian population becomes major concerns for health improvement. Ice cream is a type of food that is favored by all people in various ages, even for adults. Training on making vegetable-based ice cream or melorin was held as an eﬀort to provide alternative intake form of vegetables and fruits. The training program was implemented with the partner are housewives community in Gubeng district, Surabaya, especially for those of residents of Gubeng and Mojo sub-districts areas, which have relatively big number of members. The training on making vegetable-based ice cream can be an alternative way to improve people’s nutrition and provide skills to empower local communities.AbstrakRendahnya angka kecukupan konsumsi sayur dan buah dibandingkan angka gizi seimbang pada penduduk Indonesia menjadi perhatian utama bagi upaya peningkatan kesehatan keluarga. Pelatihan pembuatan es krim berbasis sayuran atau melorin diadakan sebagai salah satu wadah untuk memberikan bentuk asupan sayur alternatif dikarenakan produk ini gemar dikonsumsi oleh berbagai kalangan, baik anak-anak, remaja, maupun dewasa. Program ini dilaksanakan dengan mitra sasaran adalah ibu-ibu rumah tangga anggota PKK di wilayah Kecamatan Gubeng Kotamadya Surabaya khususnya warga Kelurahan Gubeng dan Kelurahan Mojo, yang mana memiliki jumlah anggota yang berprofesi sebagai ibu rumah tangga relatif besar. Dengan demikian, pelatihan ini dapat menjadi salah satu upaya untuk memperbaiki gizi masyarakat sekaligus memberikan bekal keterampilan untuk pemberdayaan masyarakat setempat.

Penghambatan Interaksi Eutektik Akibat Energi Kompresi dengan Penambahan Pati Jagung Dwi Setyawan; Noorma Rosita; Diajeng Putri Paramita; Dicky Pratama
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

This research has been carried out to study inhibition of eutectic interaction which occurs on compressed binary mixture of ibuprofen-stearic acid by addition of corn starch. Corn starch was mixed into binary mixture of 40:60 (% b/b) ibuprofen-stearic acid with composition 10, 20, and 30% (w/w) and then compressed into tablet form. The physical characterization was conducted using tensile strength test, differential thermal analysis (DTA), powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), and scanning electron microscope (SEM). According to tensile strength test, the value was reduced upon addition of 10 and 20% corn starch compared to the compressed binary mixture. Addition 20% corn starch to compressed binary mixture shifted the eutectic diffraction peaks with a decline in intensity during PXRD study. Thermal analysis of compressed binary mixture-20% corn starch exhibited an increase in eutectic point, and FT-IR spectrum was observed no difference compared to the compressed binary mixture. SEM analysis indicated that 20% corn starch addition was able to inhibit sintering phenomena by dispersed on particle’s surfaces. Physical characterizations result in the conclusion that corn starch can inhibit the eutectic interaction between ibuprofen and stearic acid upon compression

Co-Authors Abhimata Paramanandana Agustin Agustin Agustin Agustin Albertus Aditya Setiawan Alya Nur Amilia Andang Miatmoko Angkasa Megistra Ulvan Ardhani Dwi Lestari1 Athiyyah, Wafa'ul Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Isadiartuti Dewi Melani Hariyadi Dian Ratna Rianti Dicky Pratama Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Firdausiah Fania Dwi Putri Putri Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hamdan, Siti Hartini Hanafi Tanojo Herra Studiawan I Gusti Ayu Adhi Aryapatni I Nyoman Wijaya Juni Ekowati Kholis Amalia Nofianti Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto Nurhidayah Sarifuddin Paramita, Diajeng Putri Pradita Fiqlyanur Isna Primadana Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Widyowati Rohmawati Hidayah Rufaidah Azzahrah Ryan Afandi Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Siti Hartini Hamdan Soerarti, Widji Sugiyartono1 Suko Hardjono Suzana Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tristiana Erawati Tutiek Purwanti Tutiek Purwati Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Widji Soeratri Winanda Rizki Febrianti Wiwik Handayani Yusuf, Helmy Zhihrotulwida, Dzakiya

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