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All Journal Indonesian Journal of Obstetrics & Gynecology Science
Saleh, Masagus Irsan
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Health Professions Public Health

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Correlation between Elevated Nerve Growth Factor mRNA Expression with Pain Intensity or Disease Severity in Endometriosis Octarina, Bertha; Abadi, Adnan; Hidayat, Syarief Taufik; Usman, Fatimah; Saleh, Masagus Irsan; Theodorus, Theodorus; Stevanny, Bella
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.908

Abstract

Objective: analyzed the relationship between NGF mRNA expression and pain levels and severity of endometriosis.Methods: This research involved 30 endometriosis patients undergoing surgery from November 2024 to April 2025. NGF mRNA expression was measured in blood plasma and ectopic tissue. Pain history was assessed retrospectively, and disease stage determined intraoperatively.Results: No significant relationship was found between NGF mRNA expression and pain levels or severity of endometriosis in either plasma or lesion tissue. Based on the Livak method analysis, the average value of relative expression of NGF gene mRNA increased 6.943-fold in blood plasma and 17.319-fold in endometriosis lesions of women with endometriosis. In the Mann Whitney test, there was a significant difference in the level of NGF gene mRNA expression between blood plasma and with p < 0.0001. NGF expression may not always correlate with disease severity because it is influenced by many factors.Conclusion: No significant correlation was found between NGF mRNA expression and endometriosis severity or pain intensity, but expression levels differed significantly between plasma and lesion tissue.
Co-Authors Adnan Abadi, Adnan Hidayat, Syarief Taufik Octarina, Bertha Stevanny, Bella Theodorus Theodorus Usman, Fatimah