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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Andalas obstetrics and gynecology journal
Adnan Abadi, Adnan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Acquired uterine arteriovenous malformation after cesarean section Usman, Fatimah; Sutrisno, Muhammad Al Farisi; Effendi, Kemas Yusuf; Abadi, Adnan; Manan, Heriyadi; Amran, Rizani; Zulqarnain, Iskandar
Majalah Obstetri & Ginekologi Vol. 32 No. 2 (2024): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I22024.148-155

Abstract

HIGHLIGHTS 1. Acquired uterine arteriovenous malformation (AVM) is an uncommon sequela of cesarean section, warranting consideration in instances of persistent uterine bleeding in the puerperium.2. Embolization represents a viable and well-established treatment modality for AVM, providing a safe and efficacious intervention that serves as an alternative, less invasive modality for patients desiring fertility preservation.   ABSTRACT Objectives: To demonstrate that embolization is a viable and well-established treatment for acquired arteriovenous malformations (AVMs), offering a safe and effective, less invasive option for patients seeking to preserve fertility.Case Report: A 20-year-old female experiencing recurrent massive bleeding with a history of previous caesarean section and wound infection resuturing. The transvaginal color Doppler ultrasound showed a hypervascularity in the uterus around the surgical lesion, suggesting a uterine AVM and its confirmed by angiography. The patient underwent a series of uterine artery embolization interventions, which proved to be a successful therapeutic approach. As a result of this treatment modality, not only was the patient's condition effectively resolved, but her fertility was also preserved.Conclusion: Acquired uterine arteriovenous malformation (AVM) is an uncommon sequela of cesarean section, warranting consideration in instances of persistent uterine bleeding in the puerperium. Embolization represents a viable and well-established treatment modality for AVM, providing a safe and efficacious intervention that serves as an alternative, less invasive modality for patients desiring fertility preservation.
Effectiveness of Vitamin D Therapy on the Lipid Profile of Patients with Polycystic Ovary Syndrome Usman, Fatimah; Abadi, Adnan; Effendi, Kms. Yusuf; Manan, Heriyadi; Andrina, Hana
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.522

Abstract

Polycystic ovary syndrome (PCOS) is characterized by chronic hyperandrogenism and anovulation that is also associated with various clinical and biochemical features. Vitamin D deficiency is a common problem that affects up to half of the adult population worldwide, including patients with PCOS. Based on these considerations, we are interested in further exploring the effectiveness of vitamin D in improving lipid profiles in PCOS.Efektivitas Terapi Vitamin D pada Profil Lipid Penderita Sindrom Ovarium PolikistikAbstrakSindrom Ovarium Polikistik (PCOS) ditandai dengan hiperandrogenisme kronis dan anovulasi yang juga berhubungan dengan berbagai gambaran klinis dan biokimia. Kekurangan vitamin D adalah masalah umum yang mempengaruhi setengah populasi orang dewasa di seluruh dunia, termasuk pasien PCOS. Tinjauan literatur ini dilakukan untuk mencari artikel asli dan review mengenai pertanyaan spesifik mengenai efektivitas terapi vitamin D terhadap profil lipid pasien PCOS.Kata kunci: PCOS, Lipid, Vitamin D
Non-Hormonal Pharmacological Interventions to Manage Vasomotor Symptoms During Menopause Hambali, Gilang Amanda; Abadi, Adnan
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.318

Abstract

This study reviews a range of non-hormonal pharmacological interventions used to treat vasomotor symptoms in postmenopausal women, including SSRIs, SNRIs, gabapentin, and neurokinin-3 receptor (NK3R) antagonists. Methods used included a literature review of multiple clinical trials and meta-analyses published over the past decade. Results showed that all interventions were effective in reducing the frequency and severity of hot flashes, with efficacy rates ranging from 36 to 72%. In addition, the side effect profile was generally mild to moderate, including nausea, sleep disturbance, and headache. NK3R antagonists, such as fezolinetant, have shown great promise with a rapid onset of action and comparable efficacy to hormone therapy, but longer-term studies are needed to assess safety. This study emphasizes the importance of an individualized approach to therapy selection and the need for monitoring liver function and potential side effects. Conclusions suggest that these non-hormonal interventions are a promising alternative for postmenopausal women for whom hormone therapy is contraindicated.
Correlation between Elevated Nerve Growth Factor mRNA Expression with Pain Intensity or Disease Severity in Endometriosis Octarina, Bertha; Abadi, Adnan; Hidayat, Syarief Taufik; Usman, Fatimah; Saleh, Masagus Irsan; Theodorus, Theodorus; Stevanny, Bella
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.908

Abstract

Objective: analyzed the relationship between NGF mRNA expression and pain levels and severity of endometriosis.Methods: This research involved 30 endometriosis patients undergoing surgery from November 2024 to April 2025. NGF mRNA expression was measured in blood plasma and ectopic tissue. Pain history was assessed retrospectively, and disease stage determined intraoperatively.Results: No significant relationship was found between NGF mRNA expression and pain levels or severity of endometriosis in either plasma or lesion tissue. Based on the Livak method analysis, the average value of relative expression of NGF gene mRNA increased 6.943-fold in blood plasma and 17.319-fold in endometriosis lesions of women with endometriosis. In the Mann Whitney test, there was a significant difference in the level of NGF gene mRNA expression between blood plasma and with p < 0.0001. NGF expression may not always correlate with disease severity because it is influenced by many factors.Conclusion: No significant correlation was found between NGF mRNA expression and endometriosis severity or pain intensity, but expression levels differed significantly between plasma and lesion tissue.
Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study Rizany, Selly; Abadi, Adnan; Agustiansyah, Patiyus; Nurtjahyo, Awan; Irfanuddin; Usman, Fatimah; Hartati; Mirani, Putri; Krisna, Ratih; Amran, Rizani; Prasetiyo, Muhammad Ath Thaariq
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.1947

Abstract

Objective: To assess the correlation between vitamin D levels, dysmenorrhea intensity measured by the visual analogue scale (VAS), and the stage of endometriosis determined by the American Society of Reproductive Medicine (ASRM) grading score. Methods: A cross-sectional study was conducted involving 37 women diagnosed with suspected endometriosis who met the inclusion and exclusion criteria. The aim was to determine the correlation between vitamin D levels, dysmenorrhea VAS scores, and the ASRM endometriosis stage at RSUP Dr. Mohammad Hoesin Palembang from November 2021 to April 2022. Bivariate analysis was employed to assess correlation, utilizing Pearson's correlation test and the Spearman Rank correlation test as an alternative method. Results: There was a significant positive correlation between vitamin D levels and the VAS score for dysmenorrhea (r = 0.678; p = 0.000) and a very strong positive correlation between vitamin D levels and the degree of endometriosis (r = 0.774; p = 0.000) based on Spearman Rho's correlation test. Conclusion: There is a significant relationship between vitamin D levels with the VAS score of dysmenorrhea and the degree of endometriosis ASRM. Keywords: american society of reproductive medicine, endometriosis, visual analogue scale, vitamin D
Correlation of Vitamin D and Antimullerian Hormone Level in Infertile Women with Polycystic Ovary Syndrome and Obesity Usman, Fatimah; Saleh, Irsan; Effendi, Kms. Yusuf; Putra, Hadrians Kesuma; Abadi, Adnan; Siahaan, Salmon Charles Pardomuan Tua; Kesty, Cindy; Rizda, Dian Permata; Stevanny, Bella; Lestari, Peby Maulina
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.723

Abstract

Introduction: Increasing amount of research indicates that women with PCOS are more likely to have a shortage in vitamin D with abnormally high anti-Müllerian hormone (AMH) levels. This study aims to assess the correlation between vitamin D and Anti-Mullerian Hormone (AMH) levels in infertile women with polycystic ovarian syndrome (PCOS) and obesity. Method: This observational cross-sectional study examined all obese women with PCOS who sought infertility treatment at Dr. Mohammad Hoesin Hospital Palembang from August 2021 to November 2021. PCOS diagnosis was determined using the Rotterdam criteria. All research subjects underwent a physical examination and transvaginal ultrasound to evaluate body mass index (BMI) and polycystic ovary morphology. Blood samples were collected to evaluate their testosterone, AMH, and vitamin D levels. Statistical analysis was performed using the Spearman correlation test with IBM® SPSS Statistics version 24. Results: Thirty infertile women with PCOS and obesity were included in the study, with average age of 31.17±4.48 years and average BMI of 33.45±2.67 kg/m2. The majority of the subjects had polycystic ovary morphology (86.7%) and oligomenorrhea (76.7%). No correlation between BMI and vitamin D as well as AMH levels was found in infertile women with PCOS and obesity. The Spearman test showed moderate negative correlation (p = 0.011. r = -0.458) between vitamin D and AMH levels in infertile women with PCOS and obesity. Conclusion: There is a moderate negative correlation between vitamin D and AMH levels among infertile women with PCOS and obesity. Further research is required to comprehend the role of vitamin D in female fertility.Korelasi Vitamin D dan Kadar Hormon Anti-Müllerian pada Wanita Infertil dengan Sindrom Ovarium Polikistik dan ObesitasAbstrakPendahuluan: Semakin banyak penelitian melaporkan bahwa wanita dengan PCOS cenderung mengalami defisiensi vitamin D dengan penignkatan kadar hormon anti-Müllerian (AMH). Penelitian ini bertujuan untuk mengkaji hubungan vitamin D dan kadar AMH pada wanita infertil dengan sindrom ovarium polikistik (SOPK) dan obesitas.Metode: Penelitian ini merupakan studi observasional potong lintang terhadap seluruh wanita infertil dengan SPOK dan obesitas yang di RSUP Dr. Mohammad Hoesin Palembang pada bulan Agustus 2021 hingga November 2021. Diagnosis SOPK ditegakkan berdasarkan kriteria Rotterdam. Seluruh subjek penelitian menjalani pemeriksaan fisik dan ultrasonografi transvaginal untuk menilai indeks massa tubuh (IMT) dan morfologi ovarium polikistik. Sampel darah dikumpulkan dari semua wanita untuk mengukur kadar testosteron, AMH, dan vitamin D. Analisis statistik dilakukan dengan menggunakan uji korelasi Spearman menggunakan IBM® SPSS Statistics versi 24.Hasil: Tiga puluh wanita infertil dengan SOPK dan obesitas dilibatkan dalam penelitian ini dengan usia rata-rata 31,17±4,48 tahun dan rata-rata IMT 33,45±2,67 kg/m2. Mayoritas subjek memiliki morfologi ovarium polikistik (86,7%) dan oligomenore (76,7%). Tidak ada korelasi antara IMT dan vitamin D maupun kadar AMH pada wanita infertil dengan SOPK dan obesitas. Uji Spearman menunjukkan korelasi negatif sedang (p=0.011.r=-0.458) antara kadar vitamin D dan AMH pada wanita infertil dengan SOPK dan obesitas. Kesimpulan: Kadar vitamin D berkorelasi negatif dengan kadar AMH pada wanita infertil dengan SOPK dan obesitas. Penelitian lebih lanjut diperlukan untuk memahami peran vitamin D pada kesuburan wanita.Kata kunci: Anti-Müllerian Hormone, Indeks Massa Tubuh, Obesitas, Sindrom Ovarium Polikistik, Vitamin D
The Relationship Between Stress Level And Menstrual Cycle In Final Level Of Sriwijaya University Medical Education Batch 2019 Prasetya, Bagus Eko; Abadi, Adnan; Purnamasari, Septi
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.267-273.2023

Abstract

Background: Menstruation is the discharge of blood and mucous tissue through the vaginafrom the uterus periodically every month with a span of 24-35 days. Menstruation can beaffected by stress. The burden of working on the final assignment coupled with learning thathas started to be done face to face makes students have to adjust to their daily habits. Thepurpose of this study was to find out whether there is a relationship between stress levels infinal year students of Sriwijaya University Medical Education class of 2019.Methods: This study uses a type of observational research, namely correlation analysis witha cross sectional approach. Data collection was carried out in October 2022 and obtained124 student data, then an analysis was carried out using the SPSS program and analyzedusing the Chi Square test.Results: From the results of the study, it was found that 124 respondents who experiencedmenstrual disorders were 47 (37.9%) while 77 (62.1%) experienced normal menstruation,then the most stress was severe stress, namely 43 (34.7). Then an analysis of the relationshipbetween stress and the menstrual cycle was carried out, the result was p = 0.009 / p <α(0.05), which means that there is a relationship between stress and the menstrual cycle.Conclusion: There is a relationship between stress levels and the menstrual cycle
Co-Authors Andrina, Hana Awan Nurtjahyo Effendi, Kemas Yusuf Effendi, Kms. Yusuf Hambali, Gilang Amanda HARTATI Hidayat, Syarief Taufik Irfanuddin Kesty, Cindy Krisna, Ratih Manan, Heriyadi Muhammad Irsan Saleh Octarina, Bertha PATIYUS AGUSTIANSYAH, PATIYUS Peby Maulina Lestari, Peby Maulina Prasetiyo, Muhammad Ath Thaariq Prasetya, Bagus Eko Purnamasari, Septi Putra, Hadrians Kesuma Putri Mirani Rizani Amran Rizany, Selly Rizda, Dian Permata Saleh, Masagus Irsan Salmon Charles Pardomuan Tua Siahaan Stevanny, Bella Sutrisno, Muhammad Al Farisi Theodorus Theodorus Usman, Fatimah Zulqarnain, Iskandar