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GAMBARAN FUNGSI GINJAL PASIEN DIABETES MELITUS TIPE II DI PUSKESMAS TLOGOSARI KULON KOTA SEMARANG Rukminingsih, Fef; Julianti, Carla
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.476

Type II Diabetes Mellitus (DMTII) patients who are not treated properly can experience decreased renal function. The use of oral hypoglycemic drugs (OHG) can cause a decrease in renal function. Glomerular Filtration Rate (GFR) can describe a decrease in renal function. The aim of this study was to determine the description of renal function in DMTII patients at the Tlogosari Kulon Health Center, Semarang City. This research is a descriptive observational study. The sampling technique used was purposive sampling. Data was obtained from medical records of DMTII patients for the period September–December 2022. The inclusion criteria were patients with DMTII who received OHG therapy for at least one year, aged ≥45 years, had the most recent serum creatinine examination, with or without comorbidities. If the patient's data is incomplete or the patient has a history of renal problems, they will be excluded. Based on the research results, it was discovered that there were 55 DMTII patients, consisting of 39 patients (70.90%) women and 16 patients (29.10%) men. A total of 29 patients were aged between 60-69 years (52.73%). A total of 39 patients had comorbidities such as hypertension and/or dyslipidemia. A total of 76.36% received OHG combination therapy. Forty percent of patients experienced a decrease in GFR from mild-moderate to severe. The decrease in GFR is caused by the amount of OHG consumed and comorbid hypertension

BIAYA MEDIK LANGSUNG KEMOTERAPI PASIEN KANKER KOLOREKTAL RUANG PERAWATAN KELAS 3 PESERTA JKN RUMAH SAKIT “X” DI KOTA SEMARANG Kurniawati, Fransisca Tri; Rukminingsih, Fef
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.738

Colorectal cancer (CRC) is the second most common cancer in men after lung cancer. The cost of CRC therapy is very high. The National Health Insurance (NHI) through BPJS covers the direct medical costs of CRC patients. One of the therapies for CRC patients is chemotherapy. Based on its level, chemotherapy is classified into mild, moderate and severe chemotherapy. This study aims to determine the average direct medical costs of mild chemotherapy in CRC patients in class 3 treatment rooms at “X” Hospital in Semarang City. This study is a descriptive observational study, using retrospective data. Data were obtained from medical records (MR) and billing data for CRC patients participating in NHI who underwent mild chemotherapy (C-4-13-I) for the period January–June 2023. The inclusion criteria were CRC patients with ICD code Z5.1.1, aged 18-65 years, class 3 treatment rooms. Patients who upgrade their class treatment rooms are excluded. Data processing was carried out by calculating the average direct medical costs based on patient billing. The results of the study obtained 79 chemotherapy billing data for CRC patients. Most patients were >45 years old, namely 69 patients (87.34%), male as many as 63 patients (79.75%). The most common chemotherapy regimens were FOLFIRI (59.49%) and FOLFOX (34.18%). The average length of treatment was 4.3 days. The largest direct medical cost components were medical and health personnel costs (45.17%) and drug costs (37.22%). The average direct medical cost for mild chemotherapy in class 3 treatment rooms was IDR 2,490,615.

PENGUKURAN TEKANAN DARAH PADA PASIEN GAGAL JANTUNG KONGESTIF DI INSTALASI RAWAT INAP RUMAH SAKIT ST. ELISABETH SEMARANG Rukminingsih, Fef; Susanto, Theresia Carolina
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 1 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i1.64

Congestive heart failure (CHF) is one of the top 10 diseases in the Inpatient of. St. Elisabeth Hospital Semarang. The main cause of CHF is hypertension. CHF patients receive antihypertensive therapy to control their blood pressure. This study aims to determine the decrease in blood pressure of CHF patients and the suitability of blood pressure of CHF patients with their treatment targets according to the Eighth Joint National Committee (JNC VIII) at the Inpatient Installation of St. Elisabeth Hospital Semarang. This research is an observational descriptive study, using retrospective data. Data was taken from medical records of CHF patients in inpatients who received antihypertensive therapy for the period October - December 2017, 40 years or older, with or without concomitant diseases. Based on the results of tracing of medical records it is known that the number of CHF patients who met the inclusion criteria was 60 people, consisting of 30 male patients and 30 female patients. A total of 35 patients (58.33%) were aged over 60 years. A total of 19 patients had concomitant diabetes mellitus type 2 and / or chronic kidney failure. A total of 51 patients (85%) during hospitalization experienced an average reduction in systolic BP of 21.65 mmHg and as many as 37 patients (61.67%) experienced an average reduction in diastolic BP of 13.38 mmHg. The suitability of the patient's blood pressure when leaving the hospital with the target blood pressure according to JNC VIII is 81.67%. Thus the progression of cardiac deterioration in most CHF patients can be inhibited.

EVALUASI PERESEPAN PADA PASIEN GERIATRI DI KLINIK PENYAKIT DALAM INSTALASI RAWAT JALAN RSUD K.R.M.T WONGSONEGORO SEMARANG Mulyani, Tri; Rukminingsih, Fef
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.82

The medical problems encountered in geriatric patients cause the prescribing to be susceptible to polypharmacy so that the possibility of creating Drug Related Problems (DRPs) is likely. Beers Criteria is one method to avoid the occurrence of DRPs. This study aims to evaluate prescribing of geriatric patients based on the Beers Criteria 2015 at the internal medicine clinic in the outpatient installation of K.R.M.T Wongsonegoro Hospital Semarang. This research was an descriptive observational study using retrospective data from geriatric patients' medical records at the internal medicine clinic in the outpatient installation of K.R.M.T Wongsonegoro Hospital Semarang in the period October - December 2017. A total of 300 medical records were taken at simple random as samples. Data for each patient were only taken once during the study period. The patient is a national health insurance participant and is ≥60 years old. The data obtained was then identified using Beers Criteria 2015. Based on the prescription of 300 geriatric patients in the internal medicine clinic in Wongsonegoro Hospital Semarang, it is known that 88,33% patients received prescription included in Beers Criteria 2015. The five medicine most prescribed are Na diclofenac, omeprazole, digoxin, ranitidine, and diazepam. Medications included in Beers Criteria are medicine that should not be given to geriatric patients so that caution is needed in the use of these medicine.

ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DI RUANG THERESIA RUMAH SAKIT ST. ELISABETH SEMARANG DENGAN METODE ATC/DDD Rukminingsih, Fef; Apriliyani, Apriliyani
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 1 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i1.110

The high incidence of infectious diseases causes the use of antibiotics to increase. Inappropriate use of antibiotics will lead to resistance. Infectious diseases are included in the top 10 diseases in pediatric patients at St. Elisabeth Hospital.Semarang. This study aims to evaluate the use of antibiotics in pediatric patients in the Theresia ward of St. Elisabeth Hospital Semarang. This research is a descriptive observational study using retrospective data. Data were taken from medical records of pediatric patients in the Theresia ward at St. Elisabeth Hospital Semarang, aged 6 months - 14 years, the use of antibiotic therapy during the period October - December 2019. The data obtained were analyzed by calculating the quantity of antibiotic use using the Anatomical Therapeutic Chemical (ATC) and Defined Daily Dose (DDD)) / 100 patient-days methods. Based on the results of tracing medical record data, it was found that the number of pediatric patients in the Theresia room at St. Elisabeth Semarang for the period October - December 2019 is 385. The number of patients who received a single antibiotic was 162. The total value of DDD / 100 patient-days in the Theresia ward of St. Elisabeth Hospital Semarang for the period October - December 2019 is 18.17 with a total length of stay of 1117 days. The antibiotic with the highest DDD / 100 patient-days was ceftriaxone, namely 15.10. While the antibiotics that enter the DU 90% segment are ceftriaxone and cefotaxime.

LAJU FILTRASI GLOMERULUS PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK Rukminingsih, Fef; Widiastuti, Mei
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 3 (2021): Jurnal Riset Kefarmasin Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i3.179

Diabetes Mellitus (DM) Type II is a group of metabolic diseases with hyperglycemia characteristics. The use of oral hypoglycemic drugs (OHO) lasts for a relatively long time. Most of the OHO is excreted through the kidneys. This study aims to determine the Glomerulus Filtration Rate (GFR) of type 2 DM patients who use OHO at the "X" Hospital, District of Demak. This study is an observational descriptive study using retrospective data obtained from medical record data (RM) of outpatient JKN participants with type 2 DM for the period October-December 2020. Inclusion criteria were patients who received OHO for at least one year with or without comorbidities, aged 36-65 years, and had a serum creatinine test. Patients receiving combination therapy with insulin were excluded. LFG is calculated using the Cockroft-Gault formula. From 82 patients, 52 patients (62.2%) were female, 74 patients (90.2%) were more than 45 years old. Patients who consumed OHO for more than 2 years were 47 (57.3%). Patients without comorbidities were 62 (75.7%) people. Patients who experienced a decrease in GFR in the moderate category (stage 3) as many as 24 people (29.3%), a decrease in GFR in the severe category (stage 4) as many as 5 people (6.1%) and 1 person (1.2%) experienced End Stage Renal Disease.

GAMBARAN FUNGSI HATI PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK PERIODE OKTOBER-DESEMBER 2020 Pangestuningsih, Megi; Rukminingsih, Fef
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.262

Type II DM patients use Oral Antidiabetic Agent (OAA) continuously for a long time. OAA metabolism occurs in the liver. The use of OAA continuously in the long term can cause liver function disorders. The purpose of this study was to describe the liver function of type II DM patients who were treated with OAA in a private hospital in Demak District. This study is an observational descriptive study using retrospective data obtained from medical record documents of outpatients with type II DM for the period October – December 2020. Sampling using purposive sampling technique. The inclusion criteria were outpatients with type II DM, JKN participants who received OAA therapy for at least one year, aged 36 – 65 years old, have AST and ALT laboratory examinations. Patients who received combination therapy with insulin, had a history of impaired liver function were excluded. The results showed that from 62 patients there were 39 female patients (62.9%), the most patients aged 56-65 years were 32 patients (51.61%). The longest duration of use of OAA was 1 year, namely 29 patients (46.77%). The most widely used OAA was a combination of biguanides and sulfonylureas in 36 patients (58.07%). A total of 51 patients (82.25%) did not experience liver function damage and as many as 11 patients (17.75%) showed mild liver function damage with the duration of using OHO for more than 1 year and using OHO combination.

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