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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi JOPS (Journal Of Pharmacy and Science) Jurnal EduHealth Journal of Social Research Media Keperawatan: Politeknik Kesehatan Makassar
Alyidrus, Rugayyah
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PENENTUAN KADAR LUNACRIDINE PADA EKSTRAK KAYU SANREGO (LUNASIA AMARA BLANCO) YANG DIEKSTRAKSI DENGAN METODE MASERASI DAN REFLUKS Alyidrus, Rugayyah
Jurnal Ilmiah As-Syifaa Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Determination of the research done on the extract lunacridine Sanrego (L. amara Blanco) in extraction with various methods of extraction. This study aims to determine the various menthods of extraction (maceration, refluks and soxhletasi) are most appropriate to extractim sanrego lunacridine on wood extract (L. amara Blanco) and determine the levels with TLC-Densitometry. Wood sanrego (L.amara Blanco) extrac dusing methanol solvent. Lunacridine as marker and sample in TLC and eluted wiyh the eluent n-hexane:ethyl acetate (2:8) and then scanned with a TLC-Densitometry of wavelength 303 nm. The results showed that the most appropriate extraction method is refluks with quote lunacridine content 37,52 µg/µL  that in maceration 35,03 µg/µL .
Formulasi dan Uji Efektivitas Sediaan Lip cream dari Ekstrak Etanol Biji Buah Merah (Pandanus conoideus L) sebagai Pewarna Alami dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrihidrazil) Primadani, Nur Baetty; Alyidrus, Rugayyah; Farid, Nurfiddin; Auliah, Nielma
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4173

Abstract

Formulation and Effectiveness Test of Lip Cream Preparations from Ethanol Extract of Red Fruit Seeds (Pandanus conoideus L) as A Natural Dye Using The DPPH (1,1-Diphenyl-2-Pikrihidrazil) Method. Red fruit seeds are botanical specimens that possess keratenoid chemicals, specifically b-carotene and a-carotene, which exhibit antioxidant properties. The objective of this study is to develop a stable Lipcream formulation and measure the IC50 value of the lipcream prepared from the ethanol extract of red fruit seeds (Pandanus conoideus L), which has antioxidant properties. An experimental research approach utilizing a solvent maceration technique with a solvent concentration of 96%. The obtained concentrated extract was subjected to rotation, followed by the fabrication of solutions with concentrations of 2%, 4%, and 6%, utilizing beeswax as a thickening agent. Kaolin is used as a texturizer. The emollients used are castor oil, cetyl alcohol, and dimethicon. Methyl paraben and propyl paraben are utilized as preservatives. Titanium dioxide serves as a pigment. The scent of vanilla. The preparation was evaluated by a cycling test consisting of 6 cycles over a period of 12 days. Organoleptic observations revealed a semi-solid texture, cream-like form, and a vanilla scent. The homogeneity test yielded consistent results, with pH measurements exceeding 0.05p, spreadability test results surpassing 0.05p, and adhesiveness test results meeting the specified standards. In addition to doing antioxidant testing, the DPPH method is employed using a UV-Vis spectrophotometer. The research findings indicate that the ethanol extract derived from red fruit seeds (Pandanus conoideus L) can be effectively made into a stable lip cream formulation, both in terms of its physical and chemical properties. The IC50 values obtained from the lip cream formulation including the ethanol extract of red fruit seeds (Pandanus conoideus L) were 59,496 ppm, 52,817 ppm, and 5,581 ppm, respectively. Formula 3 contains the most potent antioxidant value among all lip cream preparations.
Anti-Inflammatory Gel Preparation From Srikaya Leaf Extract (Annona Squamosa L.) In Male White Rats (Rattus Norvegicus) Alyidrus, Rugayyah; Abbas, Reky; Junita, Nurfitria; T, Ummu Kalsum; Alydrus, Nur Laela
Journal of Social Research Vol. 4 No. 7 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i7.2650

Abstract

Soursop leaves (Annona squamosa L.) contain flavonoids whice work by inhibiting the cyclooxygenase enzyme whice occurs in inflammation, an anti-inflammatory drug agent whice works against the process of inflammation or onflammation, the body’s response to tissue damage caused by physical trauma, chemical substances and microbiology which can be characterized by redness, heat, pain, swelling. This study was conducted to determine whether the ethanol extract of soursop leaves (Annona squamosa L.) can be used as a gel preparation that is stable against chemical physics and to determine whether the gel preparation can provide anti inflammatory effects on male white rat (Rattus norvegicus). The method used in this study was a laboratory experiment, with soursop leaves extracted in the maseration method using 96% ethanol solvent, then formulated in a gel preparation with a concentration of 5 %, 6 %, 7 % follewed by evaluation of the organoleptic test preparation, pH, spreadability, viscosity or cycling test and anti inflammatory test using yhe 1 % carrageenan induction method using 15 rats. The results of the anti inflammatory test, the soursop leaf extract gela preparation in male white rats met teha stability of the gel preparation and the anti inflammatory test obtained a significant value (p>0.05) where at a concentration of 5 % it already had an anti inflammatory effect. Ethanol extract of soursop leaves can be made into a gel preparation that is physically and chemically stable and can provide anti inflamatory effectiveness in male shite mice.
Uji Antiangiogenesis Secara In Vivo Ekstrak Etanol Biji Kopi Robusta (Coffea Robusta) dengan Metode Chorio Allantoic Membrane (CAM): Antiangiogenesis Test In Vivo Extract of Robusta Coffee Beans (Coffea robusta) Using Chorio Allantoic Membrane (CAM) Method Yusuf, Muhammad; Alyidrus, Rugayyah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.895 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14975

Abstract

Angiogenesis is a process of forming new capillaries found in the blood vessel system. Angiogenesis plays an important role in tumor growth and metastasis which includes several biological processes. Cancer cells require a supply of nutrients through the blood vessels to grow and develop so that the cancer cells secrete growth substances to stimulate the formation of new blood vessels to meet their nutritional supply. Robusta coffee beans (C.robusta) contain compounds that function as strong antioxidants namely Chlorogenic acid which is a polyphenol group compound that is thought to have antiangiogenesis effects. This study aims to look at the antiangiogenesis potential of robusta coffee bean ethanol extract (C.robusta) with the Chorio Allantoic Membrane (CAM) method and determine the concentration of robusta coffee bean extract (C.robusta) which has the potential as an antiangiogenesis. Antiangiogenesis test using the Chorio Allantoic Membrane (CAM) method using 9-day-old chicken eggs. In this study eggs were divided into 4 groups, group I was the untreated group, groups II, III, IV were groups that were given ethanol extract of robusta coffee beans (C.robusta) with concentrations of 6000 μg/ml, 5500 µg/ml respectively. and 5000 µg/ml. The eggs are re-incubated for 72 hours. In this study, a macroscopic semi-quantitative score was observed. The score data obtained were analyzed statistically by the One Way Anova test. Based on the Saphiro Wilk normality test results, the results of observations of antiangiogenesis in ethanol extracts of Robusta (Coffea robusta) concentrations of 6000 μg/ml, 5500 μg/ml, and 5000 μg/ml obtained a significance value of 0.248 (p>0.05). Continuing the One Way Anova test in the antiangiogenesis test obtained a significance value of 0.007 (p<0.05). Then proceed with the Post Hoc Test. In the test group the concentration of 6000 µg/ml, 5500 µg/ml, and 5000 µg/ml had a value of p>0.05 which means that there were no differences between groups in inhibiting angiogenesis. Based on the results of the study it can be concluded that the ethanol extract of robusta coffee beans (C. robusta) 6000 μg/ml, 5500 μg/ml, and 5000 μg/ml has antiangiogenesis effect on Chorio Allantoic Membrane (CAM) of chicken embryo.
The Effectiveness of Ethanol Extract Gel of Cumin Leaves (Plectranthus Amboinicus) toward White Male Rat (Rattus Novergicus) Alyidrus, Rugayyah; Alydrus, Nur Laela; Wahyuni, Wahyuni; Awaluddin, Nurhikma; Tangden, Nopianti
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

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Abstract

The leavers of white cumin (Plectranthus amboinicus) are a species of the family. Lamiaceae, previously known as Coleus amboinicus, contains quertesin compounds that are effective in healing wounds. The purpose of this study was to determine the extract of the leaves of white cumin (Plecranthus amboinicus) can be formulated for gel readiness and can affect the healing of cuts in white male rats (Rattus novergicus). The research method was laboratory experimental with the One Group Pretest- posttest research design. The leaves of white cumin (Plectranthus amboinicus) were extracted using 96% ethanol by maceration process and made into a gel form with a concentration of 3%, 5 %, and 7%. Evaluation of the physical and chemical stability of the gel before and after the cycling test for 6 cycles. This study used 15 male white rats divided into 5 groups, each group consisting of 3 and wounded with a depth of 2 cm and a length of 3 cm. the first male white rats were given a gel concentration of 3 %, the second 5%, the third 7 %, the fourth was given a gel without extract (negative control) and fifth was given 10 of octenilin gel (positive control). The incision length was measured on day 1,3,6,9,11,13 then data analysis used the ANOVA and SPSS 22 version. The results showed that leavers of white cumin (Plectranthus amboinicus) extract was p˂ 0,05, so there was a significant difference between each treatment. It can be concluded that gel readiness can be formulated and can affect wound healing in white male rats (Rattus novergicus).
Formulation and Activity Test Of Oil Spray Deodorant Preparations In Black Cumin Seeds (Nigella Sativa L.) Against Staphylococcus Epidermidis Causes Of Body Odor Alyidrus, Rugayyah; Ramadhani, Rezki; Santi, Elvira; Awaluddin, Nurhikma; Alydrus, Nur Laela
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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Abstract

Staphylococcus epidermidis bacteria are able to convert amino acids into isovaleric acid which causes unpleasant odors. This research aims to determine whether the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray physically stable and it has activity against Staphylococcus epidermidis which causes body odor. The research method was laboratory experimental using water distillation to extract essential oils and formulate deodorant spray preparations with concentrations of F1 (1%), F2 (3%), and F3 (5%). Evaluation of preparations includes organoleptic tests, homogeneity tests, pH tests, viscosity tests, spray pattern tests, dry time tests, emulsion type tests, irritation and hedonic tests, stability tests and antibacterial activity tests of preparations. The results of the research showed that the evaluation of the deodorant spray preparation of essential oil of black cumin seeds (Nigella sativa L.) had a P value of >0.05 so that this preparation was physically stable, while the statistical results of the antibacterial activity test obtained a P value of <0.05 indicating that there was a significant difference. This preparation has different activity diameters, including F1 (1%) in the medium category at 8.47 mm, F2 (3%) and F3 (5%) in the strong category with activity above 10-20 mm. It was concluded that the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray that is physically stable and has activity against Staphylococcus epidermidis which causes body odor
IMPLIKASI TEMUAN TOXOPLASMA GONDII PADA PEMELIHARA KUCING LOKAL TERHADAP PERAN PERAWAT DALAM PENCEGAHAN ZOONOSIS DI MASYARAKAT: Implications of Toxoplasma gondii Findings Among Local Cat Owners for the Role of Nurses in Community Zoonosis Prevention Alyidrus, Nur Laela; Sudirman, Andi Aridhasari; Sudirman, Andi; Alyidrus, Rugayyah; Dalle, Ambo
Media Keperawatan: Politeknik Kesehatan Makassar Vol 16 No 2 (2025): Media Keperawatan: Poltekkes Kemenkes Makassar
Publisher : Jurusan Keperawatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jmk.v16i2.1760

Abstract

ABSTRACT Background: Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, with cats (Felis catus) serving as the definitive host. The parasite spreads through millions of oocysts shed in feline feces, which can survive in the environment for weeks. In Indonesia, the prevalence of toxoplasmosis remains high, especially in Makassar, where human seropositivity reaches 60%. Despite this, awareness of toxoplasmosis remains low, even though the infection can cause serious complications such as congenital toxoplasmosis, miscarriage, and encephalitis. Methods: This study used a descriptive observational design with secondary data from PCR testing for Toxoplasma gondii in blood samples of local cat owners in Antang Raya, Makassar. Characteristics assessed included age, gender, number of cats owned, duration of ownership, and hygiene practices. Results: The findings showed that 38.5% of respondents tested positive for Toxoplasma gondii, with the highest exposure occurring in the productive age group (16–30 years). The study also found that infection occurred regardless of routine hygiene practices, highlighting that animal hygiene alone is insufficient to prevent transmission. Conclusion:These results emphasize the strategic role of nurses in zoonotic disease prevention, particularly through community-based health education, early detection, environmental sanitation promotion, and reproductive health advocacy. Strengthening the role of nurses in preventive efforts is essential to reduce the risk of toxoplasmosis transmission and its impact on public health, especially among women of reproductive age. Keywords: Toxoplasma gondii, zoonosis, cat owners, nursing, prevention  ABSTRAK Latar Belakang: Toxoplasmosis merupakan penyakit zoonosis yang ditularkan oleh parasit Toxoplasma gondii dan sering kali tidak disadari masyarakat karena gejalanya bersifat asimptomatik. Kucing lokal (Felis catus) sebagai hospes definitif memiliki peran besar dalam penyebaran ookista yang dapat mencemari lingkungan. Prevalensi toxoplasmosis di Indonesia tergolong tinggi, termasuk di Makassar yang mencapai 60%. Infeksi ini berpotensi berdampak serius terhadap kesehatan reproduksi, kehamilan, serta meningkatkan risiko gangguan sistem saraf, sehingga diperlukan upaya pencegahan berbasis keperawatan komunitas. Metode: Penelitian ini menggunakan desain deskriptif observasional berdasarkan data sekunder hasil deteksi Toxoplasma gondii menggunakan metode Polymerase Chain Reaction (PCR) pada darah pemelihara kucing lokal di Kecamatan Manggala, Makassar. Karakteristik responden meliputi usia, jenis kelamin, jumlah dan lama memelihara kucing, serta kebiasaan perawatan hewan. Hasil: Sebanyak 38,5% responden terdeteksi positif Toxoplasma gondii, dengan kelompok usia produktif (16–30 tahun) menunjukkan proporsi paparan tertinggi. Ditemukan bahwa infeksi tetap terjadi meskipun sebagian partisipan rutin menjaga kebersihan hewan, yang menunjukkan perlunya upaya pencegahan lebih menyeluruh. Kesimpulan: Tingginya angka infeksi Toxoplasma gondii pada pemelihara kucing lokal menunjukkan pentingnya intervensi pencegahan berbasis keperawatan. Perawat berperan strategis sebagai penyuluh kesehatan, fasilitator deteksi dini, promotor sanitasi lingkungan, dan advokat kesehatan reproduksi guna menekan penyebaran zoonosis di masyarakat. Kata kunci: Toxoplasma gondii, zoonosis, pemelihara kucing, peran perawat, pencegahan
Co-Authors Abbas, Reky Alydrus, Nur Laela Alyidrus, Nur Laela Ambo Dalle Auliah, Nielma Farid, Nurfiddin Junita, Nurfitria Muhammad Yusuf Nurhikma Awaluddin Primadani, Nur Baetty Ramadhani, Rezki Santi, Elvira Sudirman, Andi Sudirman, Andi Aridhasari T, Ummu Kalsum Tangden, Nopianti wahyuni wahyuni