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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal EduHealth
Alyidrus, Rugayyah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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PENENTUAN KADAR LUNACRIDINE PADA EKSTRAK KAYU SANREGO (LUNASIA AMARA BLANCO) YANG DIEKSTRAKSI DENGAN METODE MASERASI DAN REFLUKS Alyidrus, Rugayyah
Jurnal Ilmiah As-Syifaa Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Determination of the research done on the extract lunacridine Sanrego (L. amara Blanco) in extraction with various methods of extraction. This study aims to determine the various menthods of extraction (maceration, refluks and soxhletasi) are most appropriate to extractim sanrego lunacridine on wood extract (L. amara Blanco) and determine the levels with TLC-Densitometry. Wood sanrego (L.amara Blanco) extrac dusing methanol solvent. Lunacridine as marker and sample in TLC and eluted wiyh the eluent n-hexane:ethyl acetate (2:8) and then scanned with a TLC-Densitometry of wavelength 303 nm. The results showed that the most appropriate extraction method is refluks with quote lunacridine content 37,52 µg/µL  that in maceration 35,03 µg/µL .
Uji Antiangiogenesis Secara In Vivo Ekstrak Etanol Biji Kopi Robusta (Coffea Robusta) dengan Metode Chorio Allantoic Membrane (CAM): Antiangiogenesis Test In Vivo Extract of Robusta Coffee Beans (Coffea robusta) Using Chorio Allantoic Membrane (CAM) Method Yusuf, Muhammad; Alyidrus, Rugayyah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.895 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14975

Abstract

Angiogenesis is a process of forming new capillaries found in the blood vessel system. Angiogenesis plays an important role in tumor growth and metastasis which includes several biological processes. Cancer cells require a supply of nutrients through the blood vessels to grow and develop so that the cancer cells secrete growth substances to stimulate the formation of new blood vessels to meet their nutritional supply. Robusta coffee beans (C.robusta) contain compounds that function as strong antioxidants namely Chlorogenic acid which is a polyphenol group compound that is thought to have antiangiogenesis effects. This study aims to look at the antiangiogenesis potential of robusta coffee bean ethanol extract (C.robusta) with the Chorio Allantoic Membrane (CAM) method and determine the concentration of robusta coffee bean extract (C.robusta) which has the potential as an antiangiogenesis. Antiangiogenesis test using the Chorio Allantoic Membrane (CAM) method using 9-day-old chicken eggs. In this study eggs were divided into 4 groups, group I was the untreated group, groups II, III, IV were groups that were given ethanol extract of robusta coffee beans (C.robusta) with concentrations of 6000 μg/ml, 5500 µg/ml respectively. and 5000 µg/ml. The eggs are re-incubated for 72 hours. In this study, a macroscopic semi-quantitative score was observed. The score data obtained were analyzed statistically by the One Way Anova test. Based on the Saphiro Wilk normality test results, the results of observations of antiangiogenesis in ethanol extracts of Robusta (Coffea robusta) concentrations of 6000 μg/ml, 5500 μg/ml, and 5000 μg/ml obtained a significance value of 0.248 (p>0.05). Continuing the One Way Anova test in the antiangiogenesis test obtained a significance value of 0.007 (p<0.05). Then proceed with the Post Hoc Test. In the test group the concentration of 6000 µg/ml, 5500 µg/ml, and 5000 µg/ml had a value of p>0.05 which means that there were no differences between groups in inhibiting angiogenesis. Based on the results of the study it can be concluded that the ethanol extract of robusta coffee beans (C. robusta) 6000 μg/ml, 5500 μg/ml, and 5000 μg/ml has antiangiogenesis effect on Chorio Allantoic Membrane (CAM) of chicken embryo.
The Effectiveness of Ethanol Extract Gel of Cumin Leaves (Plectranthus Amboinicus) toward White Male Rat (Rattus Novergicus) Alyidrus, Rugayyah; Alydrus, Nur Laela; Wahyuni, Wahyuni; Awaluddin, Nurhikma; Tangden, Nopianti
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

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Abstract

The leavers of white cumin (Plectranthus amboinicus) are a species of the family. Lamiaceae, previously known as Coleus amboinicus, contains quertesin compounds that are effective in healing wounds. The purpose of this study was to determine the extract of the leaves of white cumin (Plecranthus amboinicus) can be formulated for gel readiness and can affect the healing of cuts in white male rats (Rattus novergicus). The research method was laboratory experimental with the One Group Pretest- posttest research design. The leaves of white cumin (Plectranthus amboinicus) were extracted using 96% ethanol by maceration process and made into a gel form with a concentration of 3%, 5 %, and 7%. Evaluation of the physical and chemical stability of the gel before and after the cycling test for 6 cycles. This study used 15 male white rats divided into 5 groups, each group consisting of 3 and wounded with a depth of 2 cm and a length of 3 cm. the first male white rats were given a gel concentration of 3 %, the second 5%, the third 7 %, the fourth was given a gel without extract (negative control) and fifth was given 10 of octenilin gel (positive control). The incision length was measured on day 1,3,6,9,11,13 then data analysis used the ANOVA and SPSS 22 version. The results showed that leavers of white cumin (Plectranthus amboinicus) extract was p˂ 0,05, so there was a significant difference between each treatment. It can be concluded that gel readiness can be formulated and can affect wound healing in white male rats (Rattus novergicus).
Formulation and Activity Test Of Oil Spray Deodorant Preparations In Black Cumin Seeds (Nigella Sativa L.) Against Staphylococcus Epidermidis Causes Of Body Odor Alyidrus, Rugayyah; Ramadhani, Rezki; Santi, Elvira; Awaluddin, Nurhikma; Alydrus, Nur Laela
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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Abstract

Staphylococcus epidermidis bacteria are able to convert amino acids into isovaleric acid which causes unpleasant odors. This research aims to determine whether the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray physically stable and it has activity against Staphylococcus epidermidis which causes body odor. The research method was laboratory experimental using water distillation to extract essential oils and formulate deodorant spray preparations with concentrations of F1 (1%), F2 (3%), and F3 (5%). Evaluation of preparations includes organoleptic tests, homogeneity tests, pH tests, viscosity tests, spray pattern tests, dry time tests, emulsion type tests, irritation and hedonic tests, stability tests and antibacterial activity tests of preparations. The results of the research showed that the evaluation of the deodorant spray preparation of essential oil of black cumin seeds (Nigella sativa L.) had a P value of >0.05 so that this preparation was physically stable, while the statistical results of the antibacterial activity test obtained a P value of <0.05 indicating that there was a significant difference. This preparation has different activity diameters, including F1 (1%) in the medium category at 8.47 mm, F2 (3%) and F3 (5%) in the strong category with activity above 10-20 mm. It was concluded that the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray that is physically stable and has activity against Staphylococcus epidermidis which causes body odor
Co-Authors Alydrus, Nur Laela Muhammad Yusuf Nurhikma Awaluddin Ramadhani, Rezki Santi, Elvira Tangden, Nopianti wahyuni wahyuni