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All Journal Archives of The Medicine and Case Reports Jurnal EduHealth Journal of Social Research Journal of Health, Education, Economics, Science, and Technology (J-HEST)
Alydrus, Nur Laela
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Prevalence of Enterotoxigenic Escherichia coli -LT Gene Expression in Pediatric Diarrhea Patients in Makassar City, Indonesia: A Cross-Sectional Study Alydrus, Nur Laela; Ka’bah; Kasmuddin; Prelly Loupatti
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.612

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease worldwide, particularly in children. The heat-labile toxin (LT) is a crucial virulence factor encoded by the LT gene. This study investigated the prevalence of ETEC LT gene expression in children with diarrhea in Makassar City, Indonesia. A cross-sectional study was conducted from January 2023 to December 2023. Rectal swabs were collected from children under five years of age presenting with diarrhea at outpatient clinics in Makassar. DNA was extracted, and the presence of the ETEC LT gene was detected using polymerase chain reaction (PCR). Demographic and clinical data were collected via questionnaires. The ETEC LT gene was detected in 81 (18%) children. The prevalence was significantly higher in children under one year of age (51%) compared to older age groups. ETEC LT positive children were more likely to experience vomiting and fever. ETEC expressing the LT gene contributes to a significant proportion of pediatric diarrhea cases in Makassar. The higher prevalence in younger children highlights the vulnerability of this age group. These findings emphasize the need for improved sanitation and hygiene practices to reduce ETEC transmission.
Perbandingan Metode Mikroskopik dan Rapid Diagnostic Test Deteksi Plasmodium Penderita Malaria di Kota Ambon Alydrus, Nur Laela; Ka’bah, Ka’bah; Marlin, Marlin
Journal of Health, Education, Economics, Science, and Technology (J-HEST) Vol. 3 No. 1 (2020): Journal of Health, Education, Economics, Science, and Technology
Publisher : Journal of Health, Education, Economics, Science, and Technology (J-HEST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36339/

Abstract

Malaria merupakan penyakit yang disebabkan oleh infeksi protozoa dari genus plasmodium dan merupakan salah satu masalah kesehatan masyarakat utama di seluruh dunia. Penegakkan diagnostik kasus malaria harus dilakukan berbasis laboratorium, menggunakan mikroskop atau Rapid Diagnostic Test (RDT). Gold standard untuk diagnosis malaria adalah dengan pemeriksaan mikroskopis. Rapid Diagnosis Test (RDT) merupakan salah satu alat diagnostik alternatif dalam mendeteksi Plasmodium secara cepat dan tidak memerlukan keterampilan khusus. Tujuan dari penelitian ini yaitu untuk mendapatkan perbandingan hasil deteksi plasmodium dengan metode pemeriksaan mikroskopik dan teknik Rapid Diagnostic Test (RDT). Penelitian ini merupakan penelitian deskriptif dengan jumlah sampel sebanyak 20 sampel dengan hasil yaitu 3 sampel positif dan 17 sampel negatif, dan memperoleh nilai sensitivitas sebesar 100%, spesifitas 100%. Kesimpulan pada penelitian ini yaitu pemeriksaan Rapid Diagnostic Test (RDT) menunjukan efektifitas dan kecepatan dalam mendiagnosis malaria yang cukup baik, hampir sama dengan pemeriksaan mikroskopik yang menjadi gold standar.
Anti-Inflammatory Gel Preparation From Srikaya Leaf Extract (Annona Squamosa L.) In Male White Rats (Rattus Norvegicus) Alyidrus, Rugayyah; Abbas, Reky; Junita, Nurfitria; T, Ummu Kalsum; Alydrus, Nur Laela
Journal of Social Research Vol. 4 No. 7 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i7.2650

Abstract

Soursop leaves (Annona squamosa L.) contain flavonoids whice work by inhibiting the cyclooxygenase enzyme whice occurs in inflammation, an anti-inflammatory drug agent whice works against the process of inflammation or onflammation, the body’s response to tissue damage caused by physical trauma, chemical substances and microbiology which can be characterized by redness, heat, pain, swelling. This study was conducted to determine whether the ethanol extract of soursop leaves (Annona squamosa L.) can be used as a gel preparation that is stable against chemical physics and to determine whether the gel preparation can provide anti inflammatory effects on male white rat (Rattus norvegicus). The method used in this study was a laboratory experiment, with soursop leaves extracted in the maseration method using 96% ethanol solvent, then formulated in a gel preparation with a concentration of 5 %, 6 %, 7 % follewed by evaluation of the organoleptic test preparation, pH, spreadability, viscosity or cycling test and anti inflammatory test using yhe 1 % carrageenan induction method using 15 rats. The results of the anti inflammatory test, the soursop leaf extract gela preparation in male white rats met teha stability of the gel preparation and the anti inflammatory test obtained a significant value (p>0.05) where at a concentration of 5 % it already had an anti inflammatory effect. Ethanol extract of soursop leaves can be made into a gel preparation that is physically and chemically stable and can provide anti inflamatory effectiveness in male shite mice.
The Effectiveness of Ethanol Extract Gel of Cumin Leaves (Plectranthus Amboinicus) toward White Male Rat (Rattus Novergicus) Alyidrus, Rugayyah; Alydrus, Nur Laela; Wahyuni, Wahyuni; Awaluddin, Nurhikma; Tangden, Nopianti
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.53 KB)

Abstract

The leavers of white cumin (Plectranthus amboinicus) are a species of the family. Lamiaceae, previously known as Coleus amboinicus, contains quertesin compounds that are effective in healing wounds. The purpose of this study was to determine the extract of the leaves of white cumin (Plecranthus amboinicus) can be formulated for gel readiness and can affect the healing of cuts in white male rats (Rattus novergicus). The research method was laboratory experimental with the One Group Pretest- posttest research design. The leaves of white cumin (Plectranthus amboinicus) were extracted using 96% ethanol by maceration process and made into a gel form with a concentration of 3%, 5 %, and 7%. Evaluation of the physical and chemical stability of the gel before and after the cycling test for 6 cycles. This study used 15 male white rats divided into 5 groups, each group consisting of 3 and wounded with a depth of 2 cm and a length of 3 cm. the first male white rats were given a gel concentration of 3 %, the second 5%, the third 7 %, the fourth was given a gel without extract (negative control) and fifth was given 10 of octenilin gel (positive control). The incision length was measured on day 1,3,6,9,11,13 then data analysis used the ANOVA and SPSS 22 version. The results showed that leavers of white cumin (Plectranthus amboinicus) extract was p˂ 0,05, so there was a significant difference between each treatment. It can be concluded that gel readiness can be formulated and can affect wound healing in white male rats (Rattus novergicus).
Formulation and Activity Test Of Oil Spray Deodorant Preparations In Black Cumin Seeds (Nigella Sativa L.) Against Staphylococcus Epidermidis Causes Of Body Odor Alyidrus, Rugayyah; Ramadhani, Rezki; Santi, Elvira; Awaluddin, Nurhikma; Alydrus, Nur Laela
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Staphylococcus epidermidis bacteria are able to convert amino acids into isovaleric acid which causes unpleasant odors. This research aims to determine whether the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray physically stable and it has activity against Staphylococcus epidermidis which causes body odor. The research method was laboratory experimental using water distillation to extract essential oils and formulate deodorant spray preparations with concentrations of F1 (1%), F2 (3%), and F3 (5%). Evaluation of preparations includes organoleptic tests, homogeneity tests, pH tests, viscosity tests, spray pattern tests, dry time tests, emulsion type tests, irritation and hedonic tests, stability tests and antibacterial activity tests of preparations. The results of the research showed that the evaluation of the deodorant spray preparation of essential oil of black cumin seeds (Nigella sativa L.) had a P value of >0.05 so that this preparation was physically stable, while the statistical results of the antibacterial activity test obtained a P value of <0.05 indicating that there was a significant difference. This preparation has different activity diameters, including F1 (1%) in the medium category at 8.47 mm, F2 (3%) and F3 (5%) in the strong category with activity above 10-20 mm. It was concluded that the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray that is physically stable and has activity against Staphylococcus epidermidis which causes body odor
Co-Authors Abbas, Reky Alyidrus, Rugayyah Junita, Nurfitria Kasmuddin Ka’bah Ka’bah, Ka’bah Marlin, Marlin Nurhikma Awaluddin Prelly Loupatti Ramadhani, Rezki Santi, Elvira T, Ummu Kalsum Tangden, Nopianti wahyuni wahyuni