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Primadana, Aditya
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Health Professions Nursing

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Hubungan Inflammatory Bowel Disease sebagai Risiko terjadinya Penyakit Parkinson Sugondo, Alexander Tikara; Artama, Marvell Aurelinus; Primadana, Aditya; Savitri, Kania Aviandi; Ayunani, Nadia Noorbertha
Jurnal Keperawatan Vol 16 No 2 (2024): Jurnal Keperawatan: Juni 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v16i2.1714

Abstract

Parkinson’s disease (PD) adalah penyakit neurodegeneratif yang menyebabkan gangguan gerakan dengan prevalensi yang diperkirakan akan terus meningkat. Beberapa penelitian menunjukkan bahwa inflammatory bowel disease (IBD) dapat menjadi faktor risiko terjadinya PD. Memaparkan dan menganalisis hubungan antara IBD sebagai faktor risiko terjadinya PD. Penelusuran literatur dilakukan melalui Google Scholar, PubMed, SAGE, JSTOR, ProQuest, dan EBSCOhost, dengan kata kunci “inflammatory bowel disease”, “Parkinson’s disease”, dan “chronic intestinal inflammation”. Kriteria inklusi mencakup literatur orisinil dalam Bahasa Inggris yang meneliti hubungan IBD dengan PD. Pada studi ini didapatkan bahwa ditemukan hubungan antara IBD dan PD. Peningkatan risiko PD pada pasien dengan IBD dapat terkait dengan mekanisme inflamasi, gangguan gut-brain axis, penumpukan protein α-synuclein, dan mutasi gen LRRK2. Terapi antiinflamasi dapat digunakan untuk mencegah terjadinya PD pada pasien IBD. Sebagian besar studi menunjukkan adanya hubungan yang signifikan antara IBD dan PD.
EOSINOPHILIA AS A PREDICTOR MORBIDITY OF SOIL- TRANSMITTED HELMINTHIASES AMONG WIDODAREN PLANTATION WORKERS IN JEMBER Primadana, Aditya; Nurdian, Yudha; Agustina, Dini; Hermansyah, Bagus; Armiyanti, Yunita
Journal of Vocational Health Studies Vol. 3 No. 2 (2019): November 2019 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.887 KB) | DOI: 10.20473/jvhs.V3.I2.2019.47-52

Abstract

Background: Helminthiasis is a neglected tropical disease and still remain a health problem in tropical and sub-tropical countries, including Indonesia. According to WHO, approximately 1,5 billion people or 24% of the world's population, are infected with Soil-Transmitted Helminth (STH). Morbidity is directly related to the intensity of STH infestation. Some of the studies shown a significant correlation between eosinophilia and helminthiasis. Eosinophilia on the blood smear examination may be used as a marker of STH infestation. Purpose: to determine the correlation between Soil-Transmitted Helminthiases and eosinophilia as a predictor of morbidity of STH infestation among Widodaren Plantation Workers in Jember. Method: This observational analytical study use the Kato-Katz method to determine infestation of STH and its intensity measured by egg count per gram stool (EPG). Blood smear examination stained with Giemsa conduct to determine eosinophil count. Result: Prevalence of STH infestation was 22,7% (15/66). Ascaris lumbricoides infection was 13,6% (9/66) and Hookworm infection was 4,5% (3/66). There is mixed infection between A. lumbricoides and Hookworm, the prevalence was 4,5%% (3/66). All of the infection intensity was light. The prevalence of eosinophilia was 27,2% (18/66). There was a significant correlation between STH infection and eosinophilia (P=0,000) but, there was a very weak correlation between the intensity of STH infection and eosinophilia (r=0,281; p=0,258). Conclusion: The prevalence of STH infection among Widodaren Plantation Workers is 22,7% and predominated by A. lumbriocides. There is a positive correlation between intensity of STH infection and eosinophilia as predictor morbidity of STH infection with very weak power.
Co-Authors Artama, Marvell Aurelinus Ayunani, Nadia Noorbertha Bagus Hermansyah Dini Agustina Savitri, Kania Aviandi Sugondo, Alexander Tikara Yudha Nurdian Yunita Armiyanti