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Peranan Madu 15% Terhadap Peningkatan pH Saliva Wanita Menopause Syahrul, Dwis; Dewi, Tri Purnami; Sulistyawati, I G A P Oka
Interdental: Jurnal Kedokteran Gigi Vol 13 No 1 (2017): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v13i1.354

Fructose, which is the highest concentration of substance in honey, can stimulate saliva more than sucrose, so it is considered to affect the acidity (pH) of saliva, especially postmenopausal women who generally experience a decrease in salivary pH. This study aims to determine the ratio of salivary pH of menopausal women who rinse with drinking water and rinse with 15% concentrated honey. A sample of 32 postmenopausal women between the ages of 50-60 years were divided into 2 groups, namely the control group and the treatment group. Before being treated, the initial salivary pH of the two groups was recorded. Then the control group was instructed to rinse with drinking water and the treatment group was instructed to rinse with 15% honey. Both groups rinsed at the same time for 3 minutes. Then the salivary pH of each group is measured. Data analyzed by independent t-test between the two groups, showed a significance value of 0.037 in the control group and 0.041 in the treatment group (p <0.05). Paired t-test conducted in each group produced a significance value of 0.164 for the control group and 0.07 for the treatment group (p <0.05). Gargling with honey 15% can significantly increase the salivary pH of menopausal women compared to gargling with drinking water.

Peranan Madu 15% Terhadap Peningkatan pH Saliva Wanita Menopause Dwis Syahrul; Tri Purnami Dewi; I G A P Oka Sulistyawati
Interdental: Jurnal Kedokteran Gigi Vol. 13 No. 1 (2017): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v13i1.354

Fructose, which is the highest concentration of substance in honey, can stimulate saliva more than sucrose, so it is considered to affect the acidity (pH) of saliva, especially postmenopausal women who generally experience a decrease in salivary pH. This study aims to determine the ratio of salivary pH of menopausal women who rinse with drinking water and rinse with 15% concentrated honey. A sample of 32 postmenopausal women between the ages of 50-60 years were divided into 2 groups, namely the control group and the treatment group. Before being treated, the initial salivary pH of the two groups was recorded. Then the control group was instructed to rinse with drinking water and the treatment group was instructed to rinse with 15% honey. Both groups rinsed at the same time for 3 minutes. Then the salivary pH of each group is measured. Data analyzed by independent t-test between the two groups, showed a significance value of 0.037 in the control group and 0.041 in the treatment group (p <0.05). Paired t-test conducted in each group produced a significance value of 0.164 for the control group and 0.07 for the treatment group (p <0.05). Gargling with honey 15% can significantly increase the salivary pH of menopausal women compared to gargling with drinking water.

Antifungal Potential of Sansevieria Trifasciata Infusion as a Cleaner for Dentures Dewi, Tri Purnami; Nurlitasari, Dewi Farida; Putra, Bagus Eda Purnariyawan
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.12202

Introduction: Thermoplastic nylon is one of the alternative materials used for denture bases, in addition to acrylic resin. It offers good flexibility and aesthetics; however, its high water absorption makes it susceptible to microbial colonization. Sansevieria trifasciata is a herbal plant known for its antiseptic, antibacterial, and antifungal properties. Therefore, it has the potential to be developed as a natural denture cleanser. This study aims to determine the antifungal effect of a 40% S. trifasciata var. laurentii infusion on the growth of Candida albicans colonies on thermoplastic nylon denture base plates. Material And Methods: This in vitro experimental study used a post-test only control group design with four groups: one negative control (sterile distilled water) and three groups treated with 40% S. trifasciata infusion for 24, 48, and 72 hours. A Candida albicans suspension (1.5 × 10⁸ CFU/mL) was prepared using McFarland standard 0.5. Phytochemical screening was conducted to identify active compounds in the extract. Data were analyzed using One-Way ANOVA and LSD post hoc test (p < 0.05). Results and Discussions: Phytochemical analysis of the S. trifasciata var. laurentii extract indicated the presence of saponins, phenols, flavonoids, and alkaloids, all of which are known to exhibit antifungal activity. The descriptive analysis showed that the treatment group with 72-hour immersion had the lowest average colony count of C. albicans. Statistical analysis using One-Way ANOVA showed a significant difference among the groups (p = 0.001). LSD post hoc analysis revealed that all treatment groups differed significantly from the control group (p < 0.05). These results indicate that prolonged immersion in S. trifasciata var. laurentii infusion enhances its antifungal efficacy. The observed antifungal activity is likely related to the disruption of fungal cell membranes by the active compounds present in the extract. Conclusion: The 40% S. trifasciata var. laurentii infusion is effective in inhibiting the growth of C. albicans on thermoplastic nylon denture base plates. The most significant antifungal effect was observed with a 72-hour immersion duration.

Effectiveness of Catharanthus roseus L. extract gel on TNF-α and IL-1β in the healing process of oral lesions Dewi, Tri Purnami; Canisca Putri, Ni Putu Ayu Mas Mitha; Mertayasa, Dewa Kadek
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.105363

The global incidence of oral lesions ranges from 5% to 66%, with an average of 20%. To date, no scientific research has investigated the effects of Catharanthus roseus L. (tapak dara) leaf extract on the expression of proinflammatory cytokines in oral lesion healing. This study aimed to evaluate the effectiveness of tapak dara leaf extract gel in reducing the expression of the proinflammatory cytokines TNF-α and IL-1β during oral lesion healing. A total of 30 mice (Mus musculus) were divided into five groups: four treatment groups and one control group, each housed separately. The gel formulation was prepared by mixing diluted extract solutions (5%, 10%, and 20%) into a 2% CMC-Na solution, heated and stirred for 10 minutes, and then cooled to achieve a gel consistency. Phytochemical screening was performed to qualitatively identify flavonoids, tannins, saponins, phenolics, alkaloids, steroids, and terpenoids. Expression levels of TNF-α and IL-1β were measured using an ELISA kit. ANOVA results showed that tapak dara leaf extract gel at 5%, 10%, and 20% significantly reduced TNF-α and IL-1β expression (p = 0.001). Tukey’s post hoc test indicated that the positive control (K+) group had the lowest expression of both TNF-α and IL-1β compared to other groups (p = 0.001). In conclusion, tapak dara leaf extract gel effectively reduces TNF-α and IL-1β expression, supporting its potential role in the healing process of oral lesions.

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