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All Journal The Indonesian Biomedical Journal Cermin Dunia Kedokteran
Mikhael, Rodry
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Profil Fibrilasi Atrium di RSUD Kabupaten Belitung Timur tahun 2014-2016 Dharmawan, Melissa; Mikhael, Rodry; Marthadinata, Felicity; Lustoyo, Lidya; Kawengian, Christian
Cermin Dunia Kedokteran Vol 44, No 9 (2017): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (864.601 KB) | DOI: 10.55175/cdk.v44i9.723

Abstract

Latar Belakang. Atrial Fibrilasi (AF) merupakan aritmia yang paling sering ditemukan. Data epidemiologis profil pasien AF di rumah sakit tipe D di Indonesia masih kurang. Tujuan. Menyediakan data epidemiologis pasien AF di RSUD Kab. Belitung Timur 2014-2016. Metode. Penelitian berbasis rekam medis pasien AF yang dirawat inap di RSUD Kab. Belitung Timur selama tahun 2014-2016. Variabel yang dihimpun meliputi karakteristik sosiodemografi, komorbid, elektrokardiogram, terapi antiaritmia, angka mortalitas. Hasil.Terdapat 69 kasus AF rawat inap dari tahun 2014-2016; 35 orang (50,7%) laki-laki dan 34 orang (49,3%) perempuan, mayoritas (36,2%) berumur 60-75 tahun. Keluhan utama yang paling sering adalah sesak napas (59,4%), penurunan kesadaran (13,9%), dan berdebar-debar (8,7%). Mayoritas (55,1%) menderita AF respon ventrikel cepat. Didapatkan juga hipertensi (76,8%), gagal jantung (73,9%), infeksi akut (42%), penyakit serebrovaskuler (11,6%), penyakit ginjal kronis (10,1%), anemia (8,7%), Diabetes Mellitus tipe 2 (7,2%), dan penyakit hipertiroid (2,9%). Obat yang paling sering digunakan (39,1%) adalah kombinasi bisoprolol dan digoxin. Angka kematian dalam rumah sakit akibat semua penyebab sebesar 15,9%.Background. Atrial Fibrillation (AF) is the most common arrhythmia encountered in clinical practice. There is lack of epidemiological data on AF patient profile in rural hospital in Indonesia. Purpose. To provide epidemiological data of hospitalized AF patient in RSUD Belitung Timur from 2014 to 2016. Methods. Review of medical records of AF patients in RSUD Belitung Timur from 2014-2016. Relevant variables such as demographic and clinical characteristics, electrocardiogram, antiarrhytmia therapy and mortality rate were documented. Results. Sixty nine cases of atrial fibrillation from 2014-2016 were analyzed. There were 35 (50.7%) male dan 34 (49.3%) female, majority (36.2%) were 60-75 years old. The most common main symptoms were dyspnea (59.4%), loss of consciousness (13.9%) and palpitation (8.7%). Most patients (55.1%) had Rapid Ventricular Response. They also had hypertension (76.8%), heart failure (73.9%), acute infections (42%), cerebrovascular disease (11.6%), chronic kidney disease (10.1%), anemia (8.7%), type 2 Diabetes Mellitus (7.2%) and Hyperthyroid disease (2.9%). The most common (39.1%) antiarrhytmic used was combination of bisoprolol and digoxin. In-hospital all-cause mortality rate was 15.9%.
Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis Partan, Radiyati Umi; Mikhael, Rodry; Adinata, Triawan; Darma, Surya; Reagan, Muhammad; Kriswiastiny, Rina; Kusnadi, Yulianto; Salim, Eddy Mart
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2085

Abstract

BACKGROUND: Vitamin D has a role in downregulating the proinflammatory cytokines as well as promoting the antiinflammatory pathway in rheumatoid arthritis (RA). Seluang fish (Rasbora sp.) has potency as a new source of vitamin D. Previous study had proven Seluang fish oil efficacy in systemic lupus erythematosus. However, there are no trials that prove its efficacy in RA yet. Hence, this study was conducted to find out the ability of Seluang fish oil to improve proinflammatory cytokines, vitamin D levels, and disease activity in RA.METHODS: A clinical trial with a randomized and double-blind method was done in two groups, each one consisting of 17 RA subjects. One group was given 500 mL of a Seluang fish oil capsule (contains 665 IU cholecalciferol), while the other group was given a placebo daily, for 12 consecutive weeks. Measurements of the RA disease activity score 28 erythrocyte sedimentation rate (DAS28-ESR) and DAS28 C-reactive protein (DAS28-CRP), as well as measurement of interleukin (IL)-6, IL-17, and vitamin D levels by using immunoassay method were performed before and after the supplementation.RESULTS: Significant alterations in the lower levels of IL-17 were observed in the Seluang fish oil group (p=0.031), but not in the placebo group (p=0.320). Reduction of DAS28-ESR (p=0.000) and DAS28-CRP (p=0.000) score demonstrated that the Seluang fish oil supplementation was useful in reducing RA disease activity. No significant shift was observed in either vitamin D (p=0.967) or IL-6 levels (p=0.076) after Seluang Fish Oil supplementation.CONCLUSION: Seluang fish oil is effective in lowering IL-17 levels, DAS28-ESR, and DAS28-CRP, but not in improving vitamin D level or lowering IL-6 level in RA patients.KEYWORDS: rheumatoid arthritis, seluang fish oil, interleukin-6, interleukin-17, vitamin D, DAS28
Co-Authors Adinata, Triawan Dharmawan, Melissa Eddy Mart Salim, Eddy Mart Kawengian, Christian Kriswiastiny, Rina Lustoyo, Lidya Marthadinata, Felicity Muhammad Reagan Radiyati Umi Partan, Radiyati Umi Surya Darma Yulianto kusnadi