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Manifestasi klinis dan derajat aktivitas penyakit pada penyandang Lupus Eritematosus Sitemik di Rumah Sakit Dr. Mohammad Hoesin Palembang Partan, Radiyati Umi; Hermansyah, Hermansyah; Darma, Surya; Reagan, Muhammad; Muthia, Putri; Salim, Eddy Mart; Kriswiastiny, Rina; Kurniati, Nova; Yuniza, Yuniza; Silitonga, Aira Priamas
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 1 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I1.110

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can affect various organs. Clinical manifestations vary from mild to severe depending on the organs involved. Manifestations of SLE in the kidney known as lupus nephritis can occur in 60% of the SLE population and are more common in Asian, Hispanic, Native American, and Black populations, especially in women of childbearing age, involvement of other organs such as neurology is referred to as neuropsychiatric lupus, as well as other organs can manifest such as mucocutaneous lupus, arthritis, pericarditis and other organs. This community service is carried out as a form of preventive treatment with counseling methods to increase knowledge and health checks for early detection of SLE, as well as promotive efforts for the SLE community in the disease polyclinic at Dr. Mohammad Hoesin Palembang, South Sumatra which is one of the teaching hospitals of the Faculty of Medicine, Sriwijaya University. This activity was attended by 35 people with SLE with several risk facts such as female gender and middle adulthood which is quite common, and some of the systemic clinical manifestations experienced are almost fatigue and fever, for musculoskeletal manifestations the most commonly experienced is arthritis, while the most common manifestations of other organs are mucocutaneous disorders. Keywords: Lupus, Autoimmune, Disease Activity
Hubungan Status Gizi dan Asupan Energi-Protein dengan Pertambahan Berat Badan Selama Hamil sebagai Risiko Maternal Kurniati, Ardesy Melizah; Partan, Radiyati Umi; Lestari, Peby Maulina; Liberty, Iche Andriyani
Bahasa Indonesia Vol 23 No 1 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i1.5409

Abstract

Pendahuluan: Pertambahan berat badan selama kehamilan yang ideal diharapkan dapat mendukung persalinan yang aman. Status gizi ibu prakehamilan menjadi acuan dalam menentukan pertambahan berat badan yang ideal di setiap trimester kehamilan. Asupan gizi yang adekuat, terutama asupan energi dan protein, diharapkan dapat memenuhi kebutuhan ini. Status gizi prakehamilan dan asupan gizi yang tidak mencukupi merupakan risiko maternal yang harus dipantau. Penelitian ini memiliki tujuan utama untuk menganalisis hubungan antara status gizi ibu prakehamilan dan asupan energi-protein dengan pertambahan berat badan pada ibu hamil di Kecamatan Gandus. Metode: Penelitian ini memiliki desain cross-sectional menggunakan data primer. Ibu hamil trimester 2 dan 3 dengan kehamilan janin tunggal yang menghadiri kegiatan skrining kesehatan di Balai Kecamatan Gandus Palembang, memiliki data berat badan sebelum hamil, dan bersedia berpatisipasi direkrut sebagai responden penelitian. Responden menjalani pengukuran antropometri dan wawancara asupan energi-protein 1 bulan terakhir menggunakan formulir SQ-FFQ. Data dianalisis menggunakan Chi-Square (alternatif Fisher/Kolmogorov-Smirnov). Hasil: Sebanyak enam puluh ibu hamil berpartisipasi, sebagian besar berada pada rentang usia reproduktif, masa kehamilan trimester 3, dan beraktivitas sebagai ibu rumah tangga. Status gizi sebelum hamil sebagain besar berada pada berat badan lebih/obes dan tidak ditemukan status gizi kurang. Pertambahan berat badan ibu sebagian besar tidak memenuhi rekomendasi, demikian pula dengan asupan energi-protein. Terdapat hubungan bermakna antara status gizi prakehamilan dan pertambahan berat badan selama hamil (p=0,014). Tidak terdapat hubungan antara asupan energi maupun protein dengan pertambahan berat badan selama hamil. Simpulan: Status gizi prakehamilan berhubungan dengan pertambahan berat badan selama hamil, sebaliknya asupan energi-protein tidak berhubungan.
Diagnosis of Osteogenesis Imperfecta in 23 Years Old Man: A Case Report Partan, Radiyati Umi; Hafizzanovian; Desi Oktariana
Jurnal RSMH Palembang Vol. 3 No. 1 (2022): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v3i2.34

Abstract

Osteogenesis imperfecta is a disorder of the formation of collagen tissue that functions as connective tissue and is caused by a gene mutation that causes disturbances in the formation of type 1 collagen. This study aimed to describe the diagnosis of osteogenesis imperfecta. A 23-year-old man came to the rheumatology polyclinic of Dr. Mohammad Hoesin General Hospital Palembang with a complaint of recurrent fractures since ± 17 years ago. The patient also complained that the hearing in the left ear was slowly decreasing. The patient's right thigh was still pinned 2 years ago, but after being controlled by orthopedics, it was said that the bones were still not fused. Then the patient was referred to the rheumatology polyclinic for further examination and management. On examination, the patient was 145 cm tall and weighed 40 kg. He had blue-gray sclera, triangular facial appearance, right leg length 86 cm, left leg length 78 cm, blue sclera, and scoliosis, while secondary sex growth was within normal limits. From the examinations of bone survey and bone age, it was found osteoporotic bone structure, scoliosis, plate-screw in the middle 1/3 of the right femur, fracture union of the femur, bowing of the left femur, BMD Z-Score -3.0 means very low compared to the same age and gender. Management is more focused on supportive therapy with the aim of minimizing the occurrence of fractures, minimizing disability, and helping people with osteogenesis imperfecta to be independent and maintain overall health. The goal of orthopedic management is to treat osteogenesis imperfecta with fractures and prevent or correct bone deformity. In conclusion, osteogenesis imperfecta is a complex hereditary disease characterized by striking clinical variability necessitating a logical classification system. Disease management requires multidisciplinary experts and further research on therapeutic approaches such as bisphosphonates.
The deep convolutional networks for the classification of multi-class arrhythmia Akbar, Muhamad; Nurmaini, Siti; Partan, Radiyati Umi
Bulletin of Electrical Engineering and Informatics Vol 13, No 2: April 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/eei.v13i2.6102

Abstract

An arrhythmia is an irregular heartbeat. Many researchers in the AI field have carried out the automatic classification of arrhythmias, and the issue that has been widely discussed is imbalanced data. A popular technique for overcoming this problem is the synthetic minority oversampling technique (SMOTE) technique. In this paper, the author adds some sampling of data obtained from other datasets into the primary dataset. In this case, the main dataset is the Massachusetts Institute of Technology–Beth Israel Hospital (MIT-BIH) arrhythmia database and an additional dataset from the MIT-BIH supraventricular arrhythmia database. The classification process is carried out with one-dimensional convolutional neural network model (1D-CNN) to perform multiclass and subject-class advancement of medical instrumentation (AAMII) classifications. The results obtained from this study are an accuracy of 99.10% for multiclass and 99.25% for subject-class.
Correlation between Vitamin D and Hemoglobin Levels in Anemia during Pregnancy Sari, Sagita Darma; Partan, Radiyati Umi; Lestari, Peby Maulina; Liberty, Iche Andriyani
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 6: JUNE 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i6.7310

Abstract

Introduction: Anemia in pregnancy is a serious health problem for pregnant women that can increase the risk of postpartum hemorrhage, low birth weight, and fetal growth retardation. Low intake of foods that are sources of vitamin D causes low concentrations of vitamin D (25 Hydroxyvitamin D), which can increase hepcidin expression, thereby disrupting iron hemostasis which ultimately causes anemia in pregnant women. This study aims to determine the correlation between vitamin D levels and hemoglobin in anemia in pregnancy. Methods: This study used a case-control design with 68 pregnant women as respondents. Vitamin D levels were examined using 25 (OH) D levels and the ELFA method. Data on age, body mass index (BMI), frequency of pregnancy, education, and frequency of antenatal care visits were analyzed using the chi-square test and logistic regression analysis. Results: The results of the study show that the most significant proportion occurred in the age range of 20 – 35 years (84.5%), the majority of respondents had a normal body mass index (60.3%), respondents with a pregnancy frequency of 1-3 were 86.8%, most respondents had secondary education (63.2%), respondents who had regular prenatal visits amounted to 86.8%, the majority of respondent had a vitamin d insufficiency levels (48.5%). Bivariate analysis show revealed that significant influencing factors of anemia pregnancy were age (p=0.008), BMI (p=0.040), and frequency of ANC (p=0.012). There is no correlation between hemoglobin levels and vitamin D (p=0.707). Conclusion: This study did not correlate vitamin D levels and hemoglobin levels.
THE RELATIONSHIP OF THE CHARACTERISTICS OF ANTI-EPILEPSY DRUGS WITH THE C OGNITIVE FUNCTION OF EPILEPSY PATIENTS Handayani, Sri; Partan, Radiyati Umi; Hafy, Zen; Octaviana, Fitri; Harun, Yusril; Bahar, Erial; Lestari, Nova
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.02

Abstract

Background: One of the side effects of the use of antiepileptic drugs (AEDs) is cognitive disorder. Several studies show a relationship between the type of AEDs and cognitive disturbance in people with epilepsy. Dose-dependent side effects of AEDs have also been reported in prior research. However, there are results from different studies on different populations. Objective: This research aims to evaluate the relationship between AEDs characteristics and the cognitive function of epilepsy patients. Methods: This cross-sectional study was conducted in the Neurology Department of Dr. Mohammad Hoesin General Hospital Palembang, from 1 November 2021 to 31 March 2022. Researchers used the MoCA-Ina questionnaire to collect medical record data and conduct interviews. Results: In this research, the number of research subjects obtained was 70 people with epilepsy. Characteristics of sociodemographic sufferer Epilepsy in this study was mostly (44.3%) aged 26 – 45 years with type sex most were women (71.4%), and the majority subjects (52.9%) had level high school education. Characteristics of antiepileptic drugs consumed by people living with epilepsy: most of them, i.e., amounting to 57.1%, have consumed antiepileptic drugs for > 12 months. Most of the research subjects (64.3%) had function-impaired cognitive range MoCA-Ina scores of 8 – 30. The function most cognitively disturbed, namely in the memory domain, cancels that am, counting to 82.9%. Education level is the only variable from characteristics of sociodemographic and clinical features connected significantly to cognitive function in general (p-value 0.013). The number, duration, and type of antiepileptic drugs do not determine a significant relationship with cognitive function in general. Conclusion: There is a significant relationship between valproic acid and the number of AEDs with the naming domain, as well as between valproic acid and the duration of AEDs with the abstraction domain.
Multiclass instance segmentation optimization for fetal heart image object interpretation Syaputra, Hadi; Nurmaini, Siti; Partan, Radiyati Umi; Roseno, Muhammad Taufik
IAES International Journal of Artificial Intelligence (IJ-AI) Vol 14, No 5: October 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijai.v14.i5.pp4137-4150

Abstract

This research aims to develop a multi-class instance segmentation model for segmenting, detecting, and classifying objects in fetal heart ultrasound images derived from fetal heart ultrasound videos. Previous studies have performed object detection on fetal heart images, identifying nine anatomical classes. Further, these studies have conducted instance segmentation on fetal heart images for six anatomical classes. This research seeks to expand the scope by increasing the number of classes to ten, encompassing four main chambers left atrium (LA), right atrium (RA), left ventricle (LV), right ventricle (RV); four valves tricuspid valve (TV), pulmonary valve (PV), mitral valve (MV), and aortic valve (AV); one aorta (Ao), and the spine. By developing an instance segmentation method for segmenting ten anatomical structures of the fetal heart, this research aims to make a significant contribution to improving medical image analysis in healthcare. It also aims to pave the way for further research on fetal heart diseases using AI. The instance segmentation approach is expected to enhance the accuracy of segmenting fetal heart images and allow for more efficient identification and labeling of each anatomical structure in the fetal heart.
Correlation of Vitamin D Intake with Hemoglobin Levels in Pregnant Women Sari, Sagita Darma; Partan, Radiyati Umi; Lestari, Peby Maulina; Liberty, Iche Andriyani
Indonesian Journal of Global Health Research Vol 6 No S5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS5.4162

Abstract

Pregnancy anemia called " potential danger to mother and child " ( potential endanger mother and child ), increasing risk antepartum hemorrhage , postpartum hemorrhage and surgery caesarean emergency . In babies risky malformation Congenital and Low Birth Weight Infants . The incidence of pregnancy anemia in Indonesia is experiencing increase every year . By clinical anemia closely connection with vitamin D deficiency . Vitamin D plays a role in arrange distribution substance iron inside body . Objective: to analyze the correlation of vitamin D intake with hemoglobin levels in pregnant women. Method : Cross Sectional research design. The sample was pregnant women in the Gandus Palembang Health Center working area who were taken by consecutive sampling, totaling 91 people. Data analyzed using a simple liner regression test. Results: The average hemoglobin level in pregnant women was 11.49 gr / dl and the average vitamin D intake was 12.05 µg. Pregnant women who had sufficient vitamin D intake ≥ 15 µg were 9 people (10%). Pregnant women with hemoglobin levels ≥ 11 gr / dl as many as 58 people (63.7%). The results of the simple linear regression test obtained p value = 0.028 and R square value 0.053. Conclusion: there is a correlation between vitamin D intake and hemoglobin levels in pregnant women with the effect of vitamin D intake on hemoglobin levels of 5.3%.
Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis Partan, Radiyati Umi; Mikhael, Rodry; Adinata, Triawan; Darma, Surya; Reagan, Muhammad; Kriswiastiny, Rina; Kusnadi, Yulianto; Salim, Eddy Mart
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2085

Abstract

BACKGROUND: Vitamin D has a role in downregulating the proinflammatory cytokines as well as promoting the antiinflammatory pathway in rheumatoid arthritis (RA). Seluang fish (Rasbora sp.) has potency as a new source of vitamin D. Previous study had proven Seluang fish oil efficacy in systemic lupus erythematosus. However, there are no trials that prove its efficacy in RA yet. Hence, this study was conducted to find out the ability of Seluang fish oil to improve proinflammatory cytokines, vitamin D levels, and disease activity in RA.METHODS: A clinical trial with a randomized and double-blind method was done in two groups, each one consisting of 17 RA subjects. One group was given 500 mL of a Seluang fish oil capsule (contains 665 IU cholecalciferol), while the other group was given a placebo daily, for 12 consecutive weeks. Measurements of the RA disease activity score 28 erythrocyte sedimentation rate (DAS28-ESR) and DAS28 C-reactive protein (DAS28-CRP), as well as measurement of interleukin (IL)-6, IL-17, and vitamin D levels by using immunoassay method were performed before and after the supplementation.RESULTS: Significant alterations in the lower levels of IL-17 were observed in the Seluang fish oil group (p=0.031), but not in the placebo group (p=0.320). Reduction of DAS28-ESR (p=0.000) and DAS28-CRP (p=0.000) score demonstrated that the Seluang fish oil supplementation was useful in reducing RA disease activity. No significant shift was observed in either vitamin D (p=0.967) or IL-6 levels (p=0.076) after Seluang Fish Oil supplementation.CONCLUSION: Seluang fish oil is effective in lowering IL-17 levels, DAS28-ESR, and DAS28-CRP, but not in improving vitamin D level or lowering IL-6 level in RA patients.KEYWORDS: rheumatoid arthritis, seluang fish oil, interleukin-6, interleukin-17, vitamin D, DAS28
Vitamin D Levels in Epilepsy Patients at the Neurology Polyclinic, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Sri Handayani; Partan, Radiyati Umi; Zen Hafy; Fitri Octaviana; Citra Ananta Avis; Rini Nindela; Selly Marisdina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 12 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i12.949

Abstract

Background: In epilepsy patients, treatment is often lifelong and anti-epileptic drugs (AEDs) can be divided into two general groups, namely drugs that affect cytochrome P-450 (CYP-450) such as carbamazepine, phenytoin, primidone, or valproic acid, and those that affect minimal cytochrome P-450 such as gabapentin, vigabatrin, levetiracetam, oxcarbazepine, or topiramate. AEDs include various drugs that can cause a decrease in vitamin D levels. Therefore, this study was aimed at examining vitamin D levels in epilepsy patients who took AEDs at the neurology polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This research is a descriptive study with a cross-sectional design using primary data obtained from the results of patient examinations using laboratory tests and secondary data from medical records. Results: As many as 78% (14 subjects) who received monotherapy had vitamin D levels below normal, and 16 subjects, or 76%, who received polytherapy had vitamin D levels below normal (p = 0.907). A total of 13 (72%) subjects who received phenytoin had vitamin D levels below normal, as well as 5 (63%) subjects who received carbamazepine and 12 (92%) subjects who received other therapies (p = 0.235). A total of 12 (67%) subjects who received therapy for 1-3 years and 18 (86%) subjects who received therapy > 3 years had vitamin D levels below normal (p = 0,406). Conclusion: Vitamin D deficiency is a crucial problem in epilepsy patients receiving AED therapy, where more than 75% of patients have vitamin D deficiency. In this study, vitamin D deficiency did not have a significant relationship with the type of therapy (monotherapy or polytherapy) or the type of drug used. used, duration of therapy, and frequency of sun exposure.