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All Journal JENIUS (Jurnal Ilmiah Manajemen Sumber Daya Manusia) Journal of Health Science and Medical Therapy
Seipalla, Fenska
Unknown Affiliation
Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Organoruthenium 9E1 and APL Altered Collagen II263-272 Peptide as Therapy for Autoimmune Diseases Safruddin, Khairu Zein; Martdana, Ardhin; Seipalla, Fenska; Sosanta, Tirza
Journal of Health Science and Medical Therapy Том 1 № 02 (2023): Journal of Health Science and Medical Therapy
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jhsmt.v1i02.277

Abstract

Therapy for autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (MS) is currently available in symptom management, pain-relieving, and mitigation of disease. Currently, prescribed drugs for patients with the disease work in specific mechanisms, regardless of failure to determine the most effective medication. We use a literature review to highlight two newly examined substances: organoruthenium 9E1 and APL altered collagen II263-272 peptide, and elaborate substances mentioned above' potential to be used in rheumatoid arthritis and MS therapy. Several studies show positive effects from 9E1 and altered CII263-272 peptides on experimented mice. Altered CII263-272 peptide can elicit Th cells to produce neurotrophic factors, decrease the body amount of pro-inflammatory T cells, increase the body amount of anti-inflammatory T cells, and alleviate collagen-induced arthritis symptoms. Meanwhile, 9E1 can inhibit Mst1 kinase effectively (IC50=45nM), giving consequences of decreasing Th1 cells' cytokines, increasing Th2 cells' cytokines, decreasing body amount's IgG1 and IgG2a, slowing down EAE and collagen-induced arthritis' manifestation, increasing IL-10 and IL-4-producing T cells. Organoruthenium and altered CII263-272 peptide possess positive and multiple effects as therapies for EAE and collagen-induced arthritis, hence potential to be prescribed to patients with rheumatoid arthritis and MS. This literature review suggests further research concerning 9E1 and altered CII263-272 peptide usage in the community to examine their effectivity, side effects, and suitable dose.
The The Impact of Digitalization on Human Resource Management Practices Seipalla, Fenska; Liem, Nadia; Siregar, Deorina Roully Gratia; Martdana, Ardhin; Paramarta, Vip
Jurnal Ilmiah Sumber Daya Manusia Vol 8 No 1 (2024): JENIUS (Jurnal Ilmiah Sumber Daya Manusia)
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32493/JJSDM.v8i1.42888

Abstract

Human Resource Management (HRM) is a discipline that focuses on managing employees within an organization to achieve the company’s strategic goals. With the advent of the digital era and the Fourth Industrial Revolution, digitalization has become a significant force that has transformed various sectors, including HRM. Understanding the impact of digital transformation on HRM is important for enhancing organizational performance. This article reviews relevant literature related to the main problem addressed. The findings reveal how digital transformation in HRM enhances the efficiency and effectiveness of HR processes by streamlining employee recruitment, selection, orientation, training, and development. Technology also increases employee engagement through self-service portals and communication platforms that facilitate better collaboration and interaction, thereby boosting employee productivity. Digital engagement platforms enhance internal communication, employee satisfaction, and retention by improving interaction and feedback mechanisms. However, digitalization introduces challenges, including concerns over data security and privacy, as well as the need for HR professionals to continually adapt to new technologies. Therefore, companies must understand the potential for both success and failure in digital strategies, especially in Human Resource Management practices. This understanding is crucial for ensuring increased efficiency and competitiveness in the digital era.
Co-Authors Liem, Nadia Martdana, Ardhin Safruddin, Khairu Zein Siregar, Deorina Roully Gratia Sosanta, Tirza Vip Paramarta