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All Journal Medula Wellness And Healthy Magazine
Nasser, Ghalib Abdul
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Kunyit sebagai agen anti inflamasi Nasser, Ghalib Abdul
Wellness And Healthy Magazine Vol 2, No 1 (2020): February
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.182 KB) | DOI: 10.30604/well.79212020

Abstract

Herb plant is a famous plant and has been used since ancient times as tradisional medicine. Turmeric or curcuma is derived from the plant Curcuma longa L (Zingiberaceae). Curcumin is one of healthfull components of tumeric. Inflammation is an adaptive physiological response induced by infection and tissueinjuriesandhas complex product series by the immune system. Usually synthetic drugs are the first line of defense againt acute and chronic inflammation but has side effects which disturb gastrointestinal and cardiovascular organs. Some of reasearch has demonstrated the mechanism curcumin as an anti-inflammatory agent. Research shows curcumin is a highly pleiotropic molecule capable of interacting with numerous molecular targets involved in inflammation. Curcumin modulates the inflammatory response by down-regulating the activity of cyclooxygenase-2 (COX-2), lipoxygenase, and inducible nitric oxide synthase (iNOS) enzymes, inhibits the production of the inflammatory cytokines tumor necrosis factor-alpha (TNF-a), interleukin (IL) -1, -2, -6, -8, and -12, migration inhibitory protein, down-regulates mitogen-activated, and monocyte chemoattractant protein (MCP). However, curcumin has poor bioavailability. several strategies have been explored to improve curcumin’s bioavailability, with modulation of the delivery system.
Faktor-Faktor yang Mempengaruhi Kejadian Gangguan Muskuloskeletal (MSDs) pada Petani Tebu di Indonesia: Tinjauan Pustaka Nasser, Ghalib Abdul; Utomo, Muhammad Aditya; Winda Trijayanthi
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1698

Abstract

Musculoskeletal disorders (MSDs) are among the most common occupational health problems faced by workers in the agricultural sector, including sugarcane farmers in Indonesia. Excessive physical activity and performed without adequate ergonomic support make this group particularly vulnerable to musculoskeletal injuries. This study aims to synthesize determinant of MSDs among sugarcane farmers and to recommend targeted ergonomic strategies suitable for tropical agricultural environments through a literature review of scientific articles from relevant database. The findings indicate that MSDs are primarily influenced by repetitive work patterns, poor working posture, the use of non-ergonomic traditional tools, and adverse environmental conditions such as high temperatures and humidity. Additionally, psychosocial stress and limited access to ergonomic education and health facilities further exacerbate the condition. The review highlights the urgent need for comprehensive preventive strategies, including ergonomic interventions, occupational health education, improvements in working conditions, and psychosocial support. These efforts are essential to reduce the incidence of MSDs and enhance the occupational well-being of sugarcane farmers. The findings can guide policymakers in designing ergonomic-based agricultural health programs, especially among sugarcane farmers.
Co-Authors Utomo, Muhammad Aditya Winda Trijayanthi Utama, Winda Trijayanthi