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Irawan, Ira
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FORMULASI DAN UJI ANTIJAMUR Candida albicans KRIM EKSTRAK RIMPANG KENCUR (Kaempferiae galanga Linn.) DENGAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Irawan, Ira; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 2 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i2.220

Abstract

 Senyawa aktif yang terdapat pada rimpang kencur (Kaempferia galanga Linn.) antara lain alkaloid, flavonoid, dan tanin digunakan sebagai antijamur. Penelitian ini bertujuan untuk mengetahui pengaruh variasi asam stearat dan trietanolamin terhadap mutu fisik dan stabilitas sediaan krim dan aktivitasnya terhadap Candida albicans ATCC 10231 serta formula sediaan krim dengan mutu fisik yang paling baik dan memiliki aktivitas antijamur. Ekstrak rimpang kencur diperoleh dengan maserasi menggunakan etanol 70%, diformulasi dengan konsentrasi ekstrak 12% serta variasi asam stearat dan trietanolamin dengan perbandingan yaitu (10:7, 13:5, 16:3). Formulasi sediaan krim dilakukan dengan mencampurkan fase minyak dan fase air kemudian dilakukan mutu fisik meliputi uji organoleptis, homogenitas, daya sebar, daya lekat, pH, viskositas, dan Cycling test. Penelitian ini menggunakan metode difusi cakram untuk mengetahui aktivitas antijamur serta one way ANOVA untuk analisis staitistik. Hasil penelitian diperoleh diameter zona hambat ekstrak sebesar 13,17 mm. Variasi asam stearat dan trietanolamin berpengaruh terhadap mutu fisik dan aktivitas antijamur sediaan krim. Sediaan krim memiliki aktivitas antijamur terhadap Candida albicans ATCC 10231. Formula terbaik adalah formula 1 dengan variasi asam stearat : trietanolamin (10:7) yang memiliki mutu fisik paling baik, dengan diameter zona hambat sebesar 13,00 mm yang tergolong kuat dalam menghambat pertumbuhan jamur.
FORMULASI DAN UJI ANTIJAMUR Candida albicans KRIM EKSTRAK RIMPANG KENCUR (Kaempferiae galanga Linn.) DENGAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Irawan, Ira; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 2 (2023): Jurnal Farmasi (Journal of Pharmacy), October 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/qzxj1g27

Abstract

The active compounds contained in the rhizome of kencur (Kaempferia galanga Linn.) include alkaloids, flavonoids, and tannins which are used as antifungals. This study aims to determine the effect of variations of stearic acid and triethanolamine on the physical quality and stability of cream preparations and their activity against Candida albicans ATCC 10231 and cream formulation formulas with the best physical quality and have antifungal activity. Kencur rhizome extract was obtained by maceration using 70% ethanol and formulated with an extract concentration of 12% and variations of stearic acid and triethanolamine with a ratio of (10:7, 13:5, 16:3). The formulation of the cream preparation was carried out by mixing the oil phase and the water phase and then physical quality was carried out including organoleptic tests, homogeneity, spreadability, adhesion, pH, viscosity, and Cycling test. This study used the disc diffusion method to determine antifungal activity and one way ANOVA for statistical analysis. The results showed that the diameter of the extract inhibition zone was 13.17 mm. Variations of stearic acid and triethanolamine affect the physical quality and antifungal activity of cream preparations. Cream preparations have antifungal activity against Candida albicans ATCC 10231. The best formula is formula 1 with variations of stearic acid : triethanolamine (10:7) which has the best physical quality, with an inhibition zone diameter of 13.00 mm which is strong in inhibiting fungal growth.
Co-Authors Desi Purwaningsih Siti Aisiyah