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All Journal Jurnal Kedokteran Brawijaya Manuju : Malahayati Nursing Journal
Puteri, Agnes Ilene Suprapto
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Health Professions Medicine & Pharmacology Nursing Public Health

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Effect of Javanese Turmeric (Curcuma xanthorrhiza) Extract on Hepatitis Model of Alcohol-Induced Mice Puteri, Agnes Ilene Suprapto; Sandhika, Willy; Hasanatuludhhiyah, Nurina
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.798 KB) | DOI: 10.21776/ub.jkb.2020.031.01.8

Abstract

Alcoholic hepatitis is a common cause of non-viral hepatitis. Javanese turmeric (Curcuma xanthorrhiza) contains xanthorrhizol and curcuminoid that have antioxidant and anti-inflammatory effects. The purpose of this research was to detect the effect of Curcuma xanthorrhiza in decreasing hydropic degeneration and lymphocytes in alcohol-induced mice. This experimental research used post-test only controlled design. Randomly, 35 mice were divided into five groups. Four groups were induced by alcohol 30% of 4ml/kgBW in 10 days, and one group was normal group (negative control). Three of the four alcohol-induced groups were given Curcuma xanthorrhiza extract at doses of 42, 84, and 168 mg/kgBW in 10 days, 1 hour after alcohol induction. Mice livers were taken for Hematoxylin Eosin (HE) staining.  Hydropic degeneration and lymphocytes in the liver lobules were examined under a microscope. The statistical analysis used in this research was the Kruskal-Wallis, the Mann-Whitney test, and the Independent Sample T Test. P-value is significant if <0.05. The result of this research were all doses of Javanese turmeric extract significantly reduced hydropic degeneration. Doses of 84 and 168 mg/kgBW also reduced inflammatory lymphocytes (p<0.05). The dose of 168 mg/kgBW reduced the lymphocyte inflammation maximally. There was no significant difference between increasing Javanese turmeric dose and decreasing hydropic degeneration and lymphocytes (p>0.05). This research shows that Javanese turmeric (Curcuma xanthorrhiza) can attenuate hepatitis by decreasing hydropic degeneration and lymphocytes in alcohol-induced liver.
Spontaneous Preterm Labor During Hemodialysis In A Patient With End-Stage Renal Disease And Advanced Maternal Age: A Case Report Rachmana, Moch. Arif; Laraz, Lupita G.; Pratama, Raditya Ery; Puteri, Agnes Ilene Suprapto
Malahayati Nursing Journal Vol 7, No 11 (2025): Volume 7 Nomor 11 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i11.22863

Abstract

ABSTRACT Pregnancy in patients with ESRD is rare due to impaired fertility caused by HPO axis disruption. Nevertheless, with advancements in dialysis and maternal care, successful pregnancies have increasingly been reported. Such pregnancies, however, are considered high-risk and are often associated with complications such as preterm labor, intrauterine growth restriction, and low birth weight, particularly in patients with comorbidities like chronic hypertension and other risk factors such as AMA. A 41-year-old gravida 3 para 2 woman with ESRD secondary to chronic hypertension, undergoing routine hemodialysis twice weekly with each session lasting five hours for the past five years, presented with spontaneous preterm labor during a scheduled dialysis session. The patient began experiencing uterine contractions accompanied by a bloody show during the second hour of hemodialysis. The session was discontinued prematurely due to these symptoms. Subsequent examination revealed cervical dilation of 3 cm, confirming the onset of labor. Due to a history of menstrual irregularities, the pregnancy had been recognized relatively late, at 20 weeks of gestation. At 31 weeks, the patient delivered a live preterm infant. The neonate was born with low birth weight but responded well to immediate neonatal management and stabilization. Although pregnancy in ESRD patients presents significant risks, favorable maternal and neonatal outcomes can still be achieved. This case illustrates the importance of early detection, coordinated multidisciplinary care, and vigilant monitoring in improving perinatal outcomes in women undergoing chronic hemodialysis. Keywords: End-Stage Renal Disease, Hemodialysis, Preterm Labor, High Risk Pregnancy.
Co-Authors Laraz, Lupita G. Nurina Hasanatuludhhiyah Pratama, Raditya Ery Rachmana, Moch. Arif Willy Sandhika