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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Ophthalmologica Indonesiana
Cisca Kuswidyati
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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SELENIUM SEBAGAI TERAPI OFTALMOPATI GRAVES DERAJAT RINGAN Laura Agnestasia Djunaedi; Ferdy Iskandar; Cisca Kuswidyati
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v69i8.190

Abstract

Oftalmopati Graves (OG) merupakan manifestasi ekstra-tiroid tersering dari penyakit Graves. Sebanyak lebih dari 50% penderita Graves akan mengalami OG, bahkan 10% diantaranya menderita OG derajat berat. Mekanisme terjadinya OG berhubungan dengan reaksi autoimun yang sangat kompleks dan dicurigai juga berhubungan dengan ketidakseimbangan kadar antioksidan serta oksidan di dalam tubuh. Selain itu, faktor lingkungan (rokok) dan juga kontrol yang buruk dari penyakit Graves semakin memicu progresifitas dari oftalmopati.Salah satu komponen antioksidan yang paling banyak terdapat pada kelenjar tiroid adalah selenium. Selenium diharapkan dapat membantu mengatasi OG terutama pada derajat ringan dengan memperbaiki ketidakseimbangan antara kadar oksidan dan antioksidan di dalam tubuh. Namun, pemberian selenium tidak dapat dilakukan secara bebas karena pemberian dalam jumlah yang tidak tepat dapat memicu timbulnya beberapa jenis kanker dan juga diabetes mellitus tipe II.
Spontaneous Ocular Haemorrhage: Poster Presentation - Case Report - General practitioner Klarissa Chrishalim; Cisca Kuswidyati
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/nmkbwr34

Abstract

Introduction : Hemorrhagic complications are one of the major complications encountered with reperfusion therapies but rarely involve the ocular, especially hyphema. Case Illustration : a 61-year-old woman presented with blurred vision, discomfort, and red eye in her right eye. She had been treated for hypertension, diabetes mellitus, and coronary artery disease with antiplatelet and other oral medication for 5 years. There was no history of eye trauma or Valsalva-like maneuver effort. The best corrected visual acuity was 20/40 in both eyes and there was no relative afferent pupillary defect. Both eyes had normal IOP. A slit lamp examination revealed pool blood in the anterior chamber as hyphema grade 1. Fundus examination showed dot and blot hemorrhage with cupping discs 0.6 and 0.7. USG examination showed no mass and clear vitreous. The antiplatelet was stopped and evaluated by the internal department. The patient was observed and treated with topical medication, and the hyphema resolved within less than 7 days. Discussion : Although it is still not clear if there is any increase in intraocular bleeding has been recognized with antiplatelet agents, the concern would be greatest amongst those at high baseline risk due to predisposing conditions, such as elderly with diabetes, hypertension, and usage of antiplatelet agents to maintain cardiovascular disease. Conclusion : This case emphasizes that though the most common cause of hyphema is a traumatic injury, it can be a rare complication of antiplatelet therapy. Patients on antiplatelet therapy should be carefully monitored for ocular bleeding, especially if they have associated systemic or ocular comorbidity.
Co-Authors Ferdy Iskandar Klarissa Chrishalim Laura Agnestasia Djunaedi