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Arel, Afdhil
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Antioxidant Activity Test of Cinnamon Root Extract Cinnamomum burmanii (Nees & T.Nees) Blume) Based on Solvent Polarity Level Sri Wahyuni, Riza; Arel, Afdhil; Widya, Nurul
Indonesian Journal of Pharmaceutical Research Vol 4, No 2 (2024): Indo J Pharm Res 2024 4 (2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v4i2.6265

Abstract

Antioxidants are chemical compounds that can donate one or more electrons to free radicals to inhibit free radical reactions. One part of the plant that has the potential to act as an antioxidant is cinnamon root (Cinnamomum burmanii (Nees T.Nees) Blume). The aim of this research was to determine the antioxidant activity of cinnamon root based on solvent polarity. Antioxidant activity testing was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method and using vitamin C as a comparison solution. Antioxidant activity is expressed in the form of IC50. The results obtained from the maximum absorption wavelength of DPPH are 517 nm, with an absorbance of 0,717. The results of comparative antioxidant activity for vitamin C obtained IC50= 3,51 µg/mL, and samples of cinnamon root extract with IC50 values= 406 µg/mL for n-hexane extract, 53,2 µg/mL for ethyl acetate extract and 78,9 µg/mL for 70% ethanol extract. Based on the research results obtained, the antioxidant activity of the 70% ethanol and ethyl acetate cinnamon root extract samples is classified as strong (50- 100 µg/mL) while the n-hexane cinnamon root extract
FORMULATION OF Sweet Orange Fruit Peel (Citrus x sinensis (L.) Osbeck) ECO ENZIM GEL AND ACTIVITY TEST OF Propionibacterium acnes BACTERIES Gusrianti, Leli; Yenti, Revi; Arel, Afdhil
Indonesian Journal of Pharmaceutical Research Vol 4, No 2 (2024): Indo J Pharm Res 2024 4 (2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v4i2.6267

Abstract

This study aims to determine the anti-acne activity of a gel preparation from the eco enzyme of sweet orange peel against Propionibacterium acne. The method used in making eco enzymes is fermentation, while for testing antibacterial activity the paper disc diffusion method is used. Sweet orange peel eco enzyme gel formula with concentrations of (F0)0%, (F1)5%, and (F2)10% using carbopol 940. Anti-acne gel preparations were subjected to organoleptic test, pH, homogeneity, viscosity, irritation, stability and antibacterial activity tests against Propionibacterium acne. The research results showed that F0, F1 and F2 met the standard requirements with physical characteristics of a typical sweet orange scent for F1 and F2, as well as a carbopol scent for F0, a transparent white color for F0 and a pale yellow and yellow color for F1 and F2. It is thick and slightly viscous with a pH of 5, has a homogeneous shape, a viscosity of 3000-50000 cPs, is stable against cold and hot temperatures, and does not irritate the skin. The antibacterial activity test showed that all gel formulations could not inhibit the growth of Propionibacterium acne bacteria.
Formulasi dan Uji Aktifitas Facial Wash Ekstrak Buah Pare (Momordica charantia L) terhadap Bakteri Propionibacterium acnes Ningsih, Wida; Permata, Poppy lizia; Elvina, Ridha; Arel, Afdhil
Indonesian Journal of Pharmaceutical Research Vol 5, No 1 (2025): Indo J Pharm Res 2025 5 (1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v5i1.7031

Abstract

Abstrak: Produk perawatan kulit wajah yang digunakan sebagai pembersih adalah facial wash. Fungsinya mengatasi masalah kulit wajah, seperti mengangkat sel kulit mati, meremajakan kulit, menghilangkan kotoran, minyak dan melembabkan kulit. Facial wash merupakan kosmetik yang dapat membersihkan kulit wajah dari debu, polusi, dan minyak (sebum). Jerawat merupakan suatu bentuk gangguan pada kulit yang disebabkan oleh kulit yang tidak bersih dan adanya bakteri penyebab jerawat. Buah pare (Momordica charantia L) mengandung metabolit sekunder yang dapat menghambat bakteri penyebab jerawat. Penelitian ini bertujuan membuat facial wash yang mengandung antibakteri dari ektsrak buah pare. Facial wash dibuat dengan konsentrasi ekstrak buah pare 10 %, 12,5% dan 15% yang dilanjutkan pemerikasaan mutu dan penguajian aktifitas terhadap Propionibacterium acnes. Proses ekstraksi buah pare menggunkan metode maserasi dan pengujian antibakteri dengan metode difusi sumuran. Pemeriksaan mutu facial wash meliputi uji organoleptis, uji pH, uji tinggi busa, uji viskositas, uji homogenitas dan uji iritasi. Hasil pengujian menunjukkan semua formula facial wash stabil karena tidak terjadi perubahan selama penyimpanan. Pada pengujian aktivitas antibakteri ekstrak digunakan metode cakram dan didapat hasil diameter zona hambat yang berbeda pada setiap konsentrasi. Diameter zona hambat yang paling besar pada sediaan facial wash menggunakan metode sumuran ditunjukan pada F3 dengan konsentrasi ekstrak 15%  sebesar 9.55 mm.Kata Kunci: Facial wash, Antibakteri, Propionibacterium acnes
Rapid Detection and Quantification of Gambir Adulteration Using ATR-FTIR Spectroscopy Coupled with Chemometric Analysis Satria, Dedi; Eranisa, Yenni; Arel, Afdhil
Jurnal Riset Kimia Vol. 16 No. 2 (2025): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v16i2.858

Abstract

Gambir (an extract from Uncaria gambir Roxb.) is a valuable Indonesian herbal product susceptible to adulteration for economic gain. In this study, we developed a rapid, non-destructive method to detect and quantify adulteration in gambir using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy combined with chemometric analysis. In total, 32 gambir samples were prepared, including authentic gambir, samples adulterated with a fertilizer (SP36) at 0–50% w/w, quality control (pooled) samples, and a market sample of unknown purity. FTIR spectra (4000–600 cm−1) were collected. The spectral data were preprocessed and analyzed with PCA, SIMCA, and PLS-R. PCA revealed clear clustering of samples according to adulterant concentration, with the first two principal components capturing more than 99% of total variance. Chemometric classification models successfully distinguished authentic gambir from adulterated samples: SIMCA showed clear separation, with the 1% adulterant concentration sample clustering near authentic gambir, while the PLS-R calibration model achieved excellent linearity (R² ≈ 0.988) in predicting adulterant levels, with low RMSECV (≈ 0.0375) and a detection limit of ~0.54% adulterant concentration. When applied to a gambir sample obtained from the market, the PLS-R model indicated ~25% adulterant concentration. These results demonstrate that FTIR spectroscopy combined with multivariate analysis can effectively detect and quantify even low levels of adulterant concentration in gambir. This approach offers a fast and reliable tool for quality control and authentication of herbal products prone to adulteration.
Co-Authors Dedi Satria Elvina, Ridha Eranisa, Yenni Gusrianti, Leli Permata, Poppy lizia Sri Wahyuni, Riza Wida Ningsih Widya, Nurul