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All Journal e-CliniC JURNAL BIOMEDIK Medical Scope Journal (MSJ) Narra J
Kairupan, Tara S.
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan antara Mencuci Wajah dengan Kejadian Akne Vulgaris pada Remaja Laki-laki di Manado Sole, Fifin R. T.; Suling, Pieter L.; Kairupan, Tara S.
e-CliniC Vol 8, No 1 (2020): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v8i1.28310

Abstract

Abstract: Acne vulgaris is a chronic skin condition involving inflammation of the pilosebaceous follicle. The highest prevalence of acne vulgaris is at the age of 16-17 years. Pathogenic factors contributing to the development of acne vulgaris include increased sebum production, pilosebaceous follicular blockage, and increased colonization of Propionibacterium acnes. Personal hygiene is suggested as an important factor that needs to be maintained in acne prevention. Males tend to lack of awareness to seek information and health services in dealing with acne problems. This study was aimed to evaluate the relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado. This was an analytical and observational study using a cross-sectional design. Subjects were male students of 3rd grade at SMA Negeri 9 Manado, aged 16-19 years old, and met the inclusion and exclusion criteria, with a total number of 95 students. Subjects who washed their faces 2-3 times a day were 38 students (40%) while those who washed their faces less than twice or more than thrice a day were 57 students (60%). Subjects with no or mild acne vulgaris were 39 students (41.1%), while those with moderate to severe acne vulgaris were 56 students (58.9%). The chi-square showed a p-value of 0.004 for the relationship between the frequency of facial washing and the incidence of acne vulgaris. In conclusion, there was a significant relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado.Keywords: facial washing, acne vulgaris Abstrak: Akne vulgaris merupakan peradangan kronis folikel pilosebasea dengan prevalensi tertinggi pada usia 16-17 tahun. Faktor yang memengaruhi terjadinya akne vulgaris antara lain peningkatan produksi sebum, penyumbatan folikel pilosebasea, dan peningkatan kolonisasi bakteri Propionibacterium acnes. Kebersihan diri merupakan faktor penting yang perlu dijaga sebagai salah satu usaha untuk mencegah timbulnya akne. Laki-laki cenderung kurang memiliki kesadaran untuk mencari informasi dan pelayanan kesehatan dalam menangani masalah akne. Penelitian ini bertujuan untuk menilai hubungan antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Subjek penelitian ialah siswa laki-laki kelas 3 di SMA Negeri 9 Manado, usia 16-19 tahun, dan memenuhi kriteria inklusi dan eksklusi, dengan jumlah total 95 siswa. Subjek yang mencuci wajah 2-3 kali sehari sebanyak 38 siswa (40%) sedangkan yang mencuci wajah kurang dari 2 kali atau lebih dari 3 kali sehari sebanyak 57 siswa (60%). Subjek tanpa akne vulgaris atau akne derajat ringan sebanyak 39 siswa (41,1%) sedangkan yang dengan akne vulgaris derajat sedang sampai berat sebanyak 56 siswa (58,9%). Uji chi-square memperlihatkan nilai p=0.004 terhadap hubungan antara frekuensi mencuci wajah dengan kejadian akne vulgaris. Simpulan penelitian ini ialah terdapat hubungan bermakna antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado.Kata kunci: mencuci wajah, akne vulgaris
Pengaruh Menstruasi terhadap Akne Vulgaris Hartono, Lusiane M.; Kapantow, Marlyn G.; Kairupan, Tara S.
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.9.2.2021.32734

Abstract

Abstract: Acne vulgaris is a common inflammatory condition of pilosebaceous follicles that affects 85-100% of the human population. Patients usually complain of the appearance of acne vulagaris on the predilection areas such as face and neck (99%), back (60%), chest, shoulders and upper arms (15%). One of the factors that influence or trigger acne vulgaris is hormonal factor. During menstruation there is an increase and hormonal changes that can trigger acne. This study was aimed to determine the effect of menstruation on acne vulgaris. This was a literature review study using three databases named PubMed, ClinicalKey and Google Scholar. Keywords used were “Menstruasi” DAN “Akne Vulgaris” (Indonesia), and “Menstruation” AND “Acne Vulgaris” (English). In this study, there were 12 literatures that match the inclusion and exclusion criteria. The result was dominated by samples stating that there was a connection between menstruation and the appearance of acne vulgaris. The effect of hormonal instability during menstruation was one of the causes of acne vulgaris in women, which showed the effect of menstruation on the emergence of acne vulgaris, mostly during pre-menstruation. In conclusion, menstruation influences the occurrence and the severity of acne vulgaris.Keywords: menstruation, acne vulgaris  Abstrak: Akne vulgaris (AV) atau jerawat merupakan suatu kondisi inflamasi umum pada folikel pilosebasea yang dialami oleh 85-100% populasi manusia. Penderita biasanya mengeluh kemunculan AV pada predileksi wajah dan leher (99%), punggung (60%), dada (15%) bahu, dan lengan bagian atas. Faktor yang memengaruhi atau mencetuskan akne vulgaris salah satunya ialah faktor hormonal. Saat menstruasi terjadi peningkatan dan perubahan hormon yang dapat memicu akne. Penelitian ini bertujuan untuk mengetahui pengaruh menstruasi terhadap akne vulgaris. Penelitian ini berbentuk literature review. Pencarian data menggunakan tiga database yaitu PubMed, ClinicalKey dan Google Scholar. Kata kunci yang digunakan “Menstruasi” DAN “Akne Vulgaris” (Bahasa Indonesia) serta “Menstuation” AND “Acne Vulgaris” (Bahasa Inggris). Pada penelitian ini didapatkan 12 literatur yang sesuai dengan kriteria inklusi dan ekslusi. Hasil penelitian didominasi oleh sampel yang menyatakan adanya pengaruh antara menstruasi dengan munculnya AV. Pengaruh ketidakstabilan hormon (estrogen dan progesteron) saat menstruasi merupakan salah satu penyebab munculnya akne vulgaris pada perempuan yang menunjukan adanya pengaruh dari menstruasi terhadap kemunculan AV, terlebih pada saat pre-menstruasi. Simpulan penelitian ini ialah menstruasi memengaruhi kemunculan dan keparahan akne vulgaris.Kata kunci: menstruasi, akne vulgaris
Efektivitas Anti Jamur Sistemik Terhadap Dermatofitosis Warouw, Mathilda W.; Kairupan, Tara S.; Suling, Pieter L.
JURNAL BIOMEDIK : JBM Vol 13, No 2 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.2.2021.31833

Abstract

Abstract: Dermatophytosis or tinea is the most frequent fungal infection in the world caused by the dermatophyte fungi group. These dermatophytes infect the stratum corneum of the skin, hair shaft, and nails. Systemic antifungals are one of the treatment options for dermatophytosis, especially in cases of widespread infection or failure of topical therapy. This study aims to determine the effectiveness of various systemic antifungals (griseofulvin, terbinafine, and azole derivatives) against dermatophytosis. This study was in the form of a literature review by searching and collecting data using the PubMed and ClinicalKey databases, with the keywords antifungal sistemik, dermatofitosis, tinea (bahasa Indonesia), and systemic antifungal, dermatophytosis, tinea (English). Based on the results of the literature search, 10 articles were found that match the inclusion and exclusion criteria. From the article review, it is known that the effectiveness of systemic antifungal therapy against dermatophytosis varies according to the classification and duration of therapy. In conclusion, systemic antifungals in the treatment of dermatophytosis have been shown to be effective.Keywords: systemic antifungal, dermatophytosis, tinea  Abstrak: Dermatofitosis atau kata lainnya tinea merupakan infeksi jamur paling sering di dunia yang disebabkan oleh golongan jamur dermatofita. Dermatofita  ini menginfeksi stratum korneum kulit, batang rambut, dan kuku. Antijamur sistemik merupakan salah satu pilihan terapi dermatofitosis terutama pada kasus infeksi luas atau kegagalan terapi topikal. Penelitian ini bertujuan untuk mengetahui efektivitas dari berbagai antijamur sistemik (griseofulvin, terbinafin, dan turunan azole) terhadap dermatofitosis. Penelitian ini berbentuk literature review dengan pencarian dan pengumpulan data menggunakan database PubMed dan ClinicalKey, dengan kata kunci antijamur sistemik, dermatofitosis, tinea (Bahasa Indonesia), serta systemic antifungal, dermatophytosis, tinea (Bahasa Inggris). Berdasarkan hasil pencarian literatur didapatkan 10 artikel yang sesuai dengan kriteria inklusi dan eksklusi. Dari tinjauan artikel diketahui efektivitas dari pemberian terapi antijamur sistemik terhadap dermatofitosis bervariasi sesuai klasifikasi dan durasi terapi. Sebagai simpulan, antijamur sistemik pada terapi dermatofitosis terbukti efektif.Kata kunci: antijamur sistemik, dermatofitosis, tinea.
Gambaran Pengetahuan, Sikap, dan Tindakan Penggunaan Tabir Surya pada Mahasiswa Program Studi Kedokteran Umum Fakultas Kedokteran Universitas Sam Ratulangi Siregar, Angel R. F.; Kairupan, Tara S.; Mawu, Ferra O.
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.53652

Abstract

Abstract: Excessive exposure of skin to sunlight without protection can lead to skin damage such as sunburn, pigmentation disorders, premature aging, and increased risk of skin cancer. Sunscreen application is an effective method to protect the skin from adverse effects of sunlight. The proper selection and correct application of sunscreen significantly influence its effectiveness in protecting the skin. This study aimed to assess the knowledge, attitude, and action related to sunscreen usage among medical students of Universitas Sam Ratulangi. This was a descriptive study with a cross-sectional design. Primary data were collected by distributing questionnaires to the medical students. The results showed that the knowledge level of the respondents was categorized as fair (44.2%); the attitude towards sunscreen usage was considered good (57.4%); and the action of sunscreen application was poor (48.6%). In conclusion, related to sunscreen usage, medical students of Universitas Sam Ratulangi have fair knowledge and action meanwhile the attitude is in the good category. Keywords: sunscreen; ultraviolet radiation; medical students   Abstrak: Paparan sinar matahari berlebihan pada kulit tanpa perlindungan dapat menimbulkan kerusakan kulit seperti sunburn, gangguan pigmentasi, penuaan dini, serta meningkatkan risiko kanker kulit. Tabir surya merupakan salah satu cara yang dapat dilakukan untuk melindungi diri dari dampak negatif sinar matahari. Cara pemilihan tabir surya yang ideal dan penggunaan tabir surya yang baik dan benar sangat memengaruhi efektivitas tabir surya dalam melindungi kulit. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan, sikap, dan tindakan penggunaan tabir surya pada mahasiswa Program Studi Kedokteran Umum Fakultas Kedokteran Universitas Sam Ratulangi (FK Unsrat). Jenis penelitian ialah deskriptif dengan desain potong lintang. Data primer dikumpulkan dengan membagikan kuesioner kepada mahasiswa FK Unsrat. Hasil penelitian mendapatkan tingkat pengetahuan responden berada di kategori cukup (44,2%), tingkat sikap penggunaan tabir surya responden berada di kategori baik (57,4%) dan tingkat tindakan penggunaan tabir surya responden berada di kategori cukup (48,6%). Simpulan penelitian ini ialah pengetahuan serta tindakan responden berada pada kategori cukup, sedangkan sikap responden pada kategori baik. Kata kunci: tabir surya; sinar ultraviolet; mahasiswa kedokteran
Psoriasis severity assessment: Optimizing diagnostic models with deep learning Maulana, Aga; Noviandy, Teuku R.; Suhendra, Rivansyah; Earlia, Nanda; Prakoeswa, Cita RS.; Kairupan, Tara S.; Idroes, Ghifari M.; Subianto, Muhammad; Idroes, Rinaldi
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1512

Abstract

Psoriasis is a chronic skin condition with challenges in the accurate assessment of its severity due to subtle differences between severity levels. The aim of this study was to evaluate deep learning models for automated classification of psoriasis severity. A dataset containing 1,546 clinical images was subjected to pre-processing techniques, including cropping and applying noise reduction through median filtering. The dataset was categorized into four severity classes: none, mild, moderate, and severe, based on the Psoriasis Area and Severity Index (PASI). It was split into 1,082 images for training (70%) and 463 images for validation and testing (30%). Five modified deep convolutional neural networks (DCNN) were evaluated, including ResNet50, VGGNet19, MobileNetV3, MnasNet, and EfficientNetB0. The data were validated based on accuracy, precision, sensitivity, specificity, and F1-score, which were weighted to reflect class representation; Pairwise McNemar's test, Cochran's Q test, Cohen’s Kappa, and Post-hoc test were performed on the model performance, where overall accuracy and balanced accuracy were determined. Findings revealed that among the five deep learning models, ResNet50 emerged as the optimum model with an accuracy of 92.50% (95%CI: 91.2–93.8%). The precision, sensitivity, specificity, and F1-score of this model were found to be 93.10%, 92.50%, 97.37%, and 92.68%, respectively. In conclusion, ResNet50 has the potential to provide consistent and objective assessments of psoriasis severity, which could aid dermatologists in timely diagnoses and treatment planning. Further clinical validation and model refinement remain required.
Karakteristik Bercak Kulit yang Dicurigai Pitiriasis Versikolor pada Warga Binaan di Lembaga Pemasyarakatan Kelas IIA Tuminting Manado Ngantung, Hana N. E. N.; Kapantow, Marlyn G.; Kairupan, Tara S.
e-CliniC Vol. 12 No. 3 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i3.55439

Abstract

Abstract: Pityriasis versicolor is a disease caused by the Malassezia fungus with general symptoms in the form of hypopigmented, hyperpigmented, or erythematous spots. Pityriasis versicolor is often found, especially in tropical areas. This study aimed to determine the characteristics of skin spots suspected of pityriasis versicolor in inmates at the Class IIA Tuminting Manado Correctional Institution. This was a descriptive study with a cross-sectional design using quantitative methods. The results obtained 30 male inmates who had skin spots and were suspected of pityriasis versicolor. Skin lesions were most common in those aged 25-44 years (37%), level of education, namely high school (40%), the residential capacity of the inmates did not meet the requirements of 5.4 m2/person, hypopigmented lesions (90%), without complaints of pruritus (63%). The location of the lesions occurred in the body area (57%), combined areas (23%), and extremities (10%). Based on Wood's lamp and microscope examination, the overall examination results were negative (100%). In conclusion, skin spots suspected of pityriasis versicolor in inmates were negatively tested, therefore, it was confirmed as not pityriasis versicolor. Keywords: pityriasis versicolor; skin spots; penitentiary; Wood's lamp    Abstrak: Pitiriasis versikolor adalah penyakit yang timbul disebabkan oleh jamur Malassezia dengan gejala umum berupa bercak hipopigmentasi, hiperpigmentasi atau eritamatosa. Pitiriasis versikolor sering ditemukan terutama di daerah tropis. Penelitian ini bertujuan untuk mengetahui karakteristik bercak kulit yang dicurigai pitiriasis versikolor pada warga binaan di Lembaga Pemasyarakatan Kelas IIA Tuminting Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang menggunakan metode kuantitatif. Hasil penelitian mendapatkan 30 orang warga binaan laki-laki yang mempunyai bercak kulit dicurigai pitiriasis versikolor. Bercak kulit terbanyak ditemukan pada warga binaan usia 25-44 tahun  (37%), memiliki tingkat pendidikan SMA (40%), kapasitas hunian warga binaan tidak memenuhi syarat 5,4 m2/orang, warna lesi hipopigmentasi (90%), tidak ada keluhan pruritus (63%). Lokasi lesi terjadi pada area badan (57%), area kombinasi (23%), dan ekstremitas (10%). Berdasarkan pemeriksaan lampu Wood dan mikroskop, hasil pemeriksaan keseluruhan negatif (100%). Simpulan penelitian ini ialah bercak kulit dicurigai pitiriasis versikolor pada warga binaan dengan hasil pemeriksaan negatif sehingga dinyatakan bukan pitiriasis versikolor.  Kata kunci: pitiriasis versikolor; bercak kulit; lembaga pemasyarakatan; lampu Wood
Mechanistic insights into the anticancer, anti-inflammatory, and antioxidant effects of yellowfin tuna collagen peptides using network pharmacology Kairupan, Tara S.; Kapantow, Nova H.; Tallei, Trina E.; Niode, Nurdjannah J.; Sanggelorang, Yulianty; Rotty, Linda WA.; Wungouw, Herlina IS.; Kawengian, Shirley ES.; Fatimawali, Fatimawali; Maulydia, Nur B.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1885

Abstract

Marine-derived collagen peptides have been acknowledged for their therapeutic potential, especially in cancer therapy and inflammation management. The aim of this study was to investigate the molecular mechanisms that contribute to the anticancer, anti-inflammatory and antioxidant properties of yellowfin tuna collagen peptides (YFTCP) utilizing a network pharmacology approach. The YFTCP was extracted from the bones of yellowfin tuna (Thunnus albacares) and subsequently hydrolyzed with trypsin. Seventeen peptides were discovered using liquid chromatography in conjunction with high-resolution mass spectrometry (LC-HRMS). A network pharmacology method was utilized to investigate the interactions between the discovered peptides and their biological targets. Additionally, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify pertinent biological pathways involved in the anticancer, antioxidant, and anti-inflammatory effects of these peptides. GO analysis revealed key associations between YFTCP and critical cancer- and inflammation-related genes encoding proteins such as CCND1, SRC, AKT1, IL-1β, TNF, and PPARG, which exhibited significant interactions. These proteins are essential for the regulation of the cell cycle, the development of tumors, and the response to inflammatory stimuli. The KEGG analysis also revealed that YFTCP was involved in a number of critical pathways, such as endocrine resistance, cancer pathways, Kaposi sarcoma-associated herpesvirus infection, proteoglycans in cancer, and human cytomegalovirus infection. These findings highlight the potential use of YFTCP as a multifaceted therapeutic agent, indicating their role in regulating important biological pathways associated with cancer development and inflammation. This study provides new valuable insights into the pharmacological properties of YFTCP, paving the way for future studies and drug development focused on these bioactive peptides.
Co-Authors Earlia, Nanda Fatimawali . Ferra O. Mawu, Ferra O. Hartono, Lusiane M. Idroes, Ghifari M. Kawengian, Shirley ES. Marlyn G. Kapantow Maulana, Aga Maulydia, Nur B. Muhammad Subianto Ngantung, Hana N. E. N. Nova Hellen Kapantow Noviandy, Teuku R. Nurdjannah J. Niode Pieter L. Suling Prakoeswa, Cita RS. Rinaldi Idroes Rotty, Linda WA. Siregar, Angel R. F. Sole, Fifin R. T. Suhendra, Rivansyah Trina E. Tallei, Trina E. Warouw, Mathilda W. Wungouw, Herlina IS. Yulianty Sanggelorang