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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Heca Journal of Applied Sciences Malacca Pharmaceutics Indonesian Journal of Case Reports Journal of Innovative and Creativity
Earlia, Nanda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Chronic cutaneous chromoblastomycosis: A rare case Earlia, Nanda; Maulida, Mimi; Handriani, Risna; Kamarlis, Reno Keumalazia; Pradistha, Aldilla
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Chromoblastomycosis (CBM) is a rare, chronic granulomatous and suppurative skin infection classified as a subcutaneous mycosis. CBM has a poor prognosis with a low cure rate and a high recurrence rate. The lack of scientific data regarding the diagnosis and treatment of CBM also presents a challenge for clinicians in treating this disease. Appropriate therapy can increase the cure rate and prevent disease recurrence. Case Illustration: A 66-year-old woman presented with swelling in her left arm since the last 18 years due to wood-related injuries. There were multiple well-defined hyperkeratotic verrucous plaques, papules, and nodules, measuring 6-10 cm in diameter on the left antebrachial and hand regions. Some lesions were covered with erosion and crusts. The patient also had bone malformation. Histopathological examination showed typical characteristics of CBM. The patient was treated with 100 mg Itraconazole b.i.d. for 8 months. Discussion: Clinical manifestations and histopathological examination showed typical characteristics of CBM. Bone malformation occurred due to complications in chronic cases. Facility limitations led to the inability to perform direct microscopic examination using potassium hydroxide (KOH) and fungal culture on Sabouraud's dextrose agar. After 8 weeks of treatment, the patient's lesions were improved. The patient will be evaluated every month until treatment is complete to monitor the side effects of therapy. Conclusion: CBM lesions were improved after 8 weeks of treatment. Bone malformation could occur in chronic cases. It is important to diagnose CBM correctly and provide adequate therapy for a good outcome.
The Profiles of Infantile Hemangiomas Patients hidayati, Arie; earlia, Nanda; Sari, Ninda; Vella; Maulida, Mimi; asrizal, Cynthia wahyu
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.130-135

Abstract

Background: Infantile hemangiomas (IH) are the most prevalent benign tumors in children, predominantly in girls. Most IH cases do not require treatment due to spontaneous involution, but 10% of cases do require early treatment due to size, location, and complications. Purpose: This study tried to define the profile, clinical aspects, and therapy of IH in Dr. Zainoel Abidin General Hospital, Banda Aceh. Methods: A descriptive approach using a retrospective analysis employing secondary data from the outpatient clinic's patient registration book. This study included all new cases of infantile hemangioma at the outpatient clinic general hospital between 2013 and 2021. Result: A total of 105 patients were involved in this study. The majority of IH patients (59%) were under the age of one year, with 64 female patients (61%) making the most visits to the pediatric clinic in 2017, 2018, and 2019 (77.1%). The most prevalent clinical features of skin lesions were nodules in 69 individuals (65.7%), and the most common site was the facial region (13.3%) in 44 patients. In 20 individuals, a combination of propanolol and oral corticosteroids was used as the most effective treatment strategy (19% ). Conclusion: Infantile hemangiomas is the most frequently reported benign tumor in children. Females are more likely than males to develop IH. The majority of IH is minor and normally resolves on its own without therapy. However, certain rare kinds of IH require clinician attention and systematic treatment.
Generalized Pustular Psoriasis in Childhood: A Rare Case Asnawi, Vella; Maulida, Mimi; Earlia, Nanda; Hidayati, Arie; Ismida, Fitri Dewi; Liana, Mahda Rizki; Maghfirah, Karamina; Bulqiah, Mikyal
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.231-236

Abstract

Background: Generalized pustular psoriasis (GPP) rarely occurs under 10 years of age. GPP is typically characterized by an eruption of generalized pustules accompanied by systemic symptoms such as fever for several days, malaise, and anorexia. Pustules are sterile, with a size of 2-3 mm, and spread over the trunk and extremities. This disease can be life-threatening; therefore, optimal therapy is required. Purpose: to report a rare case of GPP in childhood. Case: A 4-year-old girl with complaints of widespread red patches that spread to her neck, back, and hands, with red patches turning into streaks that are partially pus-filled and itchy. In almost all parts of the body, skin abnormalities were seen in the form of generalized erythematous plaques, well-defined borders, multiple pustules on the edges, and some plaques covered by thick scales and crusts. In the calculation of body surface area (BSA), the result is 44%, and in the calculation of generalized pustular psoriasis area and severity index (GPPASI), the result is 21.30. The patient was treated with combination topical therapy of 3% salicylic acid, desoximethasone cream 0.25%, momethasone cream 0.1% vaseline albume as emollients, and coal tar. Significant improvement was seen after 1 month of therapy. Discussion: GPP in children is a rare case. GPP is idiopathic and can be life-threatening. Until now, there has been no standard therapy that is considered the most effective and safe for children. Topical therapy may be an option.
Evaluation of Gradient Boosted Classifier in Atopic Dermatitis Severity Score Classification Suhendra, Rivansyah; Suryadi, Suryadi; Husdayanti, Noviana; Maulana, Aga; Noviandy, Teuku Rizky; Sasmita, Novi Reandy; Subianto, Muhammad; Earlia, Nanda; Niode, Nurdjannah Jane; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.85

Abstract

This study investigates the application of the Gradient Boosting machine learning technique to enhance the classification of Atopic Dermatitis (AD) skin disease images, reducing the potential for manual classification errors. AD, also known as eczema, is a common and chronic inflammatory skin condition characterized by pruritus (itching), erythema (redness), and often lichenification (thickening of the skin). AD affects individuals of all ages and significantly impacts their quality of life. Accurate and efficient diagnostic tools are crucial for the timely management of AD. To address this need, our research encompasses a multi-step approach involving data preprocessing, feature extraction using various color spaces and evaluating classification outcomes through Gradient Boosting. The results demonstrate an accuracy of 93.14%. This study contributes to the field of dermatology by providing a robust and reliable tool to support dermatologists in identifying AD skin disease, facilitating timely intervention and improved patient care.
Pengaruh Fototerapi Terhadap Mikrobioma Kulit dan Keparahan Penyakit Pada Pasien Dermatitis Atopik: Effect of Phototherapy on Skin Microbiome and Disease Severity in Atopic Dermatitis Patients Earlia, Nanda; Elfa Wirdani Fitri; Bulqiah, Mikyal; Tasrif, Aqil Yuniawan
Journal of Medical Science Vol 5 No 1 (2024): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v5i1.139

Abstract

Dermatitis atopik (DA) merupakan salah satu penyakit inflamasi kronis bersifat gatal dan residif. Pasien DA cenderung mengalamiinfeksi kulit yang dapat memperparah dan mencetus kekambuhan. Modalitas tatalaksana DA sedang dan berat terkini adalah penggunaan fototerapi. Fototerapi dengan menggunakan Narrowband-UVB (NB-UVB) dapat dipertimbangkan sebagai terapi lini kedua pasien DA sedang dan berat setelah gagal terapi lini pertama. Selain efek antiinflamasi, fototerapi NB-UVB memiliki efek antibiotik sehingga bermanfaat dalam mengatasi infeksi kulit pada pasien DA. Tujuan penelitian ini adalah untuk mengetahuiefektivitas pemberian fototerapi terhadap mikrobioma kulit dan keparahan penyakit DA. Penelitian ini merupakan penelitian uji klinis(clinical trials) desain paralel dengan matching. Populasi penelitian ini adalah seluruh penderita DA yang berobat di poliklinik kulit dankelamin RSUDZA yang memenuhi kriteria inklusi dan ekslusi. Sebanyak 20 pasien terlibat dalam penelitian ini, yang terbagi menjadi 2 kelompok yaitu kelompok perlakuan yaitu pasien yang diterapi dengan fototerapi sebanyak 2 kali per minggu, selama 4 minggu dan kelompok kontrol tanpa fototerapi. Pemeriksaan keparahan penyakit dengan parameter SCORAD, EASI, ADSI, TEWL dan Scap sertaswab kulit untuk deteksi mikrobioma dilakukan sebelum dan sesudah intervensi. Hasil analisa menggunakan uji t tidak berpasanganmenunjukkan pemberian fototerapi selama 8 kali secara signifikan mengurangi keparahan penyakit dengan parameter SCORAD, EASI, ADSI, TEWL dan Scap (nilai p<0.05) dibandingkan dengan kelompok kontrol. Namun, tidak halnya dengan mikrobioma kulit(p>0.05).
A fatal case of Harlequin ichthyosis: Experience from low-resource setting Vella, Vella; Maulida, Mimi; Earlia, Nanda; Hidayati, Arie; Handriani, Risna; Gondokaryono, Srie P.; Dwiyana, Reiva F.; Doris , Ezigbo E.; Pradistha , Aldilla; Bulqiah, Mikyal
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.302

Abstract

Harlequin ichthyosis is a severe and fatal presentation of ichthyosis with an autosomal recessive inheritance. Infants with Harlequin ichthyosis have a high mortality rate, and a dismal prognosis; therefore the majority of neonates die shortly after birth from infection, heat loss, dehydration, electrolytic imbalances, or respiratory distress. The aim of this case report was to present a fatal case of Harlequin ichthyosis with no family history of any inherited skin disorder. A 3-day-old baby was presented to the emergency room with congenital abnormalities at birth, fissured hyperkeratotic skin, and thick yellow plates of scales. The parents had no history of consanguineous marriage, no relevant past medical history, and no family history of the same condition. The patient was unwell, pulse 162 times/minute, respiratory rate 48 times/minute, and axillary temperature 36.9oC. APGAR score was 8 in the 1st minute and 9 in the 5th minute. Based on the typical clinical appearance, the patient was diagnosed with Harlequin ichthyosis. Due to a lack of facility, a mutation analysis was not carried out. The patient was then transferred to the neonatal intensive care unit (NICU) and treated in a humidified incubator and medicated with intravenous antibiotics (ampicillin sulbactam 125 mg/12 hour and gentamicin 13 mg/24 hour), topically fusidic acid and mild emollients. A central venous catheter was used for intravenous access. The poor prognosis resulted in the patient dying at the age of 5-day-old. This case highlights that prenatal diagnosis is critical for early detection and disease prevention. Mutation screening for the ABCA12 gene is suggested for consanguinity marriages and with a history of ichthyosis.
Evaluation of atopic dermatitis severity using artificial intelligence Maulana, Aga; Noviandy, Teuku R.; Suhendra, Rivansyah; Earlia, Nanda; Bulqiah, Mikyal; Idroes, Ghazi M.; Niode, Nurdjannah J.; Sofyan, Hizir; Subianto, Muhammad; Idroes, Rinaldi
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.511

Abstract

Atopic dermatitis is a prevalent and persistent chronic inflammatory skin disorder that poses significant challenges when it comes to accurately assessing its severity. The aim of this study was to evaluate deep learning models for automated atopic dermatitis severity scoring using a dataset of Aceh ethnicity individuals in Indonesia. The dataset of clinical images was collected from 250 patients at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia and labeled by dermatologists as mild, moderate, severe, or none. Five pre-trained convolutional neural networks (CNN) architectures were evaluated: ResNet50, VGGNet19, MobileNetV3, MnasNet, and EfficientNetB0. The evaluation metrics, including accuracy, precision, sensitivity, specificity, and F1-score, were employed to assess the models. Among the models, ResNet50 emerged as the most proficient, demonstrating an accuracy of 89.8%, precision of 90.00%, sensitivity of 89.80%, specificity of 96.60%, and an F1-score of 89.85%. These results highlight the potential of incorporating advanced, data-driven models into the field of dermatology. These models can serve as invaluable tools to assist dermatologists in making early and precise assessments of atopic dermatitis severity and therefore improve patient care and outcomes.
An Intriguing Case of Erythroderma Possibly Related to Psoriasis Vulgaris Earlia, Nanda; Umborowati, Menul Ayu; Tasrif, Aqil Yuniawan; Pradistha, Aldilla; Liana, Mahda Rizki; Bulqiah, Mikyal
Indonesian Journal of Case Reports Vol. 1 No. 1 (2023): August 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v1i1.56

Abstract

Erythroderma or generalized exfoliating dermatitis is an inflammatory disease characterized by erythema and thickened scales. A woman, 34 years old, was consulted with complaints of red spots accompanied by blisters and peeling skin almost all over her body for 4 days. Complaints are accompanied by itching and burning sensations. The patient had experienced complaints like this 5 months ago and had been treated at three different hospitals. Physical examination found in the facial region, thorax, superior and inferior right and left extremities, erythematous patches with diffuse borders, thick scales, erosions, and a generalized distribution. The patient's fingernails were found to have a change in shape (pitting nails). Examination of the ANA profile was negative, IgE atopy did not show an allergic reaction to a specific allergen, and histopathological examination was within normal limits. The patient was diagnosed with erythroderma based on psoriasis vulgaris. Treatment includes injection of methylprednisolone, cetirizine 10 mg tablets, and wound care with wet gauze and topical cream. After giving therapy, the patient's clinical improvement. Erythroderma occurs because of an underlying condition and cannot be prevented by itself. Erythroderma because of an underlying inflammatory skin condition usually resolves with treatment but can recur at any time. Overall, the prognosis for erythroderma depends on the underlying cause and is generally good if the underlying disease can be treated effectively.
Comprehensive Treatment Approaches in a Unique Case of Generalized Pustular Psoriasis Earlia, Nanda; Maulida, Mimi; Badiri, Istanul; Pradistha, Aldilla; Bulqiah, Mikyal; Fajrina, Nur
Indonesian Journal of Case Reports Vol. 1 No. 2 (2023): December 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v1i2.113

Abstract

Psoriasis is an immunological inflammatory disease characterized by skin inflammation and epidermal hyperplasia. One type of psoriasis is Generalized Pustular Psoriasis (GPP), which is usually preceded by other diseases. A 56-year-old woman presented to the Department of Dermatology and Venereology with a recent onset of red spots accompanied by pustules distributed across her body. The initial manifestation of these symptoms occurred approximately one month prior, and the condition has progressively worsened over the past three days. Physical examination of dermatological status showed erythematous plaques with smooth, well-defined scales with irregular, round edges, lenticular size, multiple, discrete, and confluent distribution, generalized distribution in the pedis dextra et sinistra, manus dextra et sinistra, and femoral regions. Skin biopsy examination results showed skin tissue with hyperkeratosis, acanthosis, and parakeratosis, with PMN inflammatory cells (Munro's micro abscess). The conclusion of the skin biopsy is pustular psoriasis. The patient was diagnosed with GPP. Patients were given Methotrexate, calcitriol tablets 0.25 mcg twice a day, cetirizine tablets 10 mg twice a day, and topical cream. After one week of treatment, the patient's lesions improved. Treatment continues, and patients are given education to avoid trigger factors such as stress, excessive activity, extreme temperature changes, and focal infections. The management must consider various influencing factors, including genetic factors, skin barriers, predisposing factors, and trigger factors. Prevention is also important. The patient needs to be educated about the details of the disease, how to prevent a recurrence, and treatment when the disease recurs.
Clinical Insights and Diagnostic Dilemmas: Two Cases of Livedoid Vasculitis Earlia, Nanda; Budini, Sulamsih Sri; Lestari, Wahyu; Handriani, Risna; Ismida, Fitri Dewi; Pradistha, Aldilla; Dinillah, Teuku Muhammad Muizzy; Vemulen, Dara Avinda; Athira, Athira
Indonesian Journal of Case Reports Vol. 2 No. 1 (2024): June 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i1.183

Abstract

Livedoid Vasculitis (LV) is a thrombo-occlusive vasculopathy involving dermal vessels, especially in the lower extremities. Clinical symptoms of LV are chronic, recurrent, scarring, and painful purpuric ulcers. Diagnosing and providing therapy for LV is a challenge because there are no standard guidelines. We present clinical insights and diagnostic approaches on two cases of LV to improve early diagnosis and prevent misdiagnosis, which were confirmed based on history, dermatological examination, and skin biopsy. In the first case, it was a woman, 23 years old, who came with complaints of a blackish-red rash appearing on both legs. There were scars on several parts of the patient's legs, which felt painful, and the legs looked swollen. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. In the second case, it was a man, 19 years old, who came with complaints of pain when walking accompanied by wounds on both lower legs. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. The conclusion from the histopathology results was LV. After receiving therapy, both cases showed improvement: swelling in the legs was reduced, red and black rashes began to disappear, ulcers improved, pain decreased, and scars became blurred. These two cases provide examples of success in diagnosing LV. Being able to diagnose LV early and correctly is very important so that adequate therapy can be given and good outcomes can be achieved.
Co-Authors . Zulfan Abdurrazaq Abdurrazaq, Abdurrazaq Agustyananda, Dedi Alghani, Fajri Amelia Sari Asnawi, Vella asrizal, cynthia wahyu Athira, Athira Azzahra, Shelda Syifa Badiri, Istanul Bulqiah, Mikyala Dinillah, Teuku Muhammad Muizzy Doris , Ezigbo E. Dwiyana, Reiva F. Elfa Wirdani Fitri Endang Lukitaningsih Farsa, Bianda Sabrina Fitria Fitria Gondokaryono, Srie P. Handriani, Risna Hanum, Faridah Hayati, Rima hidayati, Arie Hizir Sofyan Husdayanti, Noviana Ibrahim, Teuku Maulana Malik Idroes, Ghazi M. Idroes, Ghifari M. Ikram, Tubagus Pasca Faiz Ismida, Fitri Dewi Kairupan, Tara S. Liana, Mahda Rizki Maghfirah, Karamina Maulana, Aga Maulida, Mimi Maulidina, Rizka Yuliani Menul Ayu Umborowati, Menul Ayu Mikyal Bulqiah, Mikyal Muhammad Subianto Murtadha, Raihan Nabilah, Nada Niode, Nurdjannah Jane Noviandy, Teuku R. NUR FAJRINA Nurdjannah J. Niode Pradistha , Aldilla Pradistha, Aldilla Prakoeswa, Cita RS. Rahmatillah, Muhammad Zahrul Ramadhani, Cut Sukma Razaq, Abdur Reno Keumalazia Kamarlis Rinaldi Idroes Salim, Fitria Sari, Ninda Sasmita, Novi Reandy SITTI HAJAR Suhendra, Rivansyah Sulamsih Sri Budini, Sulamsih Sri Suryadi Suryadi Tasrif, Aqil Yuniawan Teuku Rizky Noviandy Vella Vella, Vella Vemulen, Dara Avinda Wahyu Lestari Wisesa, Wizurai Yoo, Soo-Ji Zakaria, Sri Rezeki Zuhra, Sofi Alfia