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Perbedaan Kadar Natrium pada Packed Red Cell Berdasarkan Lama Penyimpanan di Bank Darah RSUP Dr. M. Djamil Padang Hesty Rhauda Ashan
Jurnal Kesehatan Andalas Vol 9, No 1 (2020): Online March 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i1.1237

Packed Red Cell (PRC) adalah komponen darah yang didapat setelah sebagian besar plasma dipisahkan dari Whole Blood (WB) dan memiliki nilai hematokrit sekitar 80%. Packed red cell disimpan pada suhu 2-6°C selama 21–42 hari tergantung larutan antikoagulan-pengawet yang digunakan. Pompa Na+/K+ATPase menjadi inaktif pada suhu 4°C menyebabkan natrium masuk ke dalam sel dan kalium keluar dari sel. Proses ini terjadi perlahan dan terus menerus sehingga kadar natrium pada plasma PRC menurun sesuai dengan bertambahnya waktu penyimpanan. Tujuan: Menentukan perbedaan kadar natrium PRC antara penyimpanan ≤14 hari dan >14 hari di bank darah RSUP Dr.M.Djamil Padang. Metode: Penelitian ini adalah suatu penelitian analitik dengan rancangan potong lintang, dimulai dari bulan September 2016 sampai Oktober 2018. Kadar natrium diperiksa dengan electrolyte analyzer. Analisis data menggunakan uji-t, bermakna bila p<0,05. Hasil: Rerata kadar natrium pada penyimpanan ≤14 hari adalah 150,5 (2,9) mmoL/L dan 143,3 (4,3) mmoL/L pada penyimpanan >14 hari. Terdapat perbedaan bermakna rerata kadar natrium PRC berdasarkan lama penyimpanan (p= 0,0001). Simpulan: Terdapat perbedaan kadar natrium PRC pada lama penyimpanan ≤14 hari dan >14 hari.Kata kunci: lama penyimpanan, jejas penyimpanan, natrium, packed red cell

ASPERGILLUS SP. PADA ULKUS KORNEA Hesty Rhauda Ashan; Ellyza Nasrul; Abdul Aziz Djamal
HUMAN CARE JOURNAL Vol 5, No 2 (2020): Human Care Journal Special Edition
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i2.737

Aspergillosis is a disease caused by Aspergillus sp., especially Aspergillus fumigatus which induce granulomatosis inflammation in mucous membranes, eyes, bronchi, ears. Aspergillus sp. microscopically characterized as septate and branched hyphae. Fungal corneal ulcers are more common in tropical climates. Aspergillus sp. is the most common fungi causes corneal ulcer. Risk factors include the use of antibiotics, long-term corticosteroids, trauma, contact lenses, and corneal surgery. 50-year-old female with main complaint: increased redness and pain of the right eye after trauma from twig. Palpebral edema, conjunctival injection, ciliary injection, corneal ulcers, maceration, and impending were found from physical examination of the right eye. Fungal culture on sabouraud dextrose agar (SDA) culture media found growth of fungi Aspergillus sp. which macroscopically has fertile hyphae on the surface and vegetative hyphae below the surface, and microscopically characterized as septate and branching hyphae. Corneal ulcers in the tropics are mostly caused by fungi. Aspergillus sp. and Fusarium sp. is most commonly found in tropical climates, while Candida is more commonly found in cold climates. Diagnosis of corneal ulcer ec Aspergillus sp. is obtained based on history, clinical manifestation and found Aspergillus sp. from fungal culture.

Correlation between Immature Platetet Fraction Value and SOFA Score in Sepsis Patient Hesty Rhauda Ashan; Husni Husni; Eugeny Alia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1883

Sepsis is a medical emergency that describes systemic inflammation reaction to infectious process that can lead to organ dysfunction and death. Sequential Organ Failure Assesment (SOFA) score is used to assess severity of organ dysfunction in septic patients. Immature platelet fraction (IPF) value can be used to evaluate thrombopoiesis. Research shows IPF can provide information regarding inflammatory activity and disease prognosis. A high IPF value in septic patient indicates the formation and recruitment of immature platelets that are triggered by infection. The aim of this study was to determine correlation between IPF value and SOFA score in sepsis patients. This was an analytical study with a cross-sectional design in 28 patients with sepsis who met the inclusion and exclusion criteria and conducted IPF tests at Central Laboratory of Dr M. Djamil Padang Hospital. The study was conducted from February 2020 to March 2021. Value of IPF was performed using automated hematology analyzer with flow cytometry method and SOFA scores are assessed by clinicians and obtained from medical records. Data were analyzed by Pearson correlation test, significant if p <0.05. Median value of IPF in patients with sepsis was 4.8 (1.4-15.7) %. Median of SOFA score in patients with sepsis was 5,5 (2-12). Correlation test showed a strong positive correlation between IPF values and SOFA score with r= 0.684 and p <0.05. There was a strong positive correlation between IPF values and SOFA score in sepsis.

Correlation between Immature Platetet Fraction Value and SOFA Score in Sepsis Patient Hesty Rhauda Ashan; Husni Husni; Eugeny Alia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1883

Sepsis is a medical emergency that describes systemic inflammation reaction to infectious process that can lead to organ dysfunction and death. Sequential Organ Failure Assesment (SOFA) score is used to assess severity of organ dysfunction in septic patients. Immature platelet fraction (IPF) value can be used to evaluate thrombopoiesis. Research shows IPF can provide information regarding inflammatory activity and disease prognosis. A high IPF value in septic patient indicates the formation and recruitment of immature platelets that are triggered by infection. The aim of this study was to determine correlation between IPF value and SOFA score in sepsis patients. This was an analytical study with a cross-sectional design in 28 patients with sepsis who met the inclusion and exclusion criteria and conducted IPF tests at Central Laboratory of Dr M. Djamil Padang Hospital. The study was conducted from February 2020 to March 2021. Value of IPF was performed using automated hematology analyzer with flow cytometry method and SOFA scores are assessed by clinicians and obtained from medical records. Data were analyzed by Pearson correlation test, significant if p <0.05. Median value of IPF in patients with sepsis was 4.8 (1.4-15.7) %. Median of SOFA score in patients with sepsis was 5,5 (2-12). Correlation test showed a strong positive correlation between IPF values and SOFA score with r= 0.684 and p <0.05. There was a strong positive correlation between IPF values and SOFA score in sepsis.

Performed Laparoscopic Surgery For Gastric Perforation: Case Report Mirton; Pasihulilzan; Ashan, Hesty Rhauda
Journal of Society Medicine Vol. 3 No. 6 (2024): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i6.147

Introduction: Perforated peptic ulcer (PPU) is a life-threatening disease with historically reported high morbidity and mortality rates. The epidemiology of perforated peptic ulcer was appear to be stable in recent. The laparoscopy as primary operation has focused on safety to tread PPU. Case: A 75 years old man presented to our emergency center with generalized abdominal pain since 2 days before admision. Generalize abdominal pain develop suddenly and severe. Patient has history taking NSAID for 7 years to treat pain in the knee joint. He was complaining of chronic and recurrent upper abdominal for 5 year and relieved by food or antacids. He is smoker. After initial resuscitation by adequate administration intravenous lines of fluid and nasogastric tube, Patient underwent a laparocopik surgery, we perform prymari suture and a Graham patch. We followed administration antibiotic and proton pump inhibitor. We perform the suturing to close the perforation site before peritoneal irrigation to avoid the accumulation of infected fluid and other debris. Once irrigation was complete, a large volume of omentum was reinforced above the primary suture site. Conclusion: We successfully managed perforated peptic ulcers with minimally invasive approach. Adequate resuscitation, hypotension in no longer be a significant prognostic indicator. In experienced hand laparoscopic is probably the most appropriate approach for perforated peptic ulcer. Because no upper abdominal incision is made, there I decreased post operative pain and decrease administration of post operative pain medication. The patient rapidly recovers with less complication.

Perbedaan Kadar Natrium pada Packed Red Cell Berdasarkan Lama Penyimpanan di Bank Darah RSUP Dr. M. Djamil Padang Ashan, Hesty Rhauda
Jurnal Kesehatan Andalas Vol. 9 No. 1 (2020): Online March 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i1.1237

Packed Red Cell (PRC) adalah komponen darah yang didapat setelah sebagian besar plasma dipisahkan dari Whole Blood (WB) dan memiliki nilai hematokrit sekitar 80%. Packed red cell disimpan pada suhu 2-6Â°C selama 21â€“42 hari tergantung larutan antikoagulan-pengawet yang digunakan. Pompa Na+/K+ATPase menjadi inaktif pada suhu 4Â°C menyebabkan natrium masuk ke dalam sel dan kalium keluar dari sel. Proses ini terjadi perlahan dan terus menerus sehingga kadar natrium pada plasma PRC menurun sesuai dengan bertambahnya waktu penyimpanan. Tujuan: Menentukan perbedaan kadar natrium PRC antara penyimpanan â‰¤14 hari dan >14 hari di bank darah RSUP Dr.M.Djamil Padang. Metode: Penelitian ini adalah suatu penelitian analitik dengan rancangan potong lintang, dimulai dari bulan September 2016 sampai Oktober 2018. Kadar natrium diperiksa dengan electrolyte analyzer. Analisis data menggunakan uji-t, bermakna bila p<0,05. Hasil: Rerata kadar natrium pada penyimpanan â‰¤14 hari adalah 150,5 (2,9)Â mmoL/L dan 143,3 (4,3) mmoL/L pada penyimpanan >14 hari. Terdapat perbedaan bermakna rerata kadar natrium PRC berdasarkan lama penyimpanan (p= 0,0001). Simpulan: Terdapat perbedaan kadar natrium PRC pada lama penyimpanan â‰¤14 hari dan >14 hari.Kata kunci: lama penyimpanan, jejas penyimpanan, natrium, packed red cell

Unveiling Burnout: How Psychological Well-Being and Quality of Life Shape Female Lecturers' Resilience Ambarsarie, Riry; Dinda, Rofifah; Saki, Vernonia Yora; Euleryn, Norevia; Ashan, Hesty Rhauda
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.29-34

Female lecturers are more vulnerable to burnout due to biological and emotional factors, as well as the dual roles they often manage. Psychological well-being (PWB) and quality of life (QOL) are critical factors that can influence the occurrence of burnout. This research aims to determine the relationship between PWB and QOL with the level of burnout syndrome among female lecturers at University of Bengkulu. This study employed an observational cross-sectional design, consisted of 86 female lecturers at the University of Bengkulu selected through stratified random sampling. The variables were assessed by using Ryff’s Psychological Well-Being Scale, WHOQOL-BREF questionnaire, and Maslach Burnout Inventory Educators Survey. Data were analyzed using univariate, bivariate and multivariate analysis. The results showed that the majority of respondents were aged 36-45 years (34.9%), married (83.7%), and held a Master's degree (68.6%), have a high PWB level (86%) with good QOL (58.1%) and have a mild burnout syndrome (91.9%). The Pearson chi-square test analysis results show p = 0.0001 (p ≤ 0.05) for both PWB and QOL. From the multiple linear regression analysis, it was found that both the PWB and QOL variables have a negative and significant effect on burnout syndrome among female lecturers. Each increase both PWB and QOL will reduces burnout by 0.255 (PWB) and 0.829 (QOL). With appropriate interventions, it is hoped that a healthier and more productive work environment can be created, supporting professional development and the emotional well-being of educators, especially with female lecturers.

ASPEK KLINIS DAN PEMERIKSAAN LABORATORIUM TALASEMIA B Rhauda, Hesty; Eka Putri, Dian
Jurnal Kesehatan Tambusai Vol. 4 No. 2 (2023): JUNI 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i2.15002

Talasemia ? merupakan suatu kelainan genetik yang ditandai oleh gangguan dalam sintesis hemoglobin, yaitu protein pembawa oksigen dalam darah. Kelainan ini dapat menyebabkan anemia yang berat dan memerlukan perhatian medis yang serius. Pemeriksaan klinis dan laboratorium memiliki peran penting dalam diagnosis dan pemantauan talasemia ?. Oleh karena itu, penelitian ini bertujuan untuk mengeksplorasi aspek klinis dan pemeriksaan laboratorium pada talasemia ?. Tujuan dari penelitian ini adalah untuk menyelidiki karakteristik klinis yang muncul pada pasien dengan talasemia ?, serta menganalisis hasil pemeriksaan laboratorium yang terkait dengan kondisi ini. Penelitian ini menggunakan desain penelitian observasional retrospektif. Data dikumpulkan melalui peninjauan catatan medis pasien talasemia ? yang ada di rumah sakit. Data yang terkumpul dianalisis secara deskriptif untuk mendapatkan gambaran tentang karakteristik klinis dan hasil pemeriksaan laboratorium pada pasien talasemia ?. Hasil penelitian ini menunjukkan bahwa terdapat berbagai aspek klinis yang sering terjadi pada pasien talasemia ?, seperti gejala anemia, pertumbuhan terhambat, dan gangguan pada organ-organ tubuh tertentu. Selain itu, hasil pemeriksaan laboratorium menunjukkan karakteristik spesifik, seperti penurunan kadar hemoglobin, peningkatan kadar zat besi, dan perubahan dalam distribusi sel darah merah. Analisis data juga mengungkapkan adanya hubungan signifikan antara tingkat keparahan talasemia ? dengan hasil pemeriksaan laboratorium tertentu, yang dapat memberikan petunjuk dalam pemantauan dan penanganan pasien.

PPAR-γ, but not KCNJ11, Is Associated with Type 2 Diabetes Mellitus Progression among First-Generation Offspring of Lembak Ethnicity in Bengkulu, Indonesia Dita, Diah Ayu Aguspa; Yunita, Elvira; Rizqoh, Debie; Ashan, Hesty Rhauda; Fahira, Dita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4448

Background: Genetic and environmental factors influence the onset and progression of type 2 diabetes mellitus (T2DM). Variants affecting peroxisome proliferator activated-receptor gamma (PPAR-γ) and potassium, inwardly rectifying channel subfamily J member 11 (KCNJ11) may alter insulin secretion and sensitivity. This study investigated the association between PPAR-γ and KCNJ11 gene expression and the risk of T2DM among first-generation (F1) offspring of T2DM patients of Lembak ethnicity in Bengkulu, Indonesia.Methods: A cross-sectional observational study was conducted from July to September 2024, recruiting 60 unrelated participants aged 18–40 years, all of whom were exposed to the neron tradition (high-sugar consumption). Gene expression of PPAR-γ and KCNJ11 was determined using real-time quantitative PCR (qRT-PCR).Results: F1 offspring of T2DM patients (n=30) had significantly (p<0.05) higher body weight (66.89±15.62 kg; p=0.008), body mass index (BMI) (23.55±3.46 kg/m2), HbA1C (6.55±1.25), random blood glucose levels (median 131 [75–371] mg/dl), and duration of neron consumption (median 3 [1–12] years) compared with controls (n=30). PPAR-γ expression differed significantly between group (1.60±2.91 vs 4.23±8.54; p=0.009), whereas KCNJ11 expression did not (0.79±0.76 vs 1.37±0.89; p=0.124). Multivariate analysis revealed no correlation between gene expression and the patients characteristic (p>0.05). Linear regression showed 30.4% of PPAR-γ and 45.8% of KCNJ11 variability.Conclusions: PPAR-γ expression is associated with T2DM onset among Lembak F1 offspring, whilst KCNJ11 expression is not. Multiple genetic and environmental factors likely contribute to disease progression. Screening for PPAR-γ expression may support interventions targeting insulin sensitivity and lipid metabolism.

Edukasi Harpenden Skinfold Caliper Dalam Perencanaan Nutrisi Gizi Atlet Pada Tenaga Pengajar Sekolah Keberbakatan Olahraga (SKO) Provinsi Bengkulu Dita, Diah Ayu Aguspa; Ashan, Hesty Rhauda; Ilahi, Bogy Restu; Prabowo, Andika
Jurnal Pengabdian Olahraga Masyarakat (JPOM) Vol 7, No 1 (2026): Maret 2026
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/jpom.v7i1.23757

Kebutuhan akan performa atlet yang optimal sangat erat kaitannya dengan status gizi dan komposisi tubuh yang ideal. Akan tetapi, masih rendahnya pemahaman tenaga pengajar mengenai perencanaan gizi yang tepat menjadi tantangan di Sekolah Keberbakatan Olahraga (SKO) Provinsi Bengkulu. Pelathan ini bertujuan untuk memberikan pelatihan penggunaan Harpenden Skinfold Caliper sebagai salah satu alat bantu dalam perencanaan nutrisi atlet. Metode Community-Based Participatory Research (CBPR) diterapkan dalam pelatihan kepada 30 tenaga pengajar. Hasil pelatihan menunjukkan peningkatan pengetahuan peserta terkait pengukuran lemak tubuh dan implikasi terhadap penyusunan pola nutrisi. Diharapkan pelatihan ini berkontribusi pada peningkatan kualitas pembinaan atlet daerah.

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