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All Journal Universa Medicina Jurnal Pengabdian Masyarakat Trimedika
Graciela, Audria
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HIGH DIETARY DAIDZEIN INTAKE LOWERS CHOLESTEROL LEVELS AMONG POST-MENOPAUSAL WOMEN Herwana, Elly; Pusparini, Pusparini; Graciela, Audria
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.588 KB) | DOI: 10.18051/UnivMed.2020.v39.47-54

Abstract

BackgroundMenopause is associated with changes in metabolic profile. Although hormone replacement therapy (HRT) has been shown to have beneficial effects on lipid metabolism, its adverse effects have indicated a need for alternative estrogen-based treatments. Several investigations have evaluated the effects of isoflavones on serum lipid levels in postmenopausal women, but the results were ambiguous. The objective of this study was to determine the relationship of dietary daidzein, genistein, and glycitein levels with lipid profile in postmenopausal women.MethodsA cross-sectional study was conducted involving 186 post-menopausal women. A food recall questionnaire was used to measure dietary genistein, daidzein, and glycitein levels. Serum total cholesterol (TC), low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triacylglycerol (TAG) were measured using the enzymatic colorimetric method. Simple and multivariate linear regression were used to analyze the data.ResultsGenistein intake was significantly associated with TC (b=145.48, p=0.023) and HDL cholesterol levels (b=48.80, p=0.032). Daidzein intake was significantly associated with TC (b=-204.60, p=0.003), LDL cholesterol (b=-160.81, p=0.014) and HDL cholesterol levels (b=-67.118, p=0.032). Glycitein was not significantly associated with TC (b=232.78;p=0.133), HDL (b=43.59;p=0.428), and LDL (b=235.84;p=0.116). Dietary daidzein had a more lowering effect on TC (Beta=-2.80) and HDL cholesterol (Beta=-2.67) than had genistein on TC (Beta=2.66) and HDL cholesterol (Beta=2.03).ConclusionsHigh dietary daidzein level has a significant lowering effect on TC, LDL cholesterol and HDL cholesterol in post-menopausal women. Our study supports the advice given to the public to increase soy isoflavone intake in post-menopausal women.
SKRINING HIPERGLIKEMIA DAN PELATIHAN MANAJEMEN DIRI PENGENDALIAN GULA DARAH PADA DIABETES MELITUS Herwana, Elly; Yenny, Yenny; Kurniasari, Kurniasari; Kalumpiu, Joice Viladelvia; Alvina, Alvina; Soesanto, Sheila; Graciela, Audria
Jurnal Pengabdian Masyarakat Trimedika Vol. 2 No. 1 (2025)
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/abdimastrimedika.v2i1.22106

Abstract

Diabetes mellitus (DM) is a chronic disease with a high prevalence throughout the world. Chronic hyperglycemia in DM increases the risk of complications in kidney function disorders, stroke, heart diseases, and retinopathy, which will impact to a high economic burden and decrease the quality of life in DM patients. Early detection of DM, optimal management by administering antidiabetic drugs and continuous self-management of blood sugar control will reduce the risk of DM complications. This activity was carried out with the aim of early detection of DM and to increase knowledge about DM, self-management, controlling hyperglycemia, and the risk of DM complications. Early detection screening for DM was carried out by measuring the respondent's blood sugar levels in the morning. Increasing knowledge about DM is carried out through training, counseling and interactive questions and answers with respondents. Screening for blood sugar levels found that 8 respondents (26.7%) suffered from DM. The distribution of body mass index (BMI), systolic, and diastolic blood pressure did not show significant differences between DM and non-DM respondents. Training and counseling about DM had the impact of increasing the level of respondent’s knowledge by 13.4% (83.3% vs 96.7%) so this training is expected to be useful in reducing the risk of complications for DM patients
Co-Authors Alvina Alvina Elly Herwana, Elly Joice Viladelvia Kalumpiu, Joice Viladelvia Kurniasari Kurniasari, Kurniasari Pusparini Pusparini Soesanto, Sheila YENNY YENNY