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All Journal Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Asian Journal of Health Research
Alim, Fathi Nabila
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EFEK PAPARAN PROFILIN Toxoplasma gondii TERHADAP KADAR CHEMERIN PADA TIKUS Rattus norvegicus STRAIN WISTAR Iskandar, Agustin; Mayashita, Dearikha Karina; Alim, Fathi Nabila
Majalah Kesehatan FKUB Vol 5, No 4 (2018): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.639 KB) | DOI: 10.21776/ub.majalahkesehatan.005.04.1

Abstract

 Obesitas merupakan masalah kesehatan masyarakat global yang terkait dengan morbiditas, mortalitas, dan keterbatasan fungsional.  Di saat yang bersamaan, prevalensi penyakit menular karena infeksi juga menunjukkan adanya peningkatan. Hal ini menimbulkan dugaan adanya keterkaitan antara infeksi dengan obesitas. Profilin merupakan bagian dari parasit Toxoplsma gondii yang dapat berikatan dengan TLR-11 dan  memicu ekspresi IL-12 serta sitokin proinflamasi lain, yang diduga dapat menyebabkan obesitas. Penelitian ini bertujuan untuk mengetahui efek paparan profilin T. gondii terhadap kadar chemerin sebagai adipositokin proinflamasi. Penelitian ini merupakan penelitian eksperimental laboratorium dengan rancangan true eksperimental-post test only control group design, menggunakan tikus (Rattus norvegicus) strain Wistar, yang diberi dua perlakuan yakni diet normal dan diet hiperkalori. Kemudian diinjeksi profilin dosis 15, 30, 45 mcg/mL.  Hasil penelitian menunjukkan adanya perbedaan kadar chemerin yang signifikan (p = 0,038; ). Hasil uji post-hoc Tukey  didapatkan perbedaan bermakna pada kelompok profilin dengan dosis 30 mcg/mL yang diberi diet hiperkalori. Uji kolerasi dan regresi linier pada kelompok diet normal menunjukkan hubungan yang kuat antara dosis profilin dengan kadar chemerin (r = 0,600) dan R2 = 0,360 yang dapat diartikan bahwa ada pengaruh dosis profilin pada kenaikan kadar chemerin yaitu sebesar 36%. Pada kelompok diet hiperkalori didapatkan hubungan sangat kuat antara dosis profilin dengan kadar chemerin (r = 0,078) dan R2 = 0,609 yang berarti  bahwa pengaruh dosis profilin pada kenaikan kadar chemerin sebesar 60,9%. Kesimpulan penelitian ini adalah paparan profilin Toxoplasma gondii menyebabkan peningkatan kadar chemerin pada tikus strain Wistar. 
Therapeutic Strategies in the Treatment and Prevention of Preterm Labor: A Systematic Review Alim, Fathi Nabila; Hariyati, Suheni Ninik
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.242

Abstract

Introduction: Prematurity remains the leading cause of prenatal and newborn mortality and morbidity worldwide. Numerous trials with varying degrees of efficacy have been carried out to identify therapies to prevent premature birth. Therefore, the purpose of this study is to analyze the efficacy of medications with different dosages that have been previously studied in terms of their ability to delay premature labor.    Material and Methods: The authors searched for randomized-controlled trials (RCTs) that addressed the use of therapy to prevent or treat preterm birth in pregnant patients who were either diagnosed with or at risk for preterm birth. The PRISMA approach was used to conduct the search using electronic databases, including Embase, ProQuest, PubMed, and Cochrane.    Results: We obtained 34 RCTs that met the inclusion criteria. We discovered that 400 mg of progesterone administered intravaginally consistently had a substantial effect in postponing preterm birth. Other kinds of aspirin, such as 60 mg and 81 mg, are effective in postponing premature birth. In addition, taking supplements of docosahexaenoic acid (omega-3 fatty acid) throughout pregnancy considerably delays premature birth. Preterm labor is also markedly delayed in pregnant women with HIV when selenium supplements are taken.    Conclusion: Intravaginal progesterone, oral low dose aspirin, and docosahexaenoic acid supplementation have the potential to be therapies to prevent preterm labor.
Maternal profiles and outcome of Placenta Accreta Spectrum (PAS) in a retrospective cohort study in Dr. Saiful Anwar General Hospital, Malang, Indonesia Rahardjo, Bambang; Pratama, Harry Dwi; Purbandari, Rosalia; Alim, Fathi Nabila
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.204-213

Abstract

HIGHLIGHTS This study compares maternal characteristics and outcomes between PAS and non-PAS patients, including analysis using the Placenta Accreta Index. PAS is associated with significantly higher intraoperative blood loss and postoperative ICU admission rates. Findings underscore the importance of early identification and PAI-based risk stratification to optimize surgical planning and maternal outcomes.   ABSTRACT Objective: This study aims to investigate maternal risk factors associated with PAS among patients at Dr. Saiful Anwar Regional General Hospital in Malang. Materials and Methods: This retrospective cohort study was conducted at RSUD Dr. Saiful Anwar Malang, analyzing medical records of patients diagnosed with Placenta Accreta Spectrum (PAS) from January 2023 to August 2024. Patients were categorized into PAS and non-PAS groups, with further classification of PAS patients based on their Placenta Accreta Index (PAI) score (<5 and ≥5) to compare clinical outcomes. A total of 47 eligible patients were included based on gestational age ≥28 weeks, clinical suspicion of PAS, and histopathological confirmation. Demographic, clinical, intraoperative, and postoperative data were collected and analyzed. Data were analyzed using SPSS 27.0. Ethical approval was obtained from the RSUD Dr. Saiful Anwar Ethics Committee. Results: Patients with PAI scores ≥5 had higher intraoperative blood loss (3467.50 ± 2520.35 mL) compared to those with PAI scores <5 (2212.50 ± 1055.32 mL, p=0.764). Hysterectomy was the primary surgical approach in both groups (PAI <5: 88.88%, PAI <5: 92.75%, p=0.667). Bladder trauma (AAST grade IV) occurred in 100% of patients with PAI <5, whereas bladder infiltration was observed only in the PAI ≥5 group (p=0.117). NICU admission was more frequent in the PAI ≥5 group (31.25% vs. 0%, p=0.061). ICU admission was required in all PAI <5 patients (100%) and 75% of PAI <5 patients (p=0.102). No statistically significant associations were found. Conclusion: Higher PAI score may indicate a more complex clinical course, further research with larger sample sizes is necessary to validate its predictive value.
Co-Authors Agustin Iskandar Bambang Rahardjo Hariyati, Suheni Ninik Mayashita, Dearikha Karina Pratama, Harry Dwi Purbandari, Rosalia