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All Journal Majalah Obstetri dan Ginekologi Asian Journal of Health Research
Hariyati, Suheni Ninik
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Influence of Vitamin D3 Supplementation on LH and FSH Levels in Female Rats (Rattus norvegicus) with Polycystic Ovary Syndrome (PCOS) Model Gandhari, Anak Agung Sagung Agung Ayuska; Wiyasa, I Wayan Arsana; Hariyati, Suheni Ninik; Baihaqi, Irfani
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.133

Abstract

Introduction: Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder in reproductive-aged women, characterized by hormonal imbalances such as Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This study investigates the impact of Vitamin D3 supplementation on LH and FSH levels in female rats with a PCOS model. Material and Methods: In this laboratory experiment, female rats were induced with testosterone propionate for 28 days. They were divided into three groups: negative control, positive control (testosterone only), and treatment (testosterone + Vitamin D3 supplementation). LH and FSH levels were measured using the enzyme-linked immunosorbent assay method. Results: The results revealed that Vitamin D supplementation significantly reduced FSH levels in the treatment group compared to the positive control, while it increased FSH levels. Regression analysis demonstrated a negative correlation between Vitamin D supplementation and LH levels, as well as a positive correlation with FSH levels. Conclusion: Vitamin D3 supplementation appears to have a regulatory effect on LH and FSH levels in female rats with PCOS. Future research could explore the impact of higher Vitamin D3 doses and conduct further investigations at advanced stages of PCOS. These findings contribute to our understanding of PCOS and potential interventions involving Vitamin D3.
MicroRNAs obtained from cervical swabs in predicting preterm birth Purbandari, Rosalia; Hariyati, Suheni Ninik
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.207-213

Abstract

HIGHLIGHTS Increased expression of certain miRNAs in women experiencing preterm birth could be linked to various molecular pathways which contributes to preterm birth. miRNAs obtained from cervical swabs exhibit statistically significant difference in expression between women with term births and preterm births.   ABSTRACT Objective: Identifying the risk of preterm birth is crucial for early intervention. miRNAs, small non-coding RNAs that regulate gene expression, play a key role in development and tissue maintenance. Under stress conditions, their regulatory functions become significant, linking them to disease states. Using miRNAs from cervical swabs as potential biomarkers could revolutionize preterm birth risk assessment. This systematic review examines current research on the effectiveness of cervical swab miRNAs in predicting and estimating preterm birth risks, aiming to enhance early detection and management strategies for preterm births. Materials and Methods: Using PubMed database, 14 articles were obtained using the keywords “microRNA” and “preterm”. Reviews and unrelated studies were then excluded from both pooled articles, resulting in 4 articles included in the final review. Risk of bias were examined using the Newcastle Ottawa Scale. Sample characteristics, time of cervical swab collection, and results from each study were extracted for further analysis. Results: A total of 4 articles were included in this review. Various miRNAs were examined in and were generally successful in predicting preterm birth. miRNA-145, miRNA-199, miRNA-30, miRNA-21, and miRNA-181 family were examined by multiple studies and produced significant results in predicting preterm birth. Based on enrichment analysis, various miRNAs were found to be involved in several biomolecular signaling pathways leading to preterm birth, such as inflammation, chemokine and cytokine signaling pathway, and toll-like receptor signaling. Conclusion: miRNAs obtained from cervical swabs exhibit statistically significant difference in expression between women with term births and preterm births. Further studies are needed to improve the predicting power and accuracy of miRNAs in preterm births.
Pregnancy With Severe Thrombocytopenia Caused by HELLP Syndrome and Acute Idiopathic Thrombocytopenic Purpura: a Case Report Widowati, Ayu Rizky; Firdaus, Wildan Aulia; Hariyati, Suheni Ninik; Hermanto, Djoko Heri
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.183

Abstract

Introduction: Thrombocytopenia in pregnancy could result in a wide range of prognosis, with the worst-case being life-threatening. Thrombocytopenia in pregnancy is a rare condition which could result in bleeding, endangering both maternal and foetal components. During pregnancy, thrombocytopenia could be caused by various factors, including idiopathic thrombocytopenic purpura and preeclampsia. Case Presentation: A 28-year-old pregnant woman, primigravid, gestational age 37-38 weeks old, single pregnancy, presents with fever ongoing for 12 days. A routine blood test returned a thrombocyte count of 11000/mm3. Patient received 8 units of thrombocyte concentrate with no improvement and progressive decline of thrombocyte count. Patient was assessed with severe thrombocytopenia caused by suspected dengue fever, with differential diagnoses being HELLP syndrome and idiopathic thrombocytopenic purpura. Patient was also assessed with severe preeclampsia and severe oligohydramnios. Patient’s condition improved after termination of pregnancy by caesarean section, accompanied with gradual return to normal thrombocyte count value. Conclusion: Thrombocytopenia in pregnancy could be caused by various factors, necessitating the need for a thorough medical evaluation to determine the underlying cause. A multidisciplinary and collaborative approach is highly recommended in managing pregnant women with thrombocytopenia.
Therapeutic Strategies in the Treatment and Prevention of Preterm Labor: A Systematic Review Alim, Fathi Nabila; Hariyati, Suheni Ninik
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.242

Abstract

Introduction: Prematurity remains the leading cause of prenatal and newborn mortality and morbidity worldwide. Numerous trials with varying degrees of efficacy have been carried out to identify therapies to prevent premature birth. Therefore, the purpose of this study is to analyze the efficacy of medications with different dosages that have been previously studied in terms of their ability to delay premature labor.    Material and Methods: The authors searched for randomized-controlled trials (RCTs) that addressed the use of therapy to prevent or treat preterm birth in pregnant patients who were either diagnosed with or at risk for preterm birth. The PRISMA approach was used to conduct the search using electronic databases, including Embase, ProQuest, PubMed, and Cochrane.    Results: We obtained 34 RCTs that met the inclusion criteria. We discovered that 400 mg of progesterone administered intravaginally consistently had a substantial effect in postponing preterm birth. Other kinds of aspirin, such as 60 mg and 81 mg, are effective in postponing premature birth. In addition, taking supplements of docosahexaenoic acid (omega-3 fatty acid) throughout pregnancy considerably delays premature birth. Preterm labor is also markedly delayed in pregnant women with HIV when selenium supplements are taken.    Conclusion: Intravaginal progesterone, oral low dose aspirin, and docosahexaenoic acid supplementation have the potential to be therapies to prevent preterm labor.
Co-Authors Alim, Fathi Nabila Baihaqi, Irfani Firdaus, Wildan Aulia Gandhari, Anak Agung Sagung Agung Ayuska hermanto, djoko heri Purbandari, Rosalia Widowati, Ayu Rizky Wiyasa, I Wayan Arsana