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Deka, Debasish
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Medicine & Pharmacology

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MICROSPHERE: A PROMISING APPROACH FOR DRUG DELIVERY Choudhury, Ananta; Deka, Debasish; Sonowal, Kashmiri; Laskar, Rahela Eyachmin
Journal of Applied Pharmaceutical Research Vol 7 No 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.001

Abstract

The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 ?m to 1000 ?m (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API.  It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day?s microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
Microsphere: a promising approach for drug delivery Choudhury, Ananta; Deka, Debasish; Sonowal, Kashmiri; Laskar, Rahela Eyachmin
Journal of Applied Pharmaceutical Research Vol. 7 No. 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.444 KB) | DOI: 10.18231/j.joapr.2019.001

Abstract

The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 μm to 1000 μm (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API. It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day’s microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
Liposome: a carrier for effective drug delivery Choudhury, Ananta; Sonowal, Kashmiri; Laskar, Rahela E; Deka, Debasish; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 8 No. 1 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.688 KB) | DOI: 10.18231/j.joapr.2019.v.8.i.1.003

Abstract

Liposomes are the spherical vesicles containing one or more phospholipid bilayer, which was first described in the middle of 60s by Bangham. The bilayer vesicles are considered as an efficient carrier for drug delivery, diagnostic agents, and also an effective tool for vaccine delivery. Liposome has been used as a potential carrier for several diseases from cardiovascular disease to bacterial infection and also it has the ability to reducing the toxicity of highly potent drugs and simultaneously utilized to improve pharmacokinetics and therapeutic efficacy. A liposome is a formulation which has the capacity to overcome with the limitation of conventional therapies. For the delivery of liposome ocular and inhalation route are some advanced technology. In poorly water soluble substance pulmonary delivery is very much useful. However liposome based vaccines have been demonstrated in clinical trials and further progress in human trails. This review discusses the mechanism of action, Method of preparation, evaluation, application of liposomal drug delivery system along with the recent developments some of the commercially available products.
Co-Authors Ananta Choudhury, Ananta Dey, Biplab Kumar Laskar, Rahela E Laskar, Rahela Eyachmin Sonowal, Kashmiri