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Dey, Biplab Kumar
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Medicine & Pharmacology

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FLOATING DRUG DELIVERY SYSTEM: AN OUTLOOK Dey, Biplab Kumar; Choudhury, Ananta; Renthlei, Lalmalsawmi; Dewan, Manjima; Ahmed, Raju; Barakoti, Himal
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.003

Abstract

Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The floating drug delivery approach is a low-density system that may be effervescent or Non-Effervescent type with sufficient buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. Floating dosage forms include tablets, granules, capsules, microspheres, microparticle, etc. are few formulations available commercially. A comprehensive summary of different floating drug delivery and its present status has been highlighted in this review.
Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum l. Basak, Mrinmoy; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 4 No. 2 (2016)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.403 KB)

Abstract

In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of H. indicum were collected from different part of Assam and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Phytochemical screening has been done by standard procedure and showed the presence of alkaloids, glycoside, carbohydrate, phytosterol, flavonoids and saponins and absence of fixed oil and gums-mucilage. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of H. indicum 250 and 500 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with H. indicum extract at a dose of 250, 500 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 500 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25mg/kg and tested drug H. indicum extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.
Pharmacognostical, phytochemical and anthelmintic activity of Polygonum muricatum Goswami, Priyanka; Islam, Rajibul; Khongmalai, Everlasting; Sarkar, Bapi Ray; Sen, Saikat; Choudhury, Ananta; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 6 No. 3 (2018)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.541 KB) | DOI: 10.18231/2348-0335.2018.0009

Abstract

Polygonum muricatum is widely used by the local people of Meghalaya for anthelmintics. An attempt has been made to evaluate the pharmacognostical, preliminary phytochemical and pharmacological parameters of leaves of Polygonum muricatum. The physicochemical constants like moisture content, ash values such as total ash, acid insoluble ash and water soluble ash, extractive values such as water soluble extractive value and alcohol soluble extractive value were determined. The extract obtained by successive solvent extraction was subjected to preliminary phytochemical analysis to find out the presence of compounds. The plant Polygonum muricatum leaves were extracted with the solvent benzene, acetone, ethanol and water by soxhlet apparatus method. The extract was evaluated for anthelmintic activity with Indian earthworm. Ethanol extract of the plant Polygonum muricatum has shown the significant activity.
Floating drug delivery system: an outlook Choudhury, Ananta; Renthlei, Lalmalsawmi; Dewan, Manjima; Ahmed, Raju; Barakoti, Himal; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 7 No. 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (496.947 KB) | DOI: 10.18231/j.joapr.2019.003

Abstract

Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The floating drug delivery approach is a low-density system that may be effervescent or Non-Effervescent type with sufficient buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. Floating dosage forms include tablets, granules, capsules, microspheres, microparticle, etc. are few formulations available commercially. A comprehensive summary of different floating drug delivery and its present status has been highlighted in this review.
Autism: a curse on today’s society Sarkar, Snehashis; Choudhury, Ananta; Saha, Suman; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 8 No. 1 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.39 KB) | DOI: 10.18231/j.joapr.2019.v.8.i.1.001

Abstract

Autism is a group of neurodevelopment disorders characterized by impaired communication, impaired social interaction and restricted, repetitive and stereotyped patterns of behaviours or interests in the first 3 years of life. It shows a strong male bias and found four times more in males than in females. According to a study in the US, in 2014, overall 1.68% of victims were reported to have Autism Spectrum Disorder (ASD), whereas the percentage was increased by 15% and 150% respectively over the year 2012 and 2000. Numerous genes have been discovered that have roles in ASD but still a good understanding of the pathophysiological process of ASD is not established. ASD costs are estimated to be approximately $250 billion annually in the U.S. Moreover, it is suggested that by 2025, ASD costs will rise to over $450 billion. Thus, the financial burden on families is increasing. There is no effective screening tool for proper diagnosis is available. Based on Infant Toddler Checklist (ITC) and Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) some tests like ADOS-G, ADI-R, CARS etc. are used for diagnosis. There are medications to cure symptoms but no single medication for ASD. However, some therapies (like ABA- Applied Behavioural Analysis, DTT- Discrete Trial Training, and Symptomatic treatments, etc.) are there that show positive responses towards improvement from a disease state. Some crucial advancement has been achieved in the last decades. Here in the work we have focused on the diagnostic methods and treatment available for the symptoms of Autism. So, it can be said that the day is not too far away when the remedy to cut the curse of autism will be in our hands.
Liposome: a carrier for effective drug delivery Choudhury, Ananta; Sonowal, Kashmiri; Laskar, Rahela E; Deka, Debasish; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 8 No. 1 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.688 KB) | DOI: 10.18231/j.joapr.2019.v.8.i.1.003

Abstract

Liposomes are the spherical vesicles containing one or more phospholipid bilayer, which was first described in the middle of 60s by Bangham. The bilayer vesicles are considered as an efficient carrier for drug delivery, diagnostic agents, and also an effective tool for vaccine delivery. Liposome has been used as a potential carrier for several diseases from cardiovascular disease to bacterial infection and also it has the ability to reducing the toxicity of highly potent drugs and simultaneously utilized to improve pharmacokinetics and therapeutic efficacy. A liposome is a formulation which has the capacity to overcome with the limitation of conventional therapies. For the delivery of liposome ocular and inhalation route are some advanced technology. In poorly water soluble substance pulmonary delivery is very much useful. However liposome based vaccines have been demonstrated in clinical trials and further progress in human trails. This review discusses the mechanism of action, Method of preparation, evaluation, application of liposomal drug delivery system along with the recent developments some of the commercially available products.
Co-Authors Ahmed, Raju Ananta Choudhury, Ananta Barakoti, Himal Deka, Debasish Dewan, Manjima Goswami, Priyanka Islam, Rajibul Khongmalai, Everlasting Laskar, Rahela E Mrinmoy Basak, Mrinmoy Renthlei, Lalmalsawmi Sarkar, Bapi Ray Sarkar, Snehashis Sen, Saikat Sonowal, Kashmiri Suman Saha, Suman