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Silitonga, Hendrika Andriana
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Medicine & Pharmacology Public Health

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Does HBA1C Correlate with Lipid Profile in Type 2 Diabetes Mellitus? A New Evidence from Medan, North Sumatera Julianto, Endy; Silitonga, Hendrika Andriana; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 3 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Diabetes mellitus (type 2 DM) is now ranked first in health problems and its prevalence tends to increase worldwide. The Diabetes Control and Complication Trial (DCCT) study showed that lowering HbA1c rates may delay or prevent chronic complications. One of the risk factors for CHD in type 2 DM is dyslipidemia, i.e lipid metabolism disorders in the form of elevated total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and decreased levels of high-density lipoprotein (HDL). This study aimed to determine the correlation between HBA1C and blood sugar, as well as the lipid profile in patients with type 2 DM.Subject and Methods: This was an analytic observational study with a cross-sectional design. The study was conducted at the Endocrinology and Metabolic polyclinic Pirngadi Hospital, Medan, North Sumatera, from January to February 2018. A total sample of 10 patients diagnosed with type 2 diabetes mellitus with obesity was selected for this study. The independent variables were blood sugar, lipid profile including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. The dependent variable was the HbA1c level. Lipid profile was measured by blood serum examination. HbA1c level was measured by blood serum examination. The data were analyzed by Pearson correlation.Results: Hba1c was positively correlated with blood sugar levels and was statistically significant (r= 0.81; p= 0.005). HbA1c correlated weakly and was statistically non-significant with total cholesterol (r= 0.14, p= 0.702), LDL (r= 0.15; p= 0.683), HDL (r= 0.04; p= 0.922), and triglycerides (r= 0.06; p= 0.860).Conclusion: HbA1c correlates with blood sugar levels but does not show a correlation with lipid profiles.Keywords: HBA1C, lipid profile, blood sugar, type 2 diabetes mellitusCorrespondence:Endy Julianto. Department of Parasitology, Faculty of Medicine, Methodist University, Medan.Indonesian Journal of Medicine (2017), 2(3): 207-212https://doi.org/10.26911/theijmed.2017.02.03.08
THE EFFECTS OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTIONATION OF SECHIUM EDULE JACQ. SWARTZ ON TRIGLYCERIDE LEVELS IN MALE RATS WITH TYPE 2 DIABETES MELLITUS Siahaan, Jekson Martiar; Julianto, Endy; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: The prevalence of diabetes mellitus (DM) from year to year is increasing. Hyper­glycemia that occurs in DM is caused by oxidative stress that damages pancreatic ? cells. This situation can be controlled with synthetic hypoglycemic drugs, but it requires high medical costs. Therefore, alternative therapies that are easily available, relatively inexpensive, have potential anti-hypoglycemia and anti-cholesterolemia which is found in conjoined flasks (Sechium edule (Jacq.) Swartz) which contains flavonoids are needed. The purpose of this study was to analyze the effectiveness of ethanol extract and fractionation of ethyl acetate extracts of Sami (pumpkin) (Sechium edule (Jacq.) Swartz) as anti-hipoglycemia and anti-hypertriglycerides in white male wistar rats (Rattus novergius sp.) induced by STZ-NA-HFDD.Subjects and Method: A randomized controlled trial was conducted to assess the effectiveness of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract. The sample included white male wistar rats (Rattus novergius sp.) Hyperglycemia induced by STZ-NA-HFD. The dependent variable was triglyceride levels. The independent variables were administration of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract.Results: Ethyl acetate fraction 45 mg/kgBW better reduce triglyceride levels but statistically does not have significant differences between groups.Conclusion: The group that received Metformin and the group that was given ethanol extract 45 mg/kgBW had lower triglyceride levels compared to the other therapy and control groups.Keywords: Hipertrigliseridemia, diabetes mellitus, STZ-NA-HFDCorrespondence: Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: Jekson.siahaansked­@­gmail.comIndonesian Journal of Medicine (2019), 4(4): 371-375https://doi.org/10.26911/theijmed.2019.04.04.10 
The Effectiveness of Albendazole-Levamisole and Mebendazole-Levamisole on the Intensity of Trichuris trichiura Infection in Elementary School Children Anto, Endy Juli; Siahaan, Jekson Martiar; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Trichuris trichiura worm infec­tion is still a major public health problem in Indo­­nesia, especially in peripheral areas. Until now, the search for antihelmintic combinations that have a high healing ability against T. tri­chi­ura infections and in the search for truly effective worm­ing is still being done. Albendazole and Mebendazole single doses still show limited ef­fi­ca­cy in the treatment of T. trichuria worms. The combination of Albendazole with Levamisol can increase effectiveness, but this combination still needs further investigation. Based on that fact, it is necessary to study the effectiveness compa­rison of the degree of infection intensity between the treatment of Albendazol-Levamisol and Me­ben­dazol-Levamisol against T. trichiura.Subjects and Method: A double blind ran­domized control trial was conducted at the State Elementary School in Medan, North Sumatera, from April to October 2019. A sample of 60 children was selected for this study. The depen­dent variable was the number of eggs decreased, the cure rate, and side effects. The independent variables were Albendazole 400 mg-Levamisol 50 mg/ 100 mg and Mebendazole 500 mg-Levamisol 50 mg/100 mg. The stools of elementary school children were examined using the Kato-Katz method to find eggs of T. trichiura infection. Data analysis was performed using the Chi square test. Results: Samples in the Albendazol-Levamisol and Mebendazol-Levamisol groups were 30 children, respectively. Children infected with T. trichiura consisted of 58 children of mild in­tensity (96.7%) and 2 children of moderate inte­nsity (3.3%). On the results of stool examination, a significant difference in the number of eggs decreased in the two groups was obtained (p <0.001) and 96.7% was the cure rate for T. trichiura infection in the two groups of Alben­dazol-Levamisol and Mebendazol-Levamisol. In this study, there were no significant differences in side effects in the two treatment groups.Conclusion: Treatment of T. trichiura infection with single doses of Albendazol-Levamisol and Mebendazol-Levamisol showed that there were sig­nificant differences in the Number of D­ecreased Eggs. Meanwhile, for the cure rate, there was no difference between the Albendazol-Levamisol and Mebendazol-Levamisol groups.Keywords: T. trichiura, Albendazole-Levamisol, Mebendazole-LevamisolCorrespondence: Endy Juli Anto. Department of Parasitology, Faculty of Medicine, Universitas Methodist In­donesia, Medan, Indonesia. Email: dr.endy­julianto@gmail.com. Mobile: +62-823 6766-7575Indonesian Journal of Medicine (2020), 5(1): 17-23https://doi.org/10.26911/theijmed.2020.05.01.03
The Effectiveness of Ethanol Extract Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on Pancreatic β-Cell Diameter of Male White Rats Wistar Strain with Type 2 Diabetes Mellitus Hutagalung, Sanggam Bangun; Siahaan, Jekson Martiar; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Diabetes Mellitus is character­rized by metabolic disturbances due to pro­longed hyperglycemia, causing oxidative stress, which destroys pancreatic β cells. Adjuvant therapy that has antihyperglycemic effective­ness and is required to improve the diameter of pancreatic beta cells, one of which comes from Sechium edule (Jacq.) Swartz has poten­tial as an antihyperglycemic, antioxidant, anti­apop­tosis, cardioprotective, insulin resistance. This study aimed to examine the effectiveness of ethanol extract, Chayote (Sechium Edule (Jacq.) Swartz) fraction, and juice on the pancreatic β-cell diameter of white male rats Wistar strain with type 2 diabetes mellitus.Subjects and Method: This was a rando­mized controlled trial. Sample was Rattus novergius sp. 54 tails. The dependent variable was the diameter of the pancreatic β cells. The independent variables were ethanol extract, Sechium edule (Jacq.) Swartz fraction and juice, at a dose of 50 mg/kg BW, 100 mg/ kg BW, 150 mg/kg BW. The data were analyzed by the ANOVA test.Results: The group of mice induced by Strep­tozotocin 50 mg/kg BW + nicotinamide (120 mg/ kg BW) + HFD and obtained ethanol extract of chayote fruit 150 mg/ kg BW, orally, had the highest pancreatic β cell diameter com­pared to the other groups (Mean= 284.03; SD= 5.15).Conclusion: Sechium edule (Jacq.) Swartz has potential as an anti-apoptosis that can inhibit pancreatic β cell damageKeywords: pancreatic β cells, anti-apoptosisCorrespondence: Sanggam Bangun Hutagalung. Department of Anatomical Pathology, Faculty of Medicine, Universitas Methodist Indonesia, Medan. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: sanggam1973@­gmail.com.Indonesian Journal of Medicine (2021), 06(03): 239-245https://doi.org/10.26911/theijmed.­2021.06.03.01 
Co-Authors Edwin Anto Pakpahan Endy Juli Anto Hutagalung, Sanggam Bangun Sembiring, Budi Darmanta Siahaan, Jekson Martiar