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Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L. Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Streptozotocin as diabetogenic can damage the pancreatic β cells of animals tried through the oxidative stress process to increase blood sugar levels. Giving ethanolic extract of squash fruit has hypoglycemia effect because it contains flavonoids that act as antioxidants and antihiperglichemia. This study aimed is analyze the effect of ethanol extract of squash fruit to decrease blood sugar level and the change of pancreatic β cell diameter.Subjects and Method: This study was an experimental study with post-randomized controlled group design, using male white mice (Mus musculus L.) DD Webster strains randomized into 4 groups: negative control group, positive control group, group with extract ethanol of 100 mg/ kgBB, and a group of ethanol extract of 200 mg/ kgBW of pumpkin.Results: The results showed a significant reduction in blood sugar levels if compared with the control group. The presence of changes in β pankreas cell diameter on ethanol extract of 100 mg/ kgBB and 200 mg/ kgBB.Conclusion: The conclusion of this study is the extract of ethanol fruit of 200mg/ kgBB squash significantly reduce blood sugar level of mice, the change of β pankreas cell diameter on ethanol extract of 100mg/ kgBB and 200mg/ kgBB.Keywords: streptozotocin, antihipoglikemia, flavonoidCorrespondence: Jekson Martiar Siahaan. Physiology Teaching Staff ofMedicine Faculty, Methodist University of Indonesia Medan, Jl. Setia Budi Pasar 2, Medan 20132, Indonesia.Journal of Medicine (2017), 2(2): 86-93https://doi.org/10.26911/theijmed.2017.02.02.02
Effect of Ethanol Extract of Chayote (Sechiumedule.Jacq.Swartz) on the Activity of Glutathione Peroxide (GPx) in House Mice (Musmusculus L) Strain DD Webster Hyperglycemia Induced by Streptozotocin (STZ) Siahaan, Jekson Martiar; Harahap, Urip; Loesnihari, Ricke
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic b cells. Ethanol extract of chayote can decrease oxidative stress.  This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content and increasing the activity of glutathione peroxide enzyme. Subjects and Method: This was an experimental study. The samples were using random sampling technique. The control group was using male white mice (Musmusculus L.) Strain DD Webster which randomized into four groups: negative control group, positive control group, group which got EEBLS of 100 mg/kgBB, and group which got EEBLS of 200 mg/kgBB.Results: The result of the research showed that there was significant decrease in blood sugar, compared with the control group. There was insignificant decrease in the activity of glutathione peroxide enzyme, compared with the control group.Conclusion: The conclusion of the research was that EEBLS of 200 mg/kgBB decreased blood sugar content of mice significantly, but there was no significant change in the activity of glutathione peroxide enzyme when EEBLS was given to the mice.   Keywords: streptozotocin, oxidative stress, antioxidant, flavonoidCorrespondence: Jekson Martiar Siahaan. Biomedical Science, Faculty of Medicine, North Sumatera University.Indonesian Journal of Medicine (2016), 1(1): 44-49https://doi.org/10.26911/theijmed.2016.01.01.06
Factors Associated with Tuberculosis in Deli Serdang, North Sumatera Syahputra, Fahmi; Parhusip, Rudolf S.; Siahaan, Jekson Martiar
Journal of Epidemiology and Public Health Vol 4, No 1 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Tuberculosis (TB) is still a major public health problem in most developing countries and its incidence is rising in many developed countries. This study aimed to examine factors associated with tuberculosis in Deli Serdang, North SumateraSubjects and Method: This was a cross-sectional study conducted in Deli Serdang, North Sumatera. A sample of 190 study subjects was selected for this study comprising of 95 TB patients and 95 non-TB patients. The dependent variable was tuberculosis. The independent variables were sex, education, BCG immunization, smoking, nutritional status, and dwelling density. Data on TB status were taken from medical record. The other variables were measured by questionnaire. The data were analyzed by a multiple logistic regression.Results: The risk of TB decreased with female sex (OR= 0.33; 95% CI= 0.11 to 0.98; p= 0.046). The risk of TB increased with low education (OR= 8.47; 95% CI= 3.01 to 23.80; p<0.001), had no BCG immunization (OR= 8.86; 95% CI= 3.28 to 23.94; p<0.001), smoking (OR 6.69; 95% CI= 2.20 to 20.38; p=0.001), high dwelling density (OR= 10.35; 95% CI= 4.06 to 26.41; p<0.001), and poor nutritional status (OR= 3.44; 95% CI= 0.85 to 14.03; p= 0.085).Conclusion: The risk of TB decreases with female sex, but increases with low education, had no BCG immunization, smoking, high dwelling density, and poor nutritional status.Keywords: Tuberculosis, sex, BCG immunization, dwelling density, nutritional statusCorrespondence: Fahmi Syahputra. Faculty of Medicine, Universitas Methodist Indonesia. Jl. Hang Tuah No.8, Madras Hulu, Medan Polonia, Kota Medan, Sumatera Utara 20151. Email: fahmisyahputra213@yahoo.comJournal of Epidemiology and Public Health (2019), 4(1): 55-59https://doi.org/10.26911/jepublichealth.2019.04.01.07
Does HBA1C Correlate with Lipid Profile in Type 2 Diabetes Mellitus? A New Evidence from Medan, North Sumatera Julianto, Endy; Silitonga, Hendrika Andriana; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 3 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diabetes mellitus (type 2 DM) is now ranked first in health problems and its prevalence tends to increase worldwide. The Diabetes Control and Complication Trial (DCCT) study showed that lowering HbA1c rates may delay or prevent chronic complications. One of the risk factors for CHD in type 2 DM is dyslipidemia, i.e lipid metabolism disorders in the form of elevated total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and decreased levels of high-density lipoprotein (HDL). This study aimed to determine the correlation between HBA1C and blood sugar, as well as the lipid profile in patients with type 2 DM.Subject and Methods: This was an analytic observational study with a cross-sectional design. The study was conducted at the Endocrinology and Metabolic polyclinic Pirngadi Hospital, Medan, North Sumatera, from January to February 2018. A total sample of 10 patients diagnosed with type 2 diabetes mellitus with obesity was selected for this study. The independent variables were blood sugar, lipid profile including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. The dependent variable was the HbA1c level. Lipid profile was measured by blood serum examination. HbA1c level was measured by blood serum examination. The data were analyzed by Pearson correlation.Results: Hba1c was positively correlated with blood sugar levels and was statistically significant (r= 0.81; p= 0.005). HbA1c correlated weakly and was statistically non-significant with total cholesterol (r= 0.14, p= 0.702), LDL (r= 0.15; p= 0.683), HDL (r= 0.04; p= 0.922), and triglycerides (r= 0.06; p= 0.860).Conclusion: HbA1c correlates with blood sugar levels but does not show a correlation with lipid profiles.Keywords: HBA1C, lipid profile, blood sugar, type 2 diabetes mellitusCorrespondence:Endy Julianto. Department of Parasitology, Faculty of Medicine, Methodist University, Medan.Indonesian Journal of Medicine (2017), 2(3): 207-212https://doi.org/10.26911/theijmed.2017.02.03.08
Determinants of Acute Respiratory Infection in Children Under Five in Simalingkar, Medan, North Sumatera Maria, Lasma; Simanjuntak, Maestro; Silangit, Thomas; Siahaan, Jekson Martiar
Journal of Epidemiology and Public Health Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Acute Respiratory Infection (ARI) is still one of the health problems in developed and developing countries including Indonesia. ARI is the most common disease in outpatients in North Sumatra, especially in Medan. This study aims to find out about the factors that influence ARI in toddlers in Sima­ling­kar Health Center Me­dan, including nutri­tional status, birth weight, history of im­muni­zation, exclusive breastfeeding, and parental smoking status.Subjects and Method: This was a cross sec­tional study. The sample used was all toddlers who came to the Simalingkar health center, amoun­ting to 100 people. Data collec­tion was carried out using interviews and ana­ly­sis was carried out using bivariate and mul­tivariate with multiple logistic regression.Results: The results showed that there was a significant influence between nutritional status, exclusive breastfeeding and parental smoking status with the incidence of ARI in infants.Conclusion: The results showed that there was a significant influence between nutritional status, exclusive breastfeeding and parental smoking status with the incidence of ARI in infants.Keywords: acute respiratory infection, child­ren under fiveCorrespondence: Lasma Maria. Faculty of Medicine, Universitas Methodist Indonesia, Medan Email: lasmamaria12­@gmail.comJournal of Epidemiology and Public Health (2020), 5(1): 26-30https://doi.org/10.26911/jepublichealth.2020.05.01.03
THE EFFECTS OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTIONATION OF SECHIUM EDULE JACQ. SWARTZ ON TRIGLYCERIDE LEVELS IN MALE RATS WITH TYPE 2 DIABETES MELLITUS Siahaan, Jekson Martiar; Julianto, Endy; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The prevalence of diabetes mellitus (DM) from year to year is increasing. Hyper­glycemia that occurs in DM is caused by oxidative stress that damages pancreatic ? cells. This situation can be controlled with synthetic hypoglycemic drugs, but it requires high medical costs. Therefore, alternative therapies that are easily available, relatively inexpensive, have potential anti-hypoglycemia and anti-cholesterolemia which is found in conjoined flasks (Sechium edule (Jacq.) Swartz) which contains flavonoids are needed. The purpose of this study was to analyze the effectiveness of ethanol extract and fractionation of ethyl acetate extracts of Sami (pumpkin) (Sechium edule (Jacq.) Swartz) as anti-hipoglycemia and anti-hypertriglycerides in white male wistar rats (Rattus novergius sp.) induced by STZ-NA-HFDD.Subjects and Method: A randomized controlled trial was conducted to assess the effectiveness of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract. The sample included white male wistar rats (Rattus novergius sp.) Hyperglycemia induced by STZ-NA-HFD. The dependent variable was triglyceride levels. The independent variables were administration of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract.Results: Ethyl acetate fraction 45 mg/kgBW better reduce triglyceride levels but statistically does not have significant differences between groups.Conclusion: The group that received Metformin and the group that was given ethanol extract 45 mg/kgBW had lower triglyceride levels compared to the other therapy and control groups.Keywords: Hipertrigliseridemia, diabetes mellitus, STZ-NA-HFDCorrespondence: Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: Jekson.siahaansked­@­gmail.comIndonesian Journal of Medicine (2019), 4(4): 371-375https://doi.org/10.26911/theijmed.2019.04.04.10 
The Effectiveness of Albendazole-Levamisole and Mebendazole-Levamisole on the Intensity of Trichuris trichiura Infection in Elementary School Children Anto, Endy Juli; Siahaan, Jekson Martiar; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Trichuris trichiura worm infec­tion is still a major public health problem in Indo­­nesia, especially in peripheral areas. Until now, the search for antihelmintic combinations that have a high healing ability against T. tri­chi­ura infections and in the search for truly effective worm­ing is still being done. Albendazole and Mebendazole single doses still show limited ef­fi­ca­cy in the treatment of T. trichuria worms. The combination of Albendazole with Levamisol can increase effectiveness, but this combination still needs further investigation. Based on that fact, it is necessary to study the effectiveness compa­rison of the degree of infection intensity between the treatment of Albendazol-Levamisol and Me­ben­dazol-Levamisol against T. trichiura.Subjects and Method: A double blind ran­domized control trial was conducted at the State Elementary School in Medan, North Sumatera, from April to October 2019. A sample of 60 children was selected for this study. The depen­dent variable was the number of eggs decreased, the cure rate, and side effects. The independent variables were Albendazole 400 mg-Levamisol 50 mg/ 100 mg and Mebendazole 500 mg-Levamisol 50 mg/100 mg. The stools of elementary school children were examined using the Kato-Katz method to find eggs of T. trichiura infection. Data analysis was performed using the Chi square test. Results: Samples in the Albendazol-Levamisol and Mebendazol-Levamisol groups were 30 children, respectively. Children infected with T. trichiura consisted of 58 children of mild in­tensity (96.7%) and 2 children of moderate inte­nsity (3.3%). On the results of stool examination, a significant difference in the number of eggs decreased in the two groups was obtained (p <0.001) and 96.7% was the cure rate for T. trichiura infection in the two groups of Alben­dazol-Levamisol and Mebendazol-Levamisol. In this study, there were no significant differences in side effects in the two treatment groups.Conclusion: Treatment of T. trichiura infection with single doses of Albendazol-Levamisol and Mebendazol-Levamisol showed that there were sig­nificant differences in the Number of D­ecreased Eggs. Meanwhile, for the cure rate, there was no difference between the Albendazol-Levamisol and Mebendazol-Levamisol groups.Keywords: T. trichiura, Albendazole-Levamisol, Mebendazole-LevamisolCorrespondence: Endy Juli Anto. Department of Parasitology, Faculty of Medicine, Universitas Methodist In­donesia, Medan, Indonesia. Email: dr.endy­julianto@gmail.com. Mobile: +62-823 6766-7575Indonesian Journal of Medicine (2020), 5(1): 17-23https://doi.org/10.26911/theijmed.2020.05.01.03
The Effects of Ethanol Extract, Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on the High-density Lipoprotein Level in Male White Mice Siahaan, Jekson Martiar; Anto, Endy Juli; Fauzi, Tengku Muhammad
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Cholesterol imbalance occurs in Diabetes Mellitus, where high-density lipo­protein (HDL) levels are low and low-density lipoprotein (LDL) increases, where this im­balance results in the appearance of athero­sclerosis. HDL has antiarterosclerotic poten­tial so it needs to be targeted for therapy. One of the bioactive compounds that have this effect is found in chayote (Sechium edule (Jacq.) Swartz). This study aimed to examine the effects of ethanol extract, Chayote (Sechium Edule (Jacq.) Swartz) fraction and juice on the hdl level in male white miceSubjects and Method: A randomized controlled trial study was conducted to test HDL level in 54 male white rats of the Wistar strain (Rattus novergius sp.) after received ethanol extract, Chayote (Sechium Edule (Jacq.) Swartz) fraction and juice. The depen­dent variable was the HDL level. The indepen­dent variable was the variation in the dose of ethanol extract, fraction and Sechium edule (Jacq.) Swartz Juice. The data were analyzed using Anova test.Results: The treatment group induced by Streptozotocin 50 mg / kgBW + nicotinamide (120 mg/kgBW) + HFD and obtained ethanol extract of chayote fruit 150 mg / kgBW, orally had the highest average HDL levels compared to other groups (Mean = 17.31; SD = 3.14).Conclusion: The ethanol solvent found in the ethanol extract is better because it attracts biaoctive compounds so that it has a better effect than the ethyl acetate fraction and the n-hexane fraction.Conclusion: The ethanol solvent found in the ethanol extract is better because it attracts biaoctive compounds so that it has a better effect than the ethyl acetate fraction and the n-hexane fraction.Keywords: HDL, Flavonoid, Sechium edule (Jacq.) SwartzCorrespondence: Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: jekson.siahaan.sked@gmail.comIndonesian Journal of Medicine (2021), 06(02): 145-151https://doi.org/10.26911/theijmed.2021.06.02.03
PENYULUHAN MELAHIRKAN GENERASI EMAS KEPADA MASYARAKAT DESA LUMBAN PEA TIMUR, KABUPATEN TOBA Jekson Martiar Siahaan; Juli Jamnasi; Juli Y. Mega; Laura Octavina Siagian; Lesmana Syahrir; Lylys Surjani; Maestro B. U. Simanjuntak; Paul S. M. L. Tobing; Suryati Sinurat; Tengku M. Fauzi; Eka Samuel P. Hutasoit; Jan Pieter Sihombing; Hadyanto Lim; Hendrika A. Silitonga; Ronald T. H. Tambunan; Menang Bastanta Tarigan; Salomo G. U. Simanjuntak; Sumihar M. R. Pasaribu; Putri C. Eyanoer; Dina Riani Purba; Yohanna Agustina Sinaga
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 2 No 1 (2022): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (906.228 KB) | DOI: 10.46880/methabdi.Vol2No1.pp70-73

Abstract

Community Service (PkM) is carried out by the Faculty of Medicine Universitas Methodist Indonesia by providing counselling how to prepare the Gold Generation. PkM was held on 8-11 June 2022 at Lumban Pea Timur, Balige,Toba District, North Sumatera. The method used is to provide counselling/lectures and provide motivation, then followed by question and answer to obtain results and solutions as a form of solving problems and obstacles faced. The results of PkM with counselling are very effective considering that there are still many people who do not get information about the meaning of Gold Generation. With this counselling, the public becomes aware of the Gold Generation. Thus, it is hoped that the people of Lumban Pea Timur will aware and know how to prepare the Gold Generation for their community
TUMOR SUPRESOR GEN p53 SEBAGAI TARGET PENGOBATAN “CANCER” Jekson Martiar Siahaan; Tengku Muhammad Fauzi
Majalah Ilmiah METHODA Vol. 11 No. 1 (2021): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

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Abstract

The p53 protein functions as a biological molecule that breaks the cycle of damage to DNA damage, even the important function of this molecule is to check whether the organ cells are complete or damaged. However, p53 can undergo mutations that will instead be an oncogene. One way to deal with this is gene therapy, namely PRIMA-1 (p53 Reactivation and Induction of Massive Apoptosis). Until now, further studies are still needed on the effectiveness of this therapy
Co-Authors Agnes Imelda Manurung Ainun, Nur Azizah Ardinata, Dedi - Ariani, Peny Ariescha, Putri Ayu Yessy Atmawidjaja, Rachmat Bahar, Dinillah Salsabila Br. T. Tambun, Gita Sradha Budi Darmanta Sembiring Butar-Butar, Harry Chalil, M. Jalaluddin A. Daulay, Agus Husein Dina Riani Purba Dona Pasaribu Dwi Lunarta Doderina Siahaan Efbertias Sitorus Eka Samuel P. Hutasoit Endy Juli Anto Endy Juli Anto endyjulianto Fadinie, Wulan FAHDI, FIRDAUS Fauzi, Tengku M. Fauzi, Tengku Muhammad Hadyanto Lim Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Hendrika A. Silitonga Hendrika Silitonga Hutagalung, Mangatas Halomoan Parluhutan Hutagalung, Sanggam B. Hutagalung, Sanggam Bangun Hutapea, Kenal P. Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Imelda Montes Monika Simanungkalit Irfan Hamdani, Irfan Irina, Sinta Jadeny Sinatra Jan Pieter Sihombing Jones Simatupang Juli Jamnasi Juli Jamnasi Juli Y. Mega kenvin rusli Laura Octavina Siagian Lesmana Syahrir Lesmana Syahrir, Lesmana Lubis, Andriamuri P. Maestro B. U. Simanjuntak Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Maria, Lasma Menang Bastanta Tarigan Momot, Estela Salomina Nababan, Manaor Bismar Posman Nababan, Titus Imanuel Nainggolan, Ranatha NH Nainggolan, Serevina Napitupulu, Helen Debora Natalie S., Karen Nazma, Diani Nurmala Sari Pakpahan, Edwin Anto Panataria, Lince Romauli Panjaitan, Bintang Andika Panjaitan, Goklas Parhusip, Rudolf S. Pasaribu, Sumihar M. R. Pasaribu, Sumihar Maurist Rantos Pasaribu, Sumihar MR Paul Saut Marganda L Tobing Perangin-angin, Guntur Pratiwi, Ade Dwi Purba, Amril Putri C. Eyanoer Putri Chairani Eyanoer Putri Chairani Eyanoer, Putri Chairani Ria Oktavia Ricke Loesnihari Rimbun, Surjadi Ronald T. H. Tambunan Sagala, Daniela Salamon, Yuda Monang Salomo G. U. Simanjuntak Salomo Garda Utama Simanjuntak Sanggam B Hutagalung Sanggam B. Hutagalung SARAGIH, MEYLIN KRISTINA Sari, Nur Mala Sembiring, Bob Agustinus Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Dwi Lunarta D. S. Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Amordekhai Imvan Parlindungan Sihombing, Parsaoran Sihotang, Ruth Wydia Wati Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Silitonga, Hendrika Andriani Simangunsong, Batara Simanjuntak, Jeremia Simanjuntak, Maestro Simanjuntak, Maestro Bina Utama Simanjuntak, Pantas Simanjuntak, Salomo Garda Utama Simanjuntak, Salomo Garda Utama Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinatra, Jadeny Sinurat, Suryati Sirait, Kilian Sitepu, John Frans Siti Normi, Siti Sitompul, Michael Sabatino Sitorus, Ragnar Oktavianus Stephanie S., Kezia Surjani, Lylys Suryati Sinurat Syahputra, Fahmi Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Ruth Septianna Br. Tanjung, Qodri F. Tarigan, Juliyanti Tarigan, Leonardo Tarigan, Menang Bastanta Tengku M. Fauzi Tengku Muhammad Fauzi Tiji, Widjaya Taufik Tobing, Paul S. M. L. Urip Harahap Vivian Vivian Wijaya, Mega Yohanna Agustina Sinaga YUNAFRI, ANDRI Zainumi, Cut M.