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All Journal Majalah Obstetri dan Ginekologi Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Saputra, Gede Ardi
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Health Professions Medicine & Pharmacology

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Lung Adenocarcinoma Complicated By Hydropneumothorax And Pericardial Effusion With Impending Cardiac Tamponade: A Rare Case Report From A Rural Hospital In Ketapang Regency: english Saputra, Gede Ardi; Kalua, Kesih; Willim, Herick Alvenus; Munthe, Eva Lydia
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.9259

Abstract

Lung adenocarcinoma is often associated with pulmonary complications such as hydropneumothorax and pleural effusion, and cardiac complications such as cardiac tamponade and pericardial effusion, but are very rare. In our case, a 52-year-old woman presented with worsening shortness of breath for 1 month. The patient underwent thoracentesis after chest X-ray showed right pleural effusion. Pleural fluid cytology showed pulmonary adenocarcinoma. Chest CT scan showed hydropneumothorax and pericardial effusion. In conclusion, pleural effusion is common in lung malignancies. In this case, hydropneumothorax occurred due to repeated thoracentesis of massive pleural effusion. Pericardial effusion is uncommon. This is due to the presence of metastases in the pericardium that obstruct lymphatic drainage, so pericardial fluid analysis is needed.
Efficacy and Safety of Pravastatin in Placental-Related Disorders: Systematic Review And Meta-Analysis Of Randomized Controlled Trials: english Saputra, Gede Ardi; Pandiangan, Asri; Suryatman, Muhammad Villiandy; Swastini, Ni Putu
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 19 No 1 (2025): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

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Abstract

Placental-related disorders impact over 33% of pregnancies. Several of these syndromes lead to higher rates of maternal and fetal death and morbidity and can have long-term health consequences. Several RCTs have found that pravastatin is associated with a significant reduction in the incidence of preterm preeclampsia and preterm birth. However, alternatives require substantial evidence. On the methods, two writers assessed the risk of bias. The Cochran test was used to assess heterogeneity among studies. The Mantel-Haenszel technique was used to obtain the results. The study's results were described using forest plots. The study used six randomized controlled trials. Findings showed a reduced risk of preeclampsia, preterm birth, and NICU admission in pregnant women taking pravastatin. There was no significant reduction in the risk of neonatal respiratory distress, congenital disorders, and adverse events of headache, heartburn, and musculoskeletal pain. Our conclusion, this study suggests that pravastatin use may have beneficial effects in reducing the risk of placental-related disorders in patients.
Emerging role of Transvaginal Ovarian Needle Drilling in CC-resistant PCOS: A meta-analytical comparison with LOD Huzna, Nanda Cynthia; Maulana, Rifqi Fadhil; Deswindra, Mohamad Reihansyah; Saputra, Gede Ardi; Megawati, Melia; Pratama, Muhammad Reqza
Majalah Obstetri & Ginekologi Vol. 34 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V34I12026.42-52

Abstract

HIGHLIGHTS This meta-analysis compares the effectiveness of transvaginal ovarian needle drilling (TND) versus laparoscopic ovarian drilling (LOD) in clomiphene citrate-resistant PCOS patients, focusing on pregnancy outcomes and ovarian reserve indicators. The findings indicate comparable pregnancy rates between TND and LOD, while TND may offer the advantage of better ovarian reserve preservation and a minimally invasive approach suitable for outpatient settings.   ABSTRACT Objective: Clomiphene citrate-resistant polycystic ovary syndrome (CC-resistant PCOS) remains a therapeutic challenge, often requiring second-line surgical interventions to induce ovulation. Laparoscopic ovarian drilling (LOD) is the standard approach, whereas transvaginal ovarian needle drilling (TND) has emerged as a minimally invasive alternative with potential advantages in preserving ovarian reserve. This study compared the effectiveness and safety of TND versus LOD by evaluating pregnancy rates and postoperative anti-Müllerian hormone (AMH) levels. Materials and Methods: A systematic review and meta-analysis was conducted following PRISMA guidelines. Literature searches were performed in PubMed, Cochrane Library, and ScienceDirect up to June 2025. Studies involving women with CC-resistant PCOS comparing TND and LOD were included. Primary outcomes were pregnancy rates and postoperative AMH levels. Risk of bias was assessed using Cochrane RoB-2 and ROBINS-I tools. Pooled estimates were calculated using a random-effects model. Results: Four studies involving 660 participants were included. The pooled relative risk for pregnancy in the TND group compared to the LOD group was 0.74 (95% CI: 0.39–1.41; p = 0.36; I² = 71%), indicating no statistically significant difference. The mean difference in postoperative AMH levels favored TND (+1.12 ng/mL; 95% CI: -0.06–2.3; p = 0.06; I² = 90%), suggesting a trend toward better ovarian reserve preservation. TND demonstrated comparable pregnancy outcomes with a potential advantage in minimizing ovarian damage. Conclusion: TND may offer similar pregnancy outcomes with better ovarian reserve preservation than LOD; however, further high-quality studies are required to confirm these findings.
Co-Authors Deswindra, Mohamad Reihansyah Huzna, Nanda Cynthia Kalua, Kesih Maulana, Rifqi Fadhil Melia Megawati, Melia Munthe, Eva Lydia Pandiangan, Asri Pratama, Muhammad Reqza Suryatman, Muhammad Villiandy Swastini, Ni Putu Willim, Herick Alvenus