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All Journal Jurnal Kesehatan Andalas YARSI Medical Journal
Fiatiningsih, Istiana
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Health Professions Medicine & Pharmacology

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OTOVAKSIN SEBAGAI TERAPI ALTERNATIF INFEKSI MYCOBACTERIUM TUBERCULOSIS PADA TIKUS PUTIH (RATTUS NORVEGICUS) Praseno, Praseno; Nurrokhman, Nurrokhman; Fiatiningsih, Istiana
Jurnal Kedokteran YARSI Vol 15, No 3 (2007): SEPTEMBER-DESEMBER 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v15i3.1077

Abstract

Tuberculosis (TB) is still an important public health problem, especially in developing countries such as Indonesia. Efforts have been made to overcome the problem, however, number of cases is still high. This is due to various factors which might affect the development of the disease. Increasing number of resistant strains against antimycobacterial drugs is one of the major factors. Therefore, alternative method to control TB is needed.The aim of this study was to evaluate the effectiveness of autogenous vaccine on healing process of infection caused by Mycobacterium tuberculosis in rats. Eighteen Wistar rats (Rattus norvegicus) were infected with 109 colony forming unit of M. tuberculosis subcutaneously. One week after infection, the rats were divided randomly into 2 groups, first group were treated with autogenous vaccine and the other were left untreated (control group). Autogenous vaccine was given subcutaneously with the dose of 108 cfu/0,1 ml every 7 days 3 times. Subcutaneous nodules were evaluated every 3 days and weight gain was evaluated 3 times. Laboratory examinations were done, including acid fast bacilli stain, histopatological feature and serologic test. The result showed that recovery of subcutaneous nodules in autovaccine treated group of rats was faster than that of untreated control group. Acid fast bacilli staining showed that the number of micobacteria found in the lung, liver, spleen and kidney of autovaccine treated group were much lower than those found in the control group. Histopathology features showed that lymphocytes infiltration in the lung and other organs was heavier in the control group than that of treated group. In conclusion, animal study on rats showed that autogenous vaccine had effective therapeutic effect on healing process for M. tuberculosis infection.   
Eumisetoma pada Toraks dan Abdomen: Suatu Kasus Jarang Fran, Jimy; Fiatiningsih, Istiana; Romus, Ilhami
Jurnal Kesehatan Andalas Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1803

Abstract

Mycetoma is a chronic granulomatous infectious disease of the skin, subcutis, fascia and bones caused by bacteria (actinomycetoma) or fungi (eumycetoma) in adults aged 20-40 years old, male to female ratio is 3,7:1 respectively. The clinical finding is a painless, solid and cold subcutaneous node. It has been reported a 43-year-old woman with a painless suppurative lump in her chest, stomach, armpits and legs in the past year. The lump were hypertrophic scars, atrophic scars, nodules and erythematous papules with pustules and sinuses, which excretes exudate greenish-yellow. The patient had a history of working in an oil palm farm. Histopathological examination of hematoxylin-eosin showed suppurative granulomatous inflammation consisting of epitheloid histiocytes, solid lymphocytes and neutrophils, and datia cells. PAS (Periodic acid-Schiff) staining showed positive results. The diagnosis of deep mycosis eumycetoma was confirmed based on physical examination and histopathological examination. Eumycetoma is a rare deep fungal disease. Supporting investigations such as direct microscopy, histopathology with biopsy, and culture are needed to establish the diagnosis. The therapies are antifungal drugs and surgery. Death is possible if the infection occurs in the chest or head cavity.Keywords: deep mycosis, eumycetoma, granules, mycetoma, sinuses
Co-Authors Fran, Jimy Ilhami Romus, Ilhami Nurrokhman, Nurrokhman Praseno Praseno