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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Jurnal Kesehatan Andalas Jurnal Pengabdian Kesehatan Biomedika
Ilhami Romus, Ilhami
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Profil Klinikopatologik Biopsi Massa Kolorektal di Instalasi Patologi Anatomi RSUD Arifin Achmad Provinsi Riau Periode Januari 2015 - Desember 2019 Romus, Ilhami; Nisa, Khairun
Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v15i1.2021.32-40

Abstract

Colorectal masses can be non-neoplasm, benign neoplasm and malignant neoplasm. Diagnosis of colorectal mass can be done by biopsy or surgery then followed by histopathological examination. The aim of this study was to described the histopathology feature of colorectal mass biopsy in the Anatomic Pathology Laboratory of Arifin Achmad Regional Hospital in Riau Province January 2015 - December 2019. This study found 304 cases consisted of men (55,6%) and women (44,4%). The highest number of cases was in the 50-59 years age group (29,3%). The Malays (17,8%) was the largest ethnic group. The highest occupation was housewives (22%). Rectal tumor (73,1%) was the most common clinical diagnosis. The histopathological examination results of colorectal mass biopsy were non-neoplasm (26,7%), benign neoplasm (1,3%), and malignant neoplasm (72%). Adenocarcinoma was the most common biopsy histopathologic feature of malignant neoplasm (64,8%).
Effect of Bortezomib on Total Cholesterol, Triglycerides and Histopathology Abdominal Aorta in Rats of Atherosclerosis Model Ismawati, Ismawati; Romus, Ilhami; Maryanti, Esy; Permatasari, Nopi; Luthfianty, Elfiah
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.5

Abstract

The effects of using proteasome inhibitors on atherosclerosis could be beneficial or detrimental. This study aimed to analyze the effects of proteasome inhibitors in the progression stage. Experimental animals (18 rats) were divided into three groups, namely control (C) as a group of rats given standard feed, P1 as atherosclerosis-induced rat group, and P2 as atherosclerosis-induced rat group and given proteasome inhibitors. Proteasome inhibitor administered was bortezomib at a dose of 50µg/kgBW/day intraperitoneally on day 1 and 3. After four days of treatment, the termination and measurement of serum total cholesterol, serum triglycerides, and abdominal aorta histopathology with hematoxylin-eosin staining were carried out. Serum total cholesterol levels were measured using the CHOD-PAP (Cholesterol Oxidase-Peroxidase Aminoantypirin) method, whereas serum triglyceride levels were measured using the GPO-PAP (glycerol phosphatase oxidase−phenol4-amino antipyrene peroxidase) method. Histopathological assessment was carried out with a scoring system in 9 fields of view with a 400x magnification, which was then averaged. The ANOVA test showed significant differences in serum total cholesterol, serum triglycerides, and abdominal aortic histopathology between atherosclerosis and control groups, but there were no significant differences in the administration of bortezomib in atherosclerosis except in serum triglyceride levels. It can be concluded that the administration of 50µg/kg bortezomib for four days in the rats model of the progression stage of atherosclerosis can decrease serum triglyceride levels, although it can not inhibit the formation of atherosclerotic lesions and has no effect on serum total cholesterol. 
EFEK EKSTRAK INULIN UMBI DAHLIA TERHADAP PERLEMAKAN HATI PADA TIKUS DIABETES MELITUS TIPE 2 Ismawati, Ismawati; Aufa, Athiatul; saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
E-Jurnal Medika Udayana Vol 13 No 9 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i09.P13

Abstract

Several studies show a correlation between intestinal microbiota disturbances and metabolic disorders, including type 2 diabetes mellitus (T2DM). Fatty liver is one of the complications that occurs due to T2DM. Fatty liver is characterized by the accumulation of lipids in the liver in response to increased triglyceride synthesis in hepatocytes and is thought to be associated with disturbances in the gut microbiota so that changes in the gut microbiota can be a potential target for T2DM treatment. It is known that inulin, a prebiotic, can improve intestinal microbiota disorders. This study aims to analyze the effect of administering inulin from dahlia tubers on fatty liver in T2DM rats.The research design is an experimental study with a post-test-only control group design conducted from June to November 2023. The study used twenty male Rattus norvegicus Wistar strain divided into five groups: a control group, a T2DM-induced group, T2DM groups given inulin extract at doses of 0.5 mg/gBW, 1.0 mg/gBW, and 1.5 mg/gBW. The results showed that the T2DM group had a higher significant percentage of fatty liver (p <0.01) than the control group. Compared to the T2DM group, there was a decrease in the percentage of fatty liver in the T2DM groups given inulin at all doses (p<0.05). This study concluded that inulin administration can reduce fatty liver in T2DM rats. Keywords : Dahlia tubers., fatty liver., inulin., type 2 diabetes mellitus
Deteksi Hiperkolesterolemia dan Edukasi Efeknya Terhadap Kesehatan Pada Masyarakat Kelurahan Bangkinang Kabupaten Kampar ismawati, ismawati; Romus, Ilhami
Jurnal Pengabdian Kesehatan Vol 6, No 2 (2023): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v6i2.163

Abstract

Penyakit Jantung Koroner  (PJK) masih merupakan masalah kesehatan karena  dapat mendatangkan beban morbiditas, mortalitas dan  beban sosial ekonomi bagi penderita, keluarga, masyarakat, dan negara. Mengingat aterosklerosis sebagai patogenesis PJK memerlukan waktu yang panjang untuk menimbullkan gejala maka deteksi dini melalui skrining kesehatan penting dilakukan. Pemeriksaan kolesterol darah merupakan salah satu screening kesehatan terkait PJK yang sangat penting. Upaya skrining hiperkolesterolemia membutuhkan peran serta berbagai pihak, baik pemerintah, swasta maupun masyarakat. Hal ini perlu untuk mengendalikan hiperkolesterolemia sehingga insiden PJK dapat ditekan.  Kegiatan pengabdian ini bertujuan untuk mendeteksi hiperkolesterolemia pada masyarakat secara dini dan memberikan edukasi terkait efek hiperkolesterolemia terhadap kesehatan seperti penyakit jantung koroner. Melalui kegiatan ini, diharapkan dapat menurunkan insiden PJK sehingga meningkatkan kualitas hidup masyarakat kelurahan Bangkinang, Kampar dan masyarakat Indonesia pada umumnya. Kegiatan pengabdian ini dilakukan oleh Tim Pengabdian Masyarakat Fakultas Kedokteran Universitas Riau pada bulan Oktober 2021 dengan mematuhi protokol kesehatan. Sasaran pengabdian ini adalah masyarakat Kelurahan Bangkinang, Kecamatan Bangkinang Kota, Kabupaten Kampar yang berjumlah 96 orang. Kegiatan dilakukan dengan cara mengukur kadar kolesterol dilanjutkan dengan edukasi mengenai efek hiperkolesterolemia terhadap kesehatan. Pemeriksaan kolesterol dilaksanakan dengan menggunakan alat test digital. Pemberian edukasi mengenai efek hiperkolesterolemia terhadap kesehatan dilakukan melalui konsultasi dengan pakar disertai dengan pemberian flyer  edukasi efek hiperkolesterolemia terhadap kesehatan. Sebagian besar peserta pada kegiatan pengabdian ini memiliki kadar kolesterol yang melebihi nilai normal (hiperkolesterolemia) (77,1 %), hanya 22,9 % yang memiliki kadar kolesterol dalam rentang normal. Terdapat perbedaan yang bermakna hiperkolesterolemia berdasarkan jenis kelamin tetapi tidak terdapat perbedaan yang bermakna hiperkolesterolemia berdasarkan umur. Pemberian edukasi mengenai dampak hiperkolesterolemia terhadap kesehatan sangat penting disampaikan kepada masyarakat agar dapat dilakukan pencegahan terhadap penyakit jantung koroner.
Eumisetoma pada Toraks dan Abdomen: Suatu Kasus Jarang Fran, Jimy; Fiatiningsih, Istiana; Romus, Ilhami
Andalas Journal of Health Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1803

Abstract

Mycetoma is a chronic granulomatous infectious disease of the skin, subcutis, fascia and bones caused by bacteria (actinomycetoma) or fungi (eumycetoma) in adults aged 20-40 years old, male to female ratio is 3,7:1 respectively. The clinical finding is a painless, solid and cold subcutaneous node. It has been reported a 43-year-old woman with a painless suppurative lump in her chest, stomach, armpits and legs in the past year. The lump were hypertrophic scars, atrophic scars, nodules and erythematous papules with pustules and sinuses, which excretes exudate greenish-yellow. The patient had a history of working in an oil palm farm. Histopathological examination of hematoxylin-eosin showed suppurative granulomatous inflammation consisting of epitheloid histiocytes, solid lymphocytes and neutrophils, and datia cells. PAS (Periodic acid-Schiff) staining showed positive results. The diagnosis of deep mycosis eumycetoma was confirmed based on physical examination and histopathological examination. Eumycetoma is a rare deep fungal disease. Supporting investigations such as direct microscopy, histopathology with biopsy, and culture are needed to establish the diagnosis. The therapies are antifungal drugs and surgery. Death is possible if the infection occurs in the chest or head cavity.Keywords: deep mycosis, eumycetoma, granules, mycetoma, sinuses
EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Hopi, Zikrilla mayuli; Ismawati, Ismawati; Saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
Co-Authors A.A. Ketut Agung Cahyawan W Aufa, Athiatul Dyna, Fitri Esy Maryanti Fiatiningsih, Istiana Fran, Jimy Hopi, Zikrilla mayuli Ismawati ismawati Ismawati Ismawati Luthfianty, Elfiah Mukhyarjon Paramitha, Sonia Dinda Permatasari, Nopi Saryono Saryono Sri Yanti Veni Dayu Putri