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All Journal Majalah Patologi Indonesia Jurnal Kesehatan dan Kedokteran
Siregar, Ren Astrid Allail
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Health Professions Public Health

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Hubungan Ekspresi CD117 dan Epidermal Growth Factor Receptor (EGFR) terhadap Grading Histopatologi Adenoid Cystic Carcinoma pada Kelenjar Liur Siregar, Ren Astrid Allail; Alferraly, T. Ibnu; Delyuzar
Majalah Patologi Indonesia Vol. 29 No. 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.402

Abstract

BackgroundTend to have adenoid cystic carcinoma (AdCC) is one of malignant epithelial tumor of the salivary gland poor prognosis, localrecurrence and metastases. Histopathological grading system according Weert, et al. observed from presence or absence solidcomponent of AdCC. CD117 is a transmembrane tyrosine kinase receptor usually strong expression in AdCC. EGFR belongs to theErbB family of receptor tyrosine kinases associated with cell proliferation, angiogenesis and metastases. Patients with advanceddisease may benefit from targeted therapy besides conventional management. Expression of CD117 and EGFR may give proposaltherapy through difference histology pattern of AdCC based on histopathological grading.MethodsThis is an analytical descriptive study with cross sectional approach. Formalin-fixed paraffin-embedded sections from 35 adenoidcystic carcinomas were obtained for histopathological grading and for immunostained of CD117 and EGFR using monoclonalantibodies. The staining intensity and percentage of cells with membranous and cytoplasmic of CD117 and EGFR expression werescored and then grouped according to the parameters of the Allred scoring system.ResultsChi-square test between CD117, EGFR expression and histopathological grading of AdCC showed no sigficant differences.Besides, McNemar test between CD117 and EGFR expression and histopathological grading AdCC showed significant differences,p-value=0.03 (p<0.05).ConclusionsCD117 and EGFR could be used to detected salivary gland AdCC
Relationship Between Waist Circumference and Body Mass Index with HbA1c Levels in Patients with Type 2 Diabetes Mellitus Febriani, Sukma; Rambe, Ismatul Fauziah; Rahman, Shahrul; Siregar, Ren Astrid Allail
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 2 (2026): Juni: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i2.2657

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and complex pathophysiological mechanisms. Obesity, assessed through Body Mass Index (BMI) and waist circumference (WC), is commonly associated with poor glycemic control, yet previous studies have reported inconsistent findings. Objective: This study aimed to analyze the relationship between waist circumference and BMI with HbA1c levels in patients with T2DM at Haji General Hospital Medan. Methods: A quantitative analytical study with a cross-sectional design was conducted involving 48 patients with T2DM who met the inclusion criteria. Anthropometric data, including BMI and WC, were measured directly, while HbA1c values were obtained from medical records. Bivariate analysis was performed using the Spearman correlation test, and multivariate analysis was conducted using ordinal logistic regression. Results: The analysis showed no significant association between waist circumference and HbA1c levels (r = −0.141; p = 0.339) or between BMI and HbA1c levels (r = 0.075; p = 0.611). Multivariate analysis also indicated that BMI and WC simultaneously did not significantly affect HbA1c categories (p > 0.05). Implications: These findings suggest that glycemic control in T2DM patients is influenced by multifactorial mechanisms beyond anthropometric parameters, highlighting the importance of considering behavioral, clinical, and therapeutic factors in diabetes management. Originality: This study provides context-specific evidence by simultaneously evaluating BMI and WC in a clinical outpatient population, contributing to the ongoing debate regarding the relevance of simple anthropometric indicators in predicting glycemic control.
Co-Authors Alferraly, T. Ibnu Delyuzar, Delyuzar Febriani, Sukma Rambe, Ismatul Fauziah Shahrul Rahman, Shahrul